Understanding The Regulation Of HERG Potassium Channel In The Myometrium At The Time Of Labour
Funder
National Health and Medical Research Council
Funding Amount
$597,661.00
Summary
We have shown that a potassium channel known as hERG falls precipitously at the time of term labour and that blocking this channel causes powerful uterine contractions. This grant will determine how the expression of this channel is regulated in the myometrium and whether changes in hERG channels also occur in premature labour.
Understanding The Myometrial Transition At Term And Preterm Labour To Guide Tocolysis
Funder
National Health and Medical Research Council
Funding Amount
$808,447.00
Summary
This grant seeks to understand how the muscle cells of the uterus transform at the time of labour. We propose that this transformation is organised by enzymes that modify the histones around key genes. We will test if a similar pathway operates in cases of preterm labour. The results will guide the development of new ways of treating premature labour that will use targeted nanoparticles to deliver siRNA directly to the muscle cells of the uterus.
Optimising Future Human Health By Optimising Birth Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$876,005.00
Summary
Laureate Professor Smith received an AM for his research on human pregnancy and contributions to Indigenous maternal health. His research has dramatically expanded in the last 5 years to include stillbirth, viral infections during pregnancy, early detection of renal disease, the development of targeted nanoparticles for delivery of therapeutics to the uterus, and data-linkage to test the impact of antenatal care. His research seeks to optimise the health of pregnant women and their children.
Australian labour market adjustment to technology, trade and policy. This project aims to examine how the Australian labour market has adjusted over the past 30 years to several major developments: increased use of computers, growth in international trade and the mining boom, microeconomic reform, and the expansion of higher education. The analysis is designed to encompass the effect on labour market outcomes including workers’ pay, the skill composition of employment, migration flows and indivi ....Australian labour market adjustment to technology, trade and policy. This project aims to examine how the Australian labour market has adjusted over the past 30 years to several major developments: increased use of computers, growth in international trade and the mining boom, microeconomic reform, and the expansion of higher education. The analysis is designed to encompass the effect on labour market outcomes including workers’ pay, the skill composition of employment, migration flows and individuals’ decisions about acquiring education. Having a richer understanding of how the labour market has adjusted in the past may help policy-makers to infer how adjustment will happen in the future. For example, a better understanding of the effects of new technologies would provide a stronger basis for judging trends in job creation and hence the types of skills and training that will be required in Australia in future years.Read moreRead less
Economic stress, non-cognitive skill development and life outcomes. This project aims to identify policies in which the fostering of non-cognitive skills (NCS) can break the persistence of economic disadvantage. The project seeks to investigate the mechanisms behind differential development, intergenerational transmission of NCS between "rich and poor," how exposure to economic stress inhibits NCS development and the role of schooling in boosting NCS of disadvantaged children. Expected outcomes ....Economic stress, non-cognitive skill development and life outcomes. This project aims to identify policies in which the fostering of non-cognitive skills (NCS) can break the persistence of economic disadvantage. The project seeks to investigate the mechanisms behind differential development, intergenerational transmission of NCS between "rich and poor," how exposure to economic stress inhibits NCS development and the role of schooling in boosting NCS of disadvantaged children. Expected outcomes include evidence-based policy advice on how human capital investments in NCS can be beneficial for health, educational and labour market success, and how NCS can survive despite economic stress. Intended benefits include new cost-effective policies to reduce inequality and maximise the welfare of society.Read moreRead less
Randomised Controlled Trial Of Early Intervention To Improve Sexual And Couple Functioning After Prostate Cancer
Funder
National Health and Medical Research Council
Funding Amount
$405,000.00
Summary
Treatment for localised prostate cancer has a long term negative impact on the sexuality, quality of life, and relationship quality of Australian men and their intimate partners. This study will trial a remote access couples based sexuality intervention for this patient and carer group that has potential for broader translation into community and acute health care settings. This approach will also have broader application for chronic disease self management for other health conditions.
Characterisation Of Immune Regulators In The Human Myometrium.
Funder
National Health and Medical Research Council
Funding Amount
$85,285.00
Summary
Premature birth is a major cause of perinatal death and morbidity. It further predisposes the individual to increased morbidity throughout life. Although the mechanism of birth has been heavily researched with an objective of preventing preterm babies, it is still not fully understood. A major problem has been the lack of suitable and accessible animal models. A key organ coordinating the birth event is the uterine smooth muscle, myometrium. For effective birth and delivery, the myometrium needs ....Premature birth is a major cause of perinatal death and morbidity. It further predisposes the individual to increased morbidity throughout life. Although the mechanism of birth has been heavily researched with an objective of preventing preterm babies, it is still not fully understood. A major problem has been the lack of suitable and accessible animal models. A key organ coordinating the birth event is the uterine smooth muscle, myometrium. For effective birth and delivery, the myometrium needs to be contracting synchronously in a coordinated manner to dilate the cervix while pushing the fetus into position for eventual delivery through the birth canal. This project aims to characterise the molecular events occurring at the myometrium which precedes and precipitates labour. These local changes will be linked with the systemic hormonal changes in order to approach a model for human parturition.Read moreRead less