Photoreversible hydrogels to study stem cell memory and fate. This project will develop materials whose stiffness can be reversibly increased and decreased by the simple application of light, and use these to build knowledge of how stem cell fate is regulated. The influence of mechanical cues on the structure and organisation of the nucleus will be determined. Expected outcomes are new synthetic and light-reversible culture materials, and fundamental insights into how forces change the nucleus t ....Photoreversible hydrogels to study stem cell memory and fate. This project will develop materials whose stiffness can be reversibly increased and decreased by the simple application of light, and use these to build knowledge of how stem cell fate is regulated. The influence of mechanical cues on the structure and organisation of the nucleus will be determined. Expected outcomes are new synthetic and light-reversible culture materials, and fundamental insights into how forces change the nucleus to alter stem cell aging and fate. The findings will provide critical information required for the future development of assays to measure cell potency and instructive biomaterials to drive stem cell expansion and tissue-regeneration and will have impact by underpinning future advances in stem cell technologies.Read moreRead less
A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological respon ....A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological response from the nasal mucosa. The aim is to overcome a key fabrication challenge - to 3D print an anatomically accurate nasal construct with a porous wall on which to grow and mature functional nasal tissue that lines a nasal cavity wall. The benefit would be enabling faster development of more targeted drugs and vaccines.Read moreRead less
Dual Stimulation Approach to Stem Cell Based Tissue Engineering. This Project aims to determine how human stem cells differentiate into different cell types in response to electrical and mechanical stimulation on a conductive biomaterial platform, and to use this knowledge to develop a custom built bioreactor. It expects to generate new insight into the mechanisms that control stem cell fate using innovative single cell measurements, and will deliver a bioreactor capable of using these mechanism ....Dual Stimulation Approach to Stem Cell Based Tissue Engineering. This Project aims to determine how human stem cells differentiate into different cell types in response to electrical and mechanical stimulation on a conductive biomaterial platform, and to use this knowledge to develop a custom built bioreactor. It expects to generate new insight into the mechanisms that control stem cell fate using innovative single cell measurements, and will deliver a bioreactor capable of using these mechanisms for large scale stem cell differentiation. The expected outcomes are a significant advancement in knowledge in the field of tissue engineering and more efficient methodology for patient-derived stem cell therapy. This will provide new pathways to improving stem cell therapy for tissue engineering applications.Read moreRead less
Early career teacher induction: Supporting precarious teachers. This project aims to investigate the ways in which Australian induction policies support precariously employed early career teachers to effectively manage student classroom behaviour. This project expects to generate new knowledge of workforce development and induction experiences of early career teachers employed on casual and short-term contracts. Expected outcomes of this project include alternative policy and practice recommenda ....Early career teacher induction: Supporting precarious teachers. This project aims to investigate the ways in which Australian induction policies support precariously employed early career teachers to effectively manage student classroom behaviour. This project expects to generate new knowledge of workforce development and induction experiences of early career teachers employed on casual and short-term contracts. Expected outcomes of this project include alternative policy and practice recommendations to support the transition of insecure replacement teachers within the profession. The benefits of this research include, improving teachers’ classroom management practices; the retention of new teachers; improving teacher workforce development; and building a healthier education system. Read moreRead less
How do transcription factors control cell fate transitions? The aim of this project is to determine how transcription factors control cellular identity, which is relevant to many biological processes including embryogenesis, cellular reprogramming and differentiation. Innovative genomic tools will be combined with various in vitro cellular conversion systems to generate fundamental mechanistic insight into how transcription factors mediate these identity changes. The knowledge gained from this w ....How do transcription factors control cell fate transitions? The aim of this project is to determine how transcription factors control cellular identity, which is relevant to many biological processes including embryogenesis, cellular reprogramming and differentiation. Innovative genomic tools will be combined with various in vitro cellular conversion systems to generate fundamental mechanistic insight into how transcription factors mediate these identity changes. The knowledge gained from this work will allow us to answer standing fundamental questions in regards to cell fate control and the biochemistry of transcription factors, which in turn will aid in the development of novel gene regulation technologies applicable to a myriad of fields and industries.Read moreRead less
