Controlling the adhesome to regulate cell fate on biomaterials. Mesenchymal stem cell-based tissue engineering practices are hampered worldwide by the lack of appreciation and understanding of the matrix-mediated cues that must be provided during adhesion and spreading to drive cells to definitive tissue end points. This project will address these knowledge deficiencies by combining high throughput array technologies, a set of tailorable self-assembling biomaterials and real-time biosensors to r ....Controlling the adhesome to regulate cell fate on biomaterials. Mesenchymal stem cell-based tissue engineering practices are hampered worldwide by the lack of appreciation and understanding of the matrix-mediated cues that must be provided during adhesion and spreading to drive cells to definitive tissue end points. This project will address these knowledge deficiencies by combining high throughput array technologies, a set of tailorable self-assembling biomaterials and real-time biosensors to rapidly, at high resolution, elucidate how mechanotransductive cues determine the fate choice of mesenchymal stem cells, and furthermore, how to manipulate them with smart biomaterial design to achieve desired outcomes for tissue engineering. Read moreRead less
Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family protei ....Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family proteins as specific effectors. This project will address a new paradigm in genetics that is likely to underpin development.Read moreRead less
Developing the basis for an quality control platform for human pluripotent stem cells and their differentiated derivatives. Biophotonic techniques based on spectroscopy have the potential to provide low-cost, automatable measurements for the quality control of stem and differentiated cells produced for use in industry and regenerative medicine. This project is aimed at acquiring the fundamental scientific knowledge base required to bring this about.
The effect of tunelling on existing rock bolts. As more underground facilities such as rail, road, sewerage and service tunnels are constructed in our major cities, more and more frequently new tunnels have to cross over or run alongside existing tunnels. As the roofs of tunnels are generally supported by rock bolts and lined with shotcrete, the support system can be damaged by the rock movements caused by the excavation of the new tunnel. Little research has been carried out on this problem, an ....The effect of tunelling on existing rock bolts. As more underground facilities such as rail, road, sewerage and service tunnels are constructed in our major cities, more and more frequently new tunnels have to cross over or run alongside existing tunnels. As the roofs of tunnels are generally supported by rock bolts and lined with shotcrete, the support system can be damaged by the rock movements caused by the excavation of the new tunnel. Little research has been carried out on this problem, and so often expensive deviations have to be made to tunnels to avoid going near existing ones. The proposed research will provide numerical tools to allow prediction of loads induced into rock bolts by nearby tunnels, leading to more economical and safer tunnel design.
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Time-dependent dynamic, creep and shrinkage response of curved structural members. This project concerns curved structural members, such as bridge beams, that are subjected to dynamic excitation and to concrete shrinkage and creep. Hitherto, unified formulations for the structural behaviour of these members have not been properly developed. The proposal seeks to build on a previous ARC DP of the investigator that produces significant results for static loading, by developing a sophisticated meth ....Time-dependent dynamic, creep and shrinkage response of curved structural members. This project concerns curved structural members, such as bridge beams, that are subjected to dynamic excitation and to concrete shrinkage and creep. Hitherto, unified formulations for the structural behaviour of these members have not been properly developed. The proposal seeks to build on a previous ARC DP of the investigator that produces significant results for static loading, by developing a sophisticated methodology to handle non-static dynamic loading and for shrinkage and creep. It will develop advanced mathematical tools to enable the safe and efficient design of a multiplicity of structures that is of benefit to on and offshore Australian technology.Read moreRead less
Mathematical and mechanical modeling of nano particulate flow. Nano particulates are the basis for many new technologies, including coatings in the electronics industry, composite materials and medical and pharmaceutical applications. Worldwide industrial competition is increasingly determined by our capacity to handle such highly cohesive materials, and to exploit their novel physical, chemical and mechanical characteristics. Devising handling mechanisms and understanding nano particulate flows ....Mathematical and mechanical modeling of nano particulate flow. Nano particulates are the basis for many new technologies, including coatings in the electronics industry, composite materials and medical and pharmaceutical applications. Worldwide industrial competition is increasingly determined by our capacity to handle such highly cohesive materials, and to exploit their novel physical, chemical and mechanical characteristics. Devising handling mechanisms and understanding nano particulate flows depends on formulating accurate mathematical models which reflect the correct underlying physics. This APF proposal will utilise advanced continuum mechanics to develop the correct underlying conceptual ideas to resolve fundamental nanomechanical particulate flows, which will lead to the next generation of engineering tools.
