Revealing the evolutionary and ecological dynamics of avian influenza virus. This project aims to understand how avian influenza virus (AIV) emerges, evolves and spreads in wild birds. AIV has the potential to devastate the poultry industry and cause human pandemics, but the factors that shape the genetic diversity of AIV in its wild bird reservoir are poorly understood. The project plans to combine genomic, ecological and phylogenetic approaches to reveal key aspects of AIV evolution, as well a ....Revealing the evolutionary and ecological dynamics of avian influenza virus. This project aims to understand how avian influenza virus (AIV) emerges, evolves and spreads in wild birds. AIV has the potential to devastate the poultry industry and cause human pandemics, but the factors that shape the genetic diversity of AIV in its wild bird reservoir are poorly understood. The project plans to combine genomic, ecological and phylogenetic approaches to reveal key aspects of AIV evolution, as well as the risk for future viral emergence. Using sampling sites in Australia and Antarctica, it plans to investigate AIV diversity, the evolutionary dynamics of AIV in wild birds and poultry, and the role played by environmental transmission in AIV ecology.Read moreRead less
Talent Mismatch: Evidence from Australian Administrative Tax Records. The project aims to study the skill composition of the Australian workforce. Changes in the macroeconomic and technology environments make it hard to predict skill shortage. The project expects to develop macroeconomic models quantifying skill-mismatch of university graduates, identify sources of mismatch, highlight gender and generational differences, and estimate associated costs to Australia. The expected outcomes are to he ....Talent Mismatch: Evidence from Australian Administrative Tax Records. The project aims to study the skill composition of the Australian workforce. Changes in the macroeconomic and technology environments make it hard to predict skill shortage. The project expects to develop macroeconomic models quantifying skill-mismatch of university graduates, identify sources of mismatch, highlight gender and generational differences, and estimate associated costs to Australia. The expected outcomes are to help shape policy recommendations on the funding of tertiary education in a changing economic climate. This should provide significant benefits to Australians, as policies shaping the tertiary education system affect individual income and the aggregate economy by determining labour supply and taxpayers' financial burden.Read moreRead less
Transnationalism and diaspora. This study aims to incorporate diaspora, circular migration and transnational linkages into demographic concepts of population and migration. Transnationalism’s replacement of permanent movements as the dominant paradigm in migration studies raises questions for demographic measurement and the study of migration. This project will use traditional demographic data with integrated quantitative and qualitative research to analyse the diaspora–migration–development nex ....Transnationalism and diaspora. This study aims to incorporate diaspora, circular migration and transnational linkages into demographic concepts of population and migration. Transnationalism’s replacement of permanent movements as the dominant paradigm in migration studies raises questions for demographic measurement and the study of migration. This project will use traditional demographic data with integrated quantitative and qualitative research to analyse the diaspora–migration–development nexus. It will study four countries to understand the characteristics of diasporas, their international linkages and their potential for enhancing development in origin countries. This is expected to generate policy advice on how to maximise the economic potential of diaspora.Read moreRead less
Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family protei ....Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family proteins as specific effectors. This project will address a new paradigm in genetics that is likely to underpin development.Read moreRead less
Controlling the adhesome to regulate cell fate on biomaterials. Mesenchymal stem cell-based tissue engineering practices are hampered worldwide by the lack of appreciation and understanding of the matrix-mediated cues that must be provided during adhesion and spreading to drive cells to definitive tissue end points. This project will address these knowledge deficiencies by combining high throughput array technologies, a set of tailorable self-assembling biomaterials and real-time biosensors to r ....Controlling the adhesome to regulate cell fate on biomaterials. Mesenchymal stem cell-based tissue engineering practices are hampered worldwide by the lack of appreciation and understanding of the matrix-mediated cues that must be provided during adhesion and spreading to drive cells to definitive tissue end points. This project will address these knowledge deficiencies by combining high throughput array technologies, a set of tailorable self-assembling biomaterials and real-time biosensors to rapidly, at high resolution, elucidate how mechanotransductive cues determine the fate choice of mesenchymal stem cells, and furthermore, how to manipulate them with smart biomaterial design to achieve desired outcomes for tissue engineering. Read moreRead less