Teacher capabilities in conditions of superdiversity. The increasing diversity of students in schools presents a significant challenge for the professional education and practice of teachers. The project aims to develop an original approach to measuring teacher capabilities to respond to and engage with difference. Its expected significance is in building new knowledge about teacher workforce development to achieve education goals and social cohesion in conditions of superdiversity. The project' ....Teacher capabilities in conditions of superdiversity. The increasing diversity of students in schools presents a significant challenge for the professional education and practice of teachers. The project aims to develop an original approach to measuring teacher capabilities to respond to and engage with difference. Its expected significance is in building new knowledge about teacher workforce development to achieve education goals and social cohesion in conditions of superdiversity. The project's expected outcomes include a metric of teacher capabilities that can inform the professional education of teachers and policy settings in this country and internationally. This large-scale study should return real benefits to ensure successful education and well-being of diverse students.Read moreRead less
Equipping Australian teachers today to face AI tomorrow. Applications of Artificial Intelligence (AI) are set to transform society, including how people work and learn. Yet there is very little research about what Australian teachers need to know in order to prepare students to thrive in an AI-rich society and workforce. This study aims to construct a foundational understanding for teaching with and about AI. It will also show how to develop effective networks to empower teachers as active chang ....Equipping Australian teachers today to face AI tomorrow. Applications of Artificial Intelligence (AI) are set to transform society, including how people work and learn. Yet there is very little research about what Australian teachers need to know in order to prepare students to thrive in an AI-rich society and workforce. This study aims to construct a foundational understanding for teaching with and about AI. It will also show how to develop effective networks to empower teachers as active change agents. The expected outcomes will equip teachers with the knowledge and resources to lead the development of Australia’s future AI capability, including through enhanced classroom practices and more creative teacher networks.Read moreRead less
Feedback literacy for effective learning at university and beyond. This project aims to develop frameworks and strategies that help learners make the most of feedback across their studies and into their working lives. Using behaviour change techniques from the health and social sciences, the project expects to develop ways to support students and graduates to seek out and use feedback, and to manage their emotions throughout the feedback process. Expected outcomes of this project include evidenc ....Feedback literacy for effective learning at university and beyond. This project aims to develop frameworks and strategies that help learners make the most of feedback across their studies and into their working lives. Using behaviour change techniques from the health and social sciences, the project expects to develop ways to support students and graduates to seek out and use feedback, and to manage their emotions throughout the feedback process. Expected outcomes of this project include evidence-informed strategies that individuals and institutions can use to develop life-long capabilities to make the most of feedback. This should provide significant benefits across all sectors of Australian society, where productivity, learning and wellbeing depend on healthy and effective engagement with feedback.Read moreRead less
Enacting Climate Change Education through representing scientists’ practice. This research will work with scientists and teachers across three continents to translate contemporary climate-related research practices into a novel curriculum approach that emphasises deep science knowledge, skills, and values. It responds to a pressing national need to prepare students for a 21st century marked by complex work futures and major socio-scientific challenges related to climate change. The project will ....Enacting Climate Change Education through representing scientists’ practice. This research will work with scientists and teachers across three continents to translate contemporary climate-related research practices into a novel curriculum approach that emphasises deep science knowledge, skills, and values. It responds to a pressing national need to prepare students for a 21st century marked by complex work futures and major socio-scientific challenges related to climate change. The project will develop students’ engagement with and competencies in the sciences for fast changing work futures, and decision making and action regarding environmental challenges. It contributes to an enhanced scientific workforce and a citizenry capable of responding to complex environment-related challenges.
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Supporting teachers and teaching in the age of Artificial Intelligence. This project aims to investigate teacher capabilities to respond to, and engage with, Artificial Intelligence (AI) tools in their classrooms and online teaching. This project expects to generate significant new knowledge about teacher workforce development to work productively alongside AI and other automated technologies. Expected outcomes include insights into technical, organisational and social issues surrounding the dep ....Supporting teachers and teaching in the age of Artificial Intelligence. This project aims to investigate teacher capabilities to respond to, and engage with, Artificial Intelligence (AI) tools in their classrooms and online teaching. This project expects to generate significant new knowledge about teacher workforce development to work productively alongside AI and other automated technologies. Expected outcomes include insights into technical, organisational and social issues surrounding the deployment of AI tools in schools, and the development of models of AI best practice and professional learning. This should provide significant benefits such as improved classroom outcomes and better use of technical infrastructure investment.Read moreRead less