Cellular genomic approach to the pathogenesis of multiple sclerosis. This project compares the levels of gene usage in two important immune cell types between patients with multiple sclerosis and people who do not have the disease. It aims to identify the molecular basis for the disease, in order to identify new diagnostic, preventative and treatment options.
Efficacy Of Education And Advice Delivered By Text Message To Aid Smoking Cessation
Funder
National Health and Medical Research Council
Funding Amount
$538,395.00
Summary
A high proportion of smokers indicate a desire to stop smoking and report having made attempts to quit. However, most attempts are not successful and new methods are needed to support motivated smokers and improve success rates. This project evaluates the use of text messages to deliver advice and support to smokers motivated to stop smoking. We aim to understand if and how this promosing new intervention helps smokers to quit.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100006
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
An adaptable and dedicated linear accelerator for medical radiation research. Leading radiation scientists developing innovative methods and devices for treating cancer patients will collaborate in future research using this highly adaptable linear accelerator for medical radiation research. Innovations in tumour targeting, better patient safety, new medical devices and improved cancer outcomes are expected.
Technology and innovation management in high risk situations. The value of Australian bulk commodity exports and container imports is expected to double from $400 billion to $800 billion by 2020, placing considerable pressure on port waters. This project will examine the challenge whereby port operators are both encouraged to take risks to innovate but are constrained by the consequences of risk.
Ultrasound in muscle vascular research, and gene therapy. This project focuses on ultrasound and microbubbles for the imaging of microvascular blood flow patterns in skeletal muscle and as a modality for drug delivery. The aim is to develop and refine technology specifically for (i) assessment of muscle microvascular flow in health and disease, and for (ii) delivery of state-of-the art gene constructs to endothelial cells that control blood flow in the muscle microvasculature. We anticipate impr ....Ultrasound in muscle vascular research, and gene therapy. This project focuses on ultrasound and microbubbles for the imaging of microvascular blood flow patterns in skeletal muscle and as a modality for drug delivery. The aim is to develop and refine technology specifically for (i) assessment of muscle microvascular flow in health and disease, and for (ii) delivery of state-of-the art gene constructs to endothelial cells that control blood flow in the muscle microvasculature. We anticipate improved technology for early diagnosis of impairment in microvascular flow relevant to muscle insulin resistance and novel therapeutics that improve muscle microvascular blood flow applicable to the treatment of diabetes.Read moreRead less
Inherited determinants of cancer aetiology. Family history of cancer is a strong risk factor for many cancers. This project will aim to identify inherited factors influencing risk of developing cancer and those factors influencing the course of the disease and outcomes.
Industrial Transformation Training Centres - Grant ID: IC190100033
Funder
Australian Research Council
Funding Amount
$3,852,568.00
Summary
ARC Training Centre for Transformation of Australia's Biosolids Resource. This Centre aims to bring together Australia’s leading biosolids researchers and key industry and government stakeholders to advance the management, transformation and reuse of biosolids in agriculture. The focus is: 1) capability and knowledge building, 2) research development, extension and training, 3) sustainable strategic partnerships. The expected outcomes of the Centre are to develop a group of new, highly-trained i ....ARC Training Centre for Transformation of Australia's Biosolids Resource. This Centre aims to bring together Australia’s leading biosolids researchers and key industry and government stakeholders to advance the management, transformation and reuse of biosolids in agriculture. The focus is: 1) capability and knowledge building, 2) research development, extension and training, 3) sustainable strategic partnerships. The expected outcomes of the Centre are to develop a group of new, highly-trained industry-ready researchers as well as advanced solutions in three major themes: improved technologies, enhanced products and sustainability. This will provide significant benefits in the economic value of new applications and market opportunities as well as deliver cost-savings – all in an environmentally friendly manner.Read moreRead less
The pharmacokinetics of plant secondary metabolites and their effects on feeding in the brushtail possum. Plant secondary metabolites (PSMs) are considered to protect against herbivory, although the mechanisms are not well understood. This project will determine how marsupial folivores avoid toxicity when browsing on Eucalyptus leaf. Blood levels of terpenes, phenols and their metabolites will be measured in the brushtail possum while it feeds on a diet of varying PSM content. We expect to be ab ....The pharmacokinetics of plant secondary metabolites and their effects on feeding in the brushtail possum. Plant secondary metabolites (PSMs) are considered to protect against herbivory, although the mechanisms are not well understood. This project will determine how marsupial folivores avoid toxicity when browsing on Eucalyptus leaf. Blood levels of terpenes, phenols and their metabolites will be measured in the brushtail possum while it feeds on a diet of varying PSM content. We expect to be able to show relationships between the ingestion and blood levels of PSMs and feeding behaviour. This will give a greater understanding of the effect of plant toxins on browsing behaviour, enabling improved foraging models and more effective habitat management.Read moreRead less
How does forestry impact headwater streams? Although headwater streams make up much of the catchment of rivers, the effects of forestry on instream species composition, habitat types, and ecosystem functions remain uninvestigated. We aim to fill these three gaps so that managers can: 1. determine whether stream side buffers are necessary and 2. identify which species and ecosystem functions are the most sensitive and reliable variables for future monitoring of instream ecosystem health.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0452281
Funder
Australian Research Council
Funding Amount
$102,900.00
Summary
Muscle Vascular Research and Gene Therapy Using Ultrasound. We seek funds to set up a national facility for ultrasound in muscle vascular research and gene therapy. Ultrasound with microbubbles will be used for the imaging of muscle microvascular blood flow and as a delivery modality for gene constructs to endothelial cells that control blood flow. The technology has application to (i) the assessment and therapeutic treatment of impaired microvascular function as in diabetics; (ii) the assessmen ....Muscle Vascular Research and Gene Therapy Using Ultrasound. We seek funds to set up a national facility for ultrasound in muscle vascular research and gene therapy. Ultrasound with microbubbles will be used for the imaging of muscle microvascular blood flow and as a delivery modality for gene constructs to endothelial cells that control blood flow. The technology has application to (i) the assessment and therapeutic treatment of impaired microvascular function as in diabetics; (ii) the assessment of adaptation to physical training and (iii) the development of therapeutic agents used to treat diabetes. We anticipate improved technology that is fully characterized and novel therapeutics that improve microvascular blood flow.Read moreRead less