Molecular dissection of the functional regions of genes that encode actinins (ACTN2 and ACTN3) and their contribution to normal variation in skeletal muscle function. The project has discovered a common genetic variant that affects skeletal muscle structure, function and metabolism and influences athletic ability, and response to diet and exercise. The project will study how this gene influences muscle bulk and strength, the metabolic efficiency of muscle and the risk of obesity in the general ....Molecular dissection of the functional regions of genes that encode actinins (ACTN2 and ACTN3) and their contribution to normal variation in skeletal muscle function. The project has discovered a common genetic variant that affects skeletal muscle structure, function and metabolism and influences athletic ability, and response to diet and exercise. The project will study how this gene influences muscle bulk and strength, the metabolic efficiency of muscle and the risk of obesity in the general population.Read moreRead less
Power system security assessment given massive intermittent energy sources. This project aims to develop new models and analysis methods to investigate the impact of massive intermittent energy sources (IESs) on the performance and security of power grids. Furthermore, advanced control strategies will be developed to enhance the security. The outcomes can provide useful guidelines to assist the Australian power industry and the government in realising the renewable energy target. Furthermore con ....Power system security assessment given massive intermittent energy sources. This project aims to develop new models and analysis methods to investigate the impact of massive intermittent energy sources (IESs) on the performance and security of power grids. Furthermore, advanced control strategies will be developed to enhance the security. The outcomes can provide useful guidelines to assist the Australian power industry and the government in realising the renewable energy target. Furthermore considering serious blackout can not only cause economic losses, but also larger disturbance in other critical infrastructure, this project also contributes to national security.Read moreRead less
Advanced inverter control for distributed energy systems. This project aims to discover innovative fundamental approaches for the control of electrical grids with a diverse and changing mix of generation sources. It will generate new knowledge in the area of electrical power system control by researching innovative and advanced inverter control techniques coupled to advanced power system models. The expected outcomes are advanced power system control techniques that remove the emerging barriers ....Advanced inverter control for distributed energy systems. This project aims to discover innovative fundamental approaches for the control of electrical grids with a diverse and changing mix of generation sources. It will generate new knowledge in the area of electrical power system control by researching innovative and advanced inverter control techniques coupled to advanced power system models. The expected outcomes are advanced power system control techniques that remove the emerging barriers to increased penetrations of distributed generation and energy storage. The benefit of the research includes an Australian-developed solution to many of the difficulties faced by grid operators around the world in incorporating increased renewable generation and energy storage in their power systems.Read moreRead less
Customer Centred Peer-to-Peer Energy Trading Framework for Future Grids. This project aims to develop a peer-to-peer (P2P) energy trading framework that facilitates cooperative and trustworthy energy trading directly among energy customers such as residents. By developing novel energy load monitoring and prediction techniques, a customer cooperation scheme and a privacy-preserving P2P energy market, this project expects to transform current energy networks to facilitate energy trading at the edg ....Customer Centred Peer-to-Peer Energy Trading Framework for Future Grids. This project aims to develop a peer-to-peer (P2P) energy trading framework that facilitates cooperative and trustworthy energy trading directly among energy customers such as residents. By developing novel energy load monitoring and prediction techniques, a customer cooperation scheme and a privacy-preserving P2P energy market, this project expects to transform current energy networks to facilitate energy trading at the edge of the grid and contribute to achievement of Australia’s net-zero emission target by 2050. The intended outcomes form this project include new science and knowledge of customer-side energy systems, new design philosophy and strategies for energy markets, and an open-source framework for prototype evaluation. Read moreRead less
Developing the basis for an quality control platform for human pluripotent stem cells and their differentiated derivatives. Biophotonic techniques based on spectroscopy have the potential to provide low-cost, automatable measurements for the quality control of stem and differentiated cells produced for use in industry and regenerative medicine. This project is aimed at acquiring the fundamental scientific knowledge base required to bring this about.