A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological respon ....A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological response from the nasal mucosa. The aim is to overcome a key fabrication challenge - to 3D print an anatomically accurate nasal construct with a porous wall on which to grow and mature functional nasal tissue that lines a nasal cavity wall. The benefit would be enabling faster development of more targeted drugs and vaccines.Read moreRead less
Understanding the differentiation of the endocardium. The project aims to understand the genetic regulation of endocardial development. The heart is essential for survival, its beat the indicator of life. The endocardium, the heart’s inner lining, is required for signalling during heart development and is a major component of the valves, septa and trabeculae. Despite its indispensable role, little is known about how it forms or develops. This project integrates two complementary approaches that ....Understanding the differentiation of the endocardium. The project aims to understand the genetic regulation of endocardial development. The heart is essential for survival, its beat the indicator of life. The endocardium, the heart’s inner lining, is required for signalling during heart development and is a major component of the valves, septa and trabeculae. Despite its indispensable role, little is known about how it forms or develops. This project integrates two complementary approaches that have identified the earliest marker of endocardial differentiation and devised the method to make endocardium from stem cells. Knowledge from this work will inform future research into growing and regenerating damaged tissue.Read moreRead less
Early career teacher induction: Supporting precarious teachers. This project aims to investigate the ways in which Australian induction policies support precariously employed early career teachers to effectively manage student classroom behaviour. This project expects to generate new knowledge of workforce development and induction experiences of early career teachers employed on casual and short-term contracts. Expected outcomes of this project include alternative policy and practice recommenda ....Early career teacher induction: Supporting precarious teachers. This project aims to investigate the ways in which Australian induction policies support precariously employed early career teachers to effectively manage student classroom behaviour. This project expects to generate new knowledge of workforce development and induction experiences of early career teachers employed on casual and short-term contracts. Expected outcomes of this project include alternative policy and practice recommendations to support the transition of insecure replacement teachers within the profession. The benefits of this research include, improving teachers’ classroom management practices; the retention of new teachers; improving teacher workforce development; and building a healthier education system. Read moreRead less
Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family protei ....Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family proteins as specific effectors. This project will address a new paradigm in genetics that is likely to underpin development.Read moreRead less
Naming the world: early years literacy and sustainability learning. The project seeks to produce knowledge about new forms of literacy emerging in sustainability education. For children born in the 21st century, the enmeshing of natural and human forces in the survival of the planet requires conceptual and practical innovation. Early childhood education can be a fundamental driver in this process. This project aims to integrate literacy and sustainability to produce powerful new learning for you ....Naming the world: early years literacy and sustainability learning. The project seeks to produce knowledge about new forms of literacy emerging in sustainability education. For children born in the 21st century, the enmeshing of natural and human forces in the survival of the planet requires conceptual and practical innovation. Early childhood education can be a fundamental driver in this process. This project aims to integrate literacy and sustainability to produce powerful new learning for young children. It plans to theorise new forms of literacy emerging in sustainability education, articulate innovative pedagogies, and inform national and international policy and practice to address 21st century learning imperatives.Read moreRead less
Controlling the adhesome to regulate cell fate on biomaterials. Mesenchymal stem cell-based tissue engineering practices are hampered worldwide by the lack of appreciation and understanding of the matrix-mediated cues that must be provided during adhesion and spreading to drive cells to definitive tissue end points. This project will address these knowledge deficiencies by combining high throughput array technologies, a set of tailorable self-assembling biomaterials and real-time biosensors to r ....Controlling the adhesome to regulate cell fate on biomaterials. Mesenchymal stem cell-based tissue engineering practices are hampered worldwide by the lack of appreciation and understanding of the matrix-mediated cues that must be provided during adhesion and spreading to drive cells to definitive tissue end points. This project will address these knowledge deficiencies by combining high throughput array technologies, a set of tailorable self-assembling biomaterials and real-time biosensors to rapidly, at high resolution, elucidate how mechanotransductive cues determine the fate choice of mesenchymal stem cells, and furthermore, how to manipulate them with smart biomaterial design to achieve desired outcomes for tissue engineering. Read moreRead less
Education meets play: a sociological study of how the new compulsory national learning framework for children zero to five years influences educators' practice. New theorising about play and education in early childhood settings has challenged traditional notions of play. This project investigates how educators respond to the requirement for play-based learning by identifying characteristics of successful educators and professional leaders, and strategies and practices that merge education and p ....Education meets play: a sociological study of how the new compulsory national learning framework for children zero to five years influences educators' practice. New theorising about play and education in early childhood settings has challenged traditional notions of play. This project investigates how educators respond to the requirement for play-based learning by identifying characteristics of successful educators and professional leaders, and strategies and practices that merge education and play.Read moreRead less
Social justice dispositions informing teachers' pedagogy in advantaged and disadvantaged secondary schools. This project studies the different perspectives that teachers have towards social justice and how these differently influence their teaching in advantaged and disadvantaged secondary schools. It will produce new concepts and methods for researching educational inequalities and to better enable teachers to act in more socially just ways.
Learning-rich leadership for quality improvement in early education. This project aims to establish Australia's first evidence base to inform quality improvement in early childhood education services through the development of educational leaders. Effective leadership is essential to ensuring the effective implementation of the Australian government's national quality standards for early childhood education. A new theory of 'learning-rich' leadership for quality improvement will be developed to ....Learning-rich leadership for quality improvement in early education. This project aims to establish Australia's first evidence base to inform quality improvement in early childhood education services through the development of educational leaders. Effective leadership is essential to ensuring the effective implementation of the Australian government's national quality standards for early childhood education. A new theory of 'learning-rich' leadership for quality improvement will be developed to influence leadership education in the early childhood sector. Expected outcomes from this project have potential benefits for the increased effectiveness in service quality for early childhood education.Read moreRead less
Shifting the Culture of Out-of-field Professional Education for Teachers. This project aims to model an education system that would diversify the expertise of teachers as part of attending to long-term teacher shortage. It responds to a pressing national need for a system of valued and accessible professional education (PE) for out-of-field teachers. The project draws on perspectives from schools, governments and PE providers to expose current practices, cultural norms, and policies; propose an ....Shifting the Culture of Out-of-field Professional Education for Teachers. This project aims to model an education system that would diversify the expertise of teachers as part of attending to long-term teacher shortage. It responds to a pressing national need for a system of valued and accessible professional education (PE) for out-of-field teachers. The project draws on perspectives from schools, governments and PE providers to expose current practices, cultural norms, and policies; propose an 'ideal' PE ecosystem that values re-specialisation in the core subjects; and develop principles to inform policy and practice needed to attain this ideal. The evidence-based framing of PE will inform efforts by schools, PE providers and policy makers to sustain a highly capable, adaptive and specialised teaching workforce.Read moreRead less