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Unified nondeterministic dynamic safety assessment of softening structures. This project aims to develop a high-performance tool for the dynamic safety assessment of softening structures. The assessment of structures that exhibit softening, either at constitutive level or structural level, is essential for design and rehabilitation purposes, especially when the inevitable uncertainties in the system parameters need to be accounted for. This project aims to develop an advanced and unified framewo ....Unified nondeterministic dynamic safety assessment of softening structures. This project aims to develop a high-performance tool for the dynamic safety assessment of softening structures. The assessment of structures that exhibit softening, either at constitutive level or structural level, is essential for design and rehabilitation purposes, especially when the inevitable uncertainties in the system parameters need to be accounted for. This project aims to develop an advanced and unified framework that can model both stochastic and nonstochastic processes for these purposes. An advanced mixed finite element model underpins this framework, and both formulation and solution algorithms are based on mathematical programming formalism. The developed computational tool would be able to perform pure stochastic, pure nonstochastic, hybrid uncertain analyses and dynamic reliability assessment of structures.Read moreRead less
Three-dimensional contact and fracture analysis for safety assessment of structures. This project aims to address the safety assessment of engineering structures considering interfaces and cracks, which are nearly always the weakest parts of a structure system. Novel numerical approaches to model the contact of interfaces and crack faces and to simulate crack propagation under variable loads will be established based on the scaled boundary polytope elements and mathematical programming. It is an ....Three-dimensional contact and fracture analysis for safety assessment of structures. This project aims to address the safety assessment of engineering structures considering interfaces and cracks, which are nearly always the weakest parts of a structure system. Novel numerical approaches to model the contact of interfaces and crack faces and to simulate crack propagation under variable loads will be established based on the scaled boundary polytope elements and mathematical programming. It is anticipated that the developed numerical simulation tool will be robust and fully automatic. The intended outcome of this project is an innovative technology for numerical simulation and a rational predictive tool useful for cost-effective and timely planning, design and management of engineering structures.Read moreRead less
Stochastic geometrically nonlinear elasto-plastic buckling and behaviour of curved grid-like structures. It is vital to assess the safety of large spatially curved-complex structures for design and rehabilitation purposes when the inevitable uncertainties in structural parameters and loads are addressed. This project aims to develop an advanced stochastic framework for three-dimensional nonlinear elasto-plastic behaviour and buckling analysis of curved grid-like structures. A rational and powerf ....Stochastic geometrically nonlinear elasto-plastic buckling and behaviour of curved grid-like structures. It is vital to assess the safety of large spatially curved-complex structures for design and rehabilitation purposes when the inevitable uncertainties in structural parameters and loads are addressed. This project aims to develop an advanced stochastic framework for three-dimensional nonlinear elasto-plastic behaviour and buckling analysis of curved grid-like structures. A rational and powerful stochastic nonlinear elasto-plastic finite element model will be proposed to account for the random high-order geometric nonlinearity and material elasto-plasticity. Novel formulations and effective algorithms will also be devised for stochastic nonlinear analytical analysis. An efficient tool will be developed for reliability assessment of the class of structures.Read moreRead less
Scaled boundary finite-element approach for safety assessment of plates and shells under monotonic and shakedown loadings. This project develops an advanced numerical tool for the safety assessment of plate and shell structures under practical loading regimes. This tool permits timely decision making and is of vital assistance to engineers and government authorities on safe and cost-effective management of infrastructure asset.