Targeted Nanoparticle Delivery Of Agents To The Placenta To Treat Preeclampsia
Funder
National Health and Medical Research Council
Funding Amount
$128,224.00
Summary
Preeclampsia, one of the most serious complications of pregnancy, affects around 3-8% of all pregnancies. Sadly, there is no treatment. We have developed a new technique to deliver treatments only to the placenta, sparing the mother and baby from side effects. We will test whether this technique can treat the source of preeclampsia, the placenta, in mouse models and human tissue samples in the laboratory. This work may offer possibilities of new treatments to other pregnancy complications.
Systemic lupus erythematosus (SLE) is a condition which causes inflammation in many different organs and can lead to significant suffering and death. Glucocorticoids (GC) are very good at controlling inflammation, however they have severe side effects such as diabetes and bone thinning, and cannot be used long term. This project aims to investigate a protein “GILZ” in patients with SLE. GILZ may have similar anti-inflammatory effects to GC but may not be associated with the same side effects.
Polypharmacy In The Heart Failure Patient: Are All Prescribed Drug Classes Required?
Funder
National Health and Medical Research Council
Funding Amount
$134,110.00
Summary
This project investigates the issue of polypharmacy is heart failure. Polypharmacy is the use of four or more prescription medications, and heart failure patients take six on average. This project investigates the evidence for safe withdrawal of medications failure that have not been shown to prolong life in heart, doctor and patient attitudes to withdrawing medications, and then runs a series of three clinical trials, each withdrawing a different medication in heart failure patients and closely ....This project investigates the issue of polypharmacy is heart failure. Polypharmacy is the use of four or more prescription medications, and heart failure patients take six on average. This project investigates the evidence for safe withdrawal of medications failure that have not been shown to prolong life in heart, doctor and patient attitudes to withdrawing medications, and then runs a series of three clinical trials, each withdrawing a different medication in heart failure patients and closely monitors the effects.Read moreRead less
The prevalence of liver cirrhosis worldwide is rising due. The majority of the morbidity and mortality, which arises with cirrhosis, occurs due to the development of portal hypertension. In cirrhosis unexplained vasodilatation of the splanchnic circulation occurs contributing significantly to portal hypertension. I expect to confirm through my experiments that the ACE2/Ang 1-7/Mas axis (alternate RAS) is responsible for this vasodilatation and that antagonists targeting this system may have a ro ....The prevalence of liver cirrhosis worldwide is rising due. The majority of the morbidity and mortality, which arises with cirrhosis, occurs due to the development of portal hypertension. In cirrhosis unexplained vasodilatation of the splanchnic circulation occurs contributing significantly to portal hypertension. I expect to confirm through my experiments that the ACE2/Ang 1-7/Mas axis (alternate RAS) is responsible for this vasodilatation and that antagonists targeting this system may have a role in therapy.Read moreRead less
The Role Of Signal Transducer And Activator Of Transcription- (STAT) Related Proteins In Dendritic Cells During Chronic Active Infections
Funder
National Health and Medical Research Council
Funding Amount
$95,313.00
Summary
Chronic infections produced by pathogens such as HIV, overwhelm our immune system leading to an exhausted state where cells responsible for the clearance of invading microorganisms are unable to respond effectively. We have recently identified a highly promising therapeutic target that enhances immune effector function. We seek to understand the underlying mechanism, and to explore its therapeutic potential for use as a common platform to treat diverse infections.