Controlling the adhesome to regulate cell fate on biomaterials. Mesenchymal stem cell-based tissue engineering practices are hampered worldwide by the lack of appreciation and understanding of the matrix-mediated cues that must be provided during adhesion and spreading to drive cells to definitive tissue end points. This project will address these knowledge deficiencies by combining high throughput array technologies, a set of tailorable self-assembling biomaterials and real-time biosensors to r ....Controlling the adhesome to regulate cell fate on biomaterials. Mesenchymal stem cell-based tissue engineering practices are hampered worldwide by the lack of appreciation and understanding of the matrix-mediated cues that must be provided during adhesion and spreading to drive cells to definitive tissue end points. This project will address these knowledge deficiencies by combining high throughput array technologies, a set of tailorable self-assembling biomaterials and real-time biosensors to rapidly, at high resolution, elucidate how mechanotransductive cues determine the fate choice of mesenchymal stem cells, and furthermore, how to manipulate them with smart biomaterial design to achieve desired outcomes for tissue engineering. Read moreRead less
Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family protei ....Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family proteins as specific effectors. This project will address a new paradigm in genetics that is likely to underpin development.Read moreRead less
Developing the basis for an quality control platform for human pluripotent stem cells and their differentiated derivatives. Biophotonic techniques based on spectroscopy have the potential to provide low-cost, automatable measurements for the quality control of stem and differentiated cells produced for use in industry and regenerative medicine. This project is aimed at acquiring the fundamental scientific knowledge base required to bring this about.
Non-differentiable Energy Minimisation For Modelling Fractured Porous Media. This project is aimed at advancing theoretical, computational and experimental bases for the fracturing of geomaterials, and providing scientists and engineers with much needed predictive tools for quantitative assessment of the responses. By incorporating previously neglected aspects such as energy minimisation, advanced constitutive modelling, and non-planar interacting fracture growth, confidence in the design and pl ....Non-differentiable Energy Minimisation For Modelling Fractured Porous Media. This project is aimed at advancing theoretical, computational and experimental bases for the fracturing of geomaterials, and providing scientists and engineers with much needed predictive tools for quantitative assessment of the responses. By incorporating previously neglected aspects such as energy minimisation, advanced constitutive modelling, and non-planar interacting fracture growth, confidence in the design and planning of engineering processes in fractured porous media will be increased to the point that costly over/under designs are avoided. Through the use of the tools developed, it will be possible to detect weaknesses in the design, assess the impact and implement effective measures to improve performance.Read moreRead less
Robustness-oriented and serviceable design of innovative modular buildings. This project aims to unlock the full potential of prefabricated modular buildings through innovative framing solutions in combination with new evaluation methods to enhance serviceability and improve safety under extreme events. Advanced 3D hybrid testing and analysis will be used to create new knowledge on the complex system-level dynamic behaviour of modular buildings. The expected outcome of this project will lead to ....Robustness-oriented and serviceable design of innovative modular buildings. This project aims to unlock the full potential of prefabricated modular buildings through innovative framing solutions in combination with new evaluation methods to enhance serviceability and improve safety under extreme events. Advanced 3D hybrid testing and analysis will be used to create new knowledge on the complex system-level dynamic behaviour of modular buildings. The expected outcome of this project will lead to safe, affordable, and environmentally sustainabe modular building construction. The project will provide significant benefits to designers, manufacturers and regulators to improve the resilience of the building stock and to support greater design and manufacturing innovations.Read moreRead less
Fundamental theoretical and experimental investigation of cartilage mechanics. Arthritis and chronic joint symptoms are one of the leading causes of disability in the community, yet a fundamental understanding of joint mechanics has yet to be realised. The aim of this project is to develop a new state-of-the-art mathematical model describing cartilage behaviour in humans. The model will explain how activities like walking maintain healthy cartilage by transferring growth factors through the tiss ....Fundamental theoretical and experimental investigation of cartilage mechanics. Arthritis and chronic joint symptoms are one of the leading causes of disability in the community, yet a fundamental understanding of joint mechanics has yet to be realised. The aim of this project is to develop a new state-of-the-art mathematical model describing cartilage behaviour in humans. The model will explain how activities like walking maintain healthy cartilage by transferring growth factors through the tissue, and quantitatively explain how wear is minimised in cartilage through weeping lubrication. This model will progress our understanding of cartilage mechanics in health and disease, and so help Australians age well and productively.Read moreRead less
