Unravelling The Mechanism Of MHC Class-I Associated Drug Hypersensitivities
Funder
National Health and Medical Research Council
Funding Amount
$566,308.00
Summary
Some drugs cause adverse reactions that are life threatening. We think these reactions are mediated by killer T cells as they are genetically controlled by immune response genes that normally guide immunity to microbes. We will study immune reactions to the drug abacavir, used to treat HIV (AIDS); allopurinol used to prevent gout and carbamazepine, used to treat epilepsy. The study may also help devise better treatments for patients who experience severe forms of these reactions.
DYRK1A As A Novel Target For Glioblastoma Therapies
Funder
National Health and Medical Research Council
Funding Amount
$620,294.00
Summary
Glioblastoma is a form of brain cancer that is currently incurable. We have discovered that switching-off an enzyme called DYRK1A (using ‘DYRK1A inhibitors’) kills glioblastoma cells. This therapeutic advantage is even greater when combined with drugs approved for other cancers. This project will develop new DYRK1A inhibitors and examine a novel combination treatment for glioblastoma patients. This could initiate a novel therapy that could significantly extend patients’ lives.
Establishing advanced networks for air quality sensing and analyses. Establishing advanced networks for air quality sensing and analyses. This project aims to develop innovative, cost-effective, high resolution air quality networks. Recent developments in sensor technologies improve the ability to harvest atmospheric data. This project will develop, validate and implement methods for high sensitivity atmospheric sensing and apply cutting-edge statistical and analytic techniques to the data sets, ....Establishing advanced networks for air quality sensing and analyses. Establishing advanced networks for air quality sensing and analyses. This project aims to develop innovative, cost-effective, high resolution air quality networks. Recent developments in sensor technologies improve the ability to harvest atmospheric data. This project will develop, validate and implement methods for high sensitivity atmospheric sensing and apply cutting-edge statistical and analytic techniques to the data sets, unprecedented in scope and resolution. Outcomes include an open access database to quantify and visualise intra-urban air pollution and human exposure and develop air quality maps and smoke pollution management tools. It is expected to advance the evidence-based management of air as a resource, increasing economic prosperity and enhancing human health and quality of life.Read moreRead less
Preclinical Development Of A Therapeutic Anticancer Antibody To C-Met
Funder
National Health and Medical Research Council
Funding Amount
$435,530.00
Summary
Many common cancers cannot be effectively treated. A range of these cancers (e.g. gastric and lung cancer) display the molecule c-Met on their cell surface. c-Met promotes tumour growth; therefore, blocking c-Met is a promising strategy for treating these cancers. However, no antibodies or drugs that target c-Met have been licensed. The therapeutics that are being developed to target c-Met all have considerable limitations. Thus, there is an opportunity to develop a 'best-in-class' therapeutic.
