Determinants Of Occurrence And Progression Of Aortic Stenosis In Bicuspid And Tricuspid Valves.
Funder
National Health and Medical Research Council
Funding Amount
$546,394.00
Summary
Aortic stenosis (AS) is a major cause of cardiac failure and mortality in ageing Australians. AS occurs both in bicuspid aortic valves (BAV;0.5-1% of the population) and in anatomically tricuspid valves. There is an associated incremental risk of myocardial infarction. The research will investigate patients with BAV and with early AS in tricuspid valves, in order to examine the potential roles of loss of nitric oxide effect and of oxidant stress as predictors of AS development.