Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family protei ....Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family proteins as specific effectors. This project will address a new paradigm in genetics that is likely to underpin development.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC170100016
Funder
Australian Research Council
Funding Amount
$3,123,492.00
Summary
ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therap ....ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therapeutics. The use of an individual patient’s cellular and molecular research findings will ultimately enable personalised diagnostic and therapeutic decisions.Read moreRead less
Measuring the impact of urban regulation on housing affordability in Australian cities and regions. Urban planning must ensure that development meets new environmental goals, but stringent regulation may reduce housing supply and affordability. This project uses new local planning data and econometric studies to quantify and monitor planning regulation impacts on housing supply and affordability in Australian cities and regions.
Special Research Initiatives - Grant ID: SR1101002
Funder
Australian Research Council
Funding Amount
$21,000,000.00
Summary
Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and ....Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC190100026
Funder
Australian Research Council
Funding Amount
$4,969,663.00
Summary
ARC Training Centre for Cell and Tissue Engineering Technologies. The ARC Training Centre for Cell and Tissue Engineering Technologies aims to provide training to create a highly skilled workforce for the tissue engineering and regenerative medicine sector and to enhance research performance and innovation in Australia through fundamental and applied research carried out in industry-led PhD projects. The research aims to address major aspects of the manufacturing and commercialisation pathway an ....ARC Training Centre for Cell and Tissue Engineering Technologies. The ARC Training Centre for Cell and Tissue Engineering Technologies aims to provide training to create a highly skilled workforce for the tissue engineering and regenerative medicine sector and to enhance research performance and innovation in Australia through fundamental and applied research carried out in industry-led PhD projects. The research aims to address major aspects of the manufacturing and commercialisation pathway and barriers faced by the sector, namely improving process efficiencies, enabling early-stage scale-up (cell/tissue) and development of the sector's supply chain. The knowledge created and research undertaken would help to accelerate commercialisation in regenerative medicine, tissue engineering and cell therapies.Read moreRead less
Engaging Students during the Early Years of Secondary School. This project aims to design, test and share sustainable strategies to support teachers and enable students from low socioeconomic communities to achieve success. The greatest decreases in students’ interest and effort occur when they transition into secondary school, with students from low socioeconomic communities at greatest risk of disengagement. What can teachers do to engage their students during this key life transition? This pr ....Engaging Students during the Early Years of Secondary School. This project aims to design, test and share sustainable strategies to support teachers and enable students from low socioeconomic communities to achieve success. The greatest decreases in students’ interest and effort occur when they transition into secondary school, with students from low socioeconomic communities at greatest risk of disengagement. What can teachers do to engage their students during this key life transition? This project plans to identify teacher behaviours that motivate students in their first year at secondary school. Using an experimental design with a representative sample of 150 teachers and 1500 students in low socioeconomic areas across three states, the project plans to test whether an online professional learning program for teachers can improve student engagement and achievement. This cost-effective and scalable intervention is designed for widespread dissemination to Australian teachers.Read moreRead less
Group A Streptococcal Human Challenge Study: Accelerating Vaccine Development
Funder
National Health and Medical Research Council
Funding Amount
$2,018,741.00
Summary
Infection with group A streptococcus (GAS) is a major cause of morbidity and mortality worldwide, including in the Aboriginal population of Australia. Concerted efforts for vaccine development have been hampered by the absence of a suitable animal model. To address this critical knowledge gap we propose to develop a controlled human infection model of GAS infection. This model will provide a direct pathway for the future appraisal of novel GAS vaccines.
Investigating literary knowledge in the making of English teachers. This project aims to create new understanding of the role of literary knowledge within subject English. English education is mandated in Australian schooling; however, subject content as well as teachers’ knowledge and pedagogical approaches are highly contested, particularly regarding the teaching of literature. Using a national survey, focus group interviews and a longitudinal study, the project aims to provide new understandi ....Investigating literary knowledge in the making of English teachers. This project aims to create new understanding of the role of literary knowledge within subject English. English education is mandated in Australian schooling; however, subject content as well as teachers’ knowledge and pedagogical approaches are highly contested, particularly regarding the teaching of literature. Using a national survey, focus group interviews and a longitudinal study, the project aims to provide new understandings of the literary knowledge that early career teachers need, of the impact of curricula and professional practice on disciplinary knowledge, and about the operation of literary studies across school and university. Significantly, it plans to use ‘literary sociability’, an innovative methodology, to generate empirical and conceptual perspectives on literary studies in Australia that will be of value internationally.Read moreRead less
Innovative measurement approaches to optimise the comparability of large-scale and high-stakes performance assessments. Over 1.2 million Australian school children participate in national and high-stakes state assessments each year. This project aims to produce improved and novel methods for assessing students using open-ended tasks so that educators can more accurately compare students’ achievements and track their progress. In turn, this aims to support decision makers to enable better educati ....Innovative measurement approaches to optimise the comparability of large-scale and high-stakes performance assessments. Over 1.2 million Australian school children participate in national and high-stakes state assessments each year. This project aims to produce improved and novel methods for assessing students using open-ended tasks so that educators can more accurately compare students’ achievements and track their progress. In turn, this aims to support decision makers to enable better educational outcomes. The investigators aim to refine a rubric used in the National Assessment Program—Literacy and Numeracy (NAPLAN) so that Writing assessments are as accurate and comparable as possible. Methods also aim to be designed to enable more accurate and comparable assessments of Australian children in areas not covered by NAPLAN such as History and The Arts.Read moreRead less
Reducing The Effects Of Antenatal Alcohol On Child Health (REAACH)
Funder
National Health and Medical Research Council
Funding Amount
$2,497,397.00
Summary
Use of alcohol in pregnancy can affect the developing baby and cause Fetal Alcohol Spectrum Disorders (FASD). Children with FASD have lifelong brain injury that can lead to poor school performance, poor mental health and trouble with the law. This CRE builds on our strong background in research and community engagement to improve FASD prevention, diagnosis and treatment across Australia.