Airborne ultrafine particles in Australian cities. There is an acute deficiency of knowledge in Australia on urban airborne ultrafine particles, originating from transport and other anthropogenic sources, which pose significant health and environmental risks. The aim of this project is to address this deficiency by an extensive multi-city, cross-disciplinary study using state of the art instrumentation and data analytic techniques. The outcome will be an in depth, quantitative insight into the c ....Airborne ultrafine particles in Australian cities. There is an acute deficiency of knowledge in Australia on urban airborne ultrafine particles, originating from transport and other anthropogenic sources, which pose significant health and environmental risks. The aim of this project is to address this deficiency by an extensive multi-city, cross-disciplinary study using state of the art instrumentation and data analytic techniques. The outcome will be an in depth, quantitative insight into the characteristics of the particles, their sources and spatial and temporal variation across different urban areas and time scales. Further, the impacts of changing fuels, vehicle technologies, and climate on future trends of the particles will be elucidated.Read moreRead less
The Macroderma initiative: conserving ghost bats and informing development. This project aims to improve methods for capturing biological information required for environmental assessments of highly mobile species and enable strategic environmental planning in Northern Australia. Using Australia’s iconic ghost bat as a focus, the project will test and apply emerging technologies to obtain key information on a species’ population status and its critical resources to inform assessments of ecologic ....The Macroderma initiative: conserving ghost bats and informing development. This project aims to improve methods for capturing biological information required for environmental assessments of highly mobile species and enable strategic environmental planning in Northern Australia. Using Australia’s iconic ghost bat as a focus, the project will test and apply emerging technologies to obtain key information on a species’ population status and its critical resources to inform assessments of ecological impacts of industry development. Important benefits of the project include information and tools for streamlining development approvals and accurately assessing risks to threatened species to improve outcomes for both our economy and our natural environment.Read moreRead less
More than a reserve? Measuring the benefits of private protected areas. This project aims to develop a framework for understanding the full suite of benefits derived from privately protected areas in Australia. It will develop and test a new interdisciplinary approach to measure the ecological, socio-cultural, and economic benefits of protected areas to both human and non-human beneficiaries. Outcomes will include a systematic process to effectively gather data, analyse, and report on the full s ....More than a reserve? Measuring the benefits of private protected areas. This project aims to develop a framework for understanding the full suite of benefits derived from privately protected areas in Australia. It will develop and test a new interdisciplinary approach to measure the ecological, socio-cultural, and economic benefits of protected areas to both human and non-human beneficiaries. Outcomes will include a systematic process to effectively gather data, analyse, and report on the full suite of benefits derived from protected areas. The framework will provide a robust evidence base for the range of benefits provided by private protected areas. This will be vital to manage and grow Australia’s protected area network to reduce biodiversity and environmental declines, and meet international commitments.Read moreRead less
Diagnosing river health using invertebrate traits and DNA barcodes. Diagnosing river health using invertebrate traits and DNA barcodes. This project aims to develop indices that link change in invertebrate communities to specific environmental stressors, and combine these indices with innovative, low cost molecular approaches to species identification to rapidly identify the causes of decline. River health assessment methods, usually based on aquatic invertebrates, identify if rivers are impaire ....Diagnosing river health using invertebrate traits and DNA barcodes. Diagnosing river health using invertebrate traits and DNA barcodes. This project aims to develop indices that link change in invertebrate communities to specific environmental stressors, and combine these indices with innovative, low cost molecular approaches to species identification to rapidly identify the causes of decline. River health assessment methods, usually based on aquatic invertebrates, identify if rivers are impaired but must be developed to identify the causes of decline. The intended outcomes are improved sustainable water resource management within and among states, and improved natural resource policy development.Read moreRead less
Taking eDNA underground: transforming assessment of subterranean ecosystems. This project aims to improve Environmental Impact Assessment and monitoring of subterranean ecosystems by developing a rigorous, credible and practicable environmental DNA assessment framework. Resource companies in Western Australia are mandated to assess groundwater biodiversity under Environmental Protection legislation. Current surveys are time-consuming (expensive) and biased toward common taxa. For regulators, sta ....Taking eDNA underground: transforming assessment of subterranean ecosystems. This project aims to improve Environmental Impact Assessment and monitoring of subterranean ecosystems by developing a rigorous, credible and practicable environmental DNA assessment framework. Resource companies in Western Australia are mandated to assess groundwater biodiversity under Environmental Protection legislation. Current surveys are time-consuming (expensive) and biased toward common taxa. For regulators, stakeholders and industry involved in this project we will provide real-world information and cost savings through innovation in understanding patterns in species boundaries and detection of subterranean fauna. The outcomes will be directly applicable to monitoring subterranean ecosystems across Australia and internationally.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100040
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
Integrated Greenhouse Gas Measurement System (IGMS) for monitoring agricultural emissions at field to regional scales. Measurement of greenhouse gases is critical to Australia’s obligations to reduce carbon emissions. The measurement facility will provide urgently needed accurate emission data from Australian agriculture to establish emission baselines and develop methods to extend the point-scale measurements to whole farm, regional and national scales.