Microstructure-Based Computational Homogenization of Geomaterials. This project seeks to establish a basis for virtual testing of materials. This type of non-destructive testing has numerous applications of obvious benefit to society and will contribute to the continued growth and development of a large number of industries in Australia and worldwide. The methods developed will allow for cheaper, faster, and more accurate testing of materials. The outcomes of the project can find direct applicat ....Microstructure-Based Computational Homogenization of Geomaterials. This project seeks to establish a basis for virtual testing of materials. This type of non-destructive testing has numerous applications of obvious benefit to society and will contribute to the continued growth and development of a large number of industries in Australia and worldwide. The methods developed will allow for cheaper, faster, and more accurate testing of materials. The outcomes of the project can find direct application in civil engineering as well as in environmental, mining and petroleum engineering which together make up a significant portion of the nation's industry.Read moreRead less
Assessing Water Supply Security in a Nonstationary Environment. About 25% of the global population currently has inadequate access to safe and secure water. This number is expected to rise to 50% by 2050 due to increased populations and reduced river flows. While a visible water crisis (such as the one in Cape Town in 2018) can culminate in the funding of new water supply infrastructure, a planned push for infrastructure augmentation often stalls due to contradictory projections of how much wate ....Assessing Water Supply Security in a Nonstationary Environment. About 25% of the global population currently has inadequate access to safe and secure water. This number is expected to rise to 50% by 2050 due to increased populations and reduced river flows. While a visible water crisis (such as the one in Cape Town in 2018) can culminate in the funding of new water supply infrastructure, a planned push for infrastructure augmentation often stalls due to contradictory projections of how much water will be available in the future. To address this, a novel alternative for assessing water security is proposed. Our approach assesses change using historical information on river flow and water demand, adapting these to form projections that exhibit greater reliability than currently existing alternatives.Read moreRead less
High Performance Twist Drill Design and Drilling Operations for Machining Mould Steel. In this project a high performance drill point design, based on low drilling forces and high drill-life criteria when machining mould steel will be developed together with a computer application software for drilling force predictions, based on the ¡®unified-generalised mechanics of cutting approach¡¯, and optimal drilling feed and speed selection for minimum cost and time per hole, based on a multi-constraint ....High Performance Twist Drill Design and Drilling Operations for Machining Mould Steel. In this project a high performance drill point design, based on low drilling forces and high drill-life criteria when machining mould steel will be developed together with a computer application software for drilling force predictions, based on the ¡®unified-generalised mechanics of cutting approach¡¯, and optimal drilling feed and speed selection for minimum cost and time per hole, based on a multi-constraint drilling optimization analysis. Particular attention will be given to the manufacture of the drill point geometry. It is anticipated that the application software will enable the drill design, manufacture, performance and drilling conditions to be integrated.Read moreRead less
Thin-walled Structures Subjected to Impact and Blast Loading. Terrorist attacks have cost Australians much human grief and billions of dollars. Containing the consequences of a blast or impact is crucial to survival and restricting damage to critical civilian/defence infrastructure. Thin-walled structures are used extensively in such infrastructure. There is a lack of knowledge about their behaviour when subjected to impulse and blast loads. The investigators will establish the most economical m ....Thin-walled Structures Subjected to Impact and Blast Loading. Terrorist attacks have cost Australians much human grief and billions of dollars. Containing the consequences of a blast or impact is crucial to survival and restricting damage to critical civilian/defence infrastructure. Thin-walled structures are used extensively in such infrastructure. There is a lack of knowledge about their behaviour when subjected to impulse and blast loads. The investigators will establish the most economical means of designing passive blast protection into thin-walled structures and hence, Australia's critical infrastructure. This knowledge will be transferred into design standards and Australia's limited defence resources.Read moreRead less