SARA: Delineating Its Association With The Onset And Development Of Liver Fibrosis
Funder
National Health and Medical Research Council
Funding Amount
$865,972.00
Summary
Liver disease, a significant burden on society, affects many in the prime of their life. Scarring of the liver is a response to injury due to many factors including alcohol, viruses, obesity, and fatty-liver disease. We have identified a protein associated with liver injury. In this project we will perform a systematic analysis to understand the role of this protein in injury progression. Ultimately we intend to develop tools to prevent and treat liver injury.
The Functional Roles Of ADAMs In The Regulation Of Embryo Implantation.
Funder
National Health and Medical Research Council
Funding Amount
$211,527.00
Summary
The initiation of pregnancy in humans and rodents hinges upon the ability of the embryo to attach to the wall of the uterus and invade into the uterine tissue. This process of embryo implantation is tightly regulated and depends on the secretion of enzymes and regulators of these enzymes. A newly identified family of enzymes which might be important in this process is the ADAMs family. These enzymes have the potential to facilitate both cell attachment and cell invasion and also to activate othe ....The initiation of pregnancy in humans and rodents hinges upon the ability of the embryo to attach to the wall of the uterus and invade into the uterine tissue. This process of embryo implantation is tightly regulated and depends on the secretion of enzymes and regulators of these enzymes. A newly identified family of enzymes which might be important in this process is the ADAMs family. These enzymes have the potential to facilitate both cell attachment and cell invasion and also to activate other enzymes and growth factors. Recent studies in our laboratory have shown the ADAMs to be expressed both at the most invasive time of implantation and when invasion is being down-regulated. This project will examine the role of the ADAMs in embryo implantation facilitating attachment and invasion into the uterus by acting enzymatically on the uterine tissue and by activating other enzymes. It will also determine the role of ADAMs in down-regulating invasion potentially by activating a growth factor, TNF-alpha. Knowledge of this process and particularly its regulation is important for the treatment of pregnancy associated diseases that arise from improper implantation. These include infertility, placenta accreta, choriocarcinoma, miscarriage and pre-eclampsia. Furthermore, an understanding of the regulation of implantation will contribute to the treatment of other conditions associated with cell invasion such as cancer metastasis.Read moreRead less
Enhanced Multilingual Speaker Recognition through the Incorporation of High-Level Features, Late Fusion and Discriminative Classification Methods. The development of robust multilingual speaker recognition systems will benefit the community through the elimination of fraud incurred by financial institutions and customers by enabling several person authentication applications such as: voice based signatures and document issuance; credit card verification by voice and secure over-the-phone financi ....Enhanced Multilingual Speaker Recognition through the Incorporation of High-Level Features, Late Fusion and Discriminative Classification Methods. The development of robust multilingual speaker recognition systems will benefit the community through the elimination of fraud incurred by financial institutions and customers by enabling several person authentication applications such as: voice based signatures and document issuance; credit card verification by voice and secure over-the-phone financial transactions. The technology will also assist in the protection of the community and safeguard Australia by enabling the implementation of the following: suspect identification using voice print; national security measures for combating terrorism by using voice to locate and track terrorists; preemptive criminal activity counter-measures; surveillance and secure building access by voice.Read moreRead less
Robust speaker recognition with reduced utterance duration and intersession variability. The development of robust and accurate speaker recognition systems will enable secure person authentication in over-the-phone financial transactions and benefit the community through the elimination of identity fraud incurred by customers and financial institutions. The technology will also assist in safeguarding Australia by enabling the implementation of suspect identification using voice and security meas ....Robust speaker recognition with reduced utterance duration and intersession variability. The development of robust and accurate speaker recognition systems will enable secure person authentication in over-the-phone financial transactions and benefit the community through the elimination of identity fraud incurred by customers and financial institutions. The technology will also assist in safeguarding Australia by enabling the implementation of suspect identification using voice and security measures for combating terrorism by using voice to locate and track terrorists. Our research at QUT Speech Research Lab is at the forefront of development in this field and will provide Australia with a technological advantage in the rapidly evolving global market for speaker recognition technology for person authentication applications.Read moreRead less
Robust Automatic Speaker Diarisation of Audio Documents by Exploiting Prior Sources of Information. Speaker Diarisation, the task of determining who spoke when, is a technology fundamental in deriving intelligent information from audio and multimedia resources. The requirement for efficient and accurate Speaker Diarisation systems, portable across different domains is heightened by the explosive growth of audio and multimedia archives online and throughout the world. This research will provide t ....Robust Automatic Speaker Diarisation of Audio Documents by Exploiting Prior Sources of Information. Speaker Diarisation, the task of determining who spoke when, is a technology fundamental in deriving intelligent information from audio and multimedia resources. The requirement for efficient and accurate Speaker Diarisation systems, portable across different domains is heightened by the explosive growth of audio and multimedia archives online and throughout the world. This research will provide the foundation for a commercial service of automatic Speaker Diarisation to be developed, growing Australia's impact on the information and communications technology (ICT) sector. The outcome of this research will also assist in the tracking of terrorist and unlawful activity by enabling effective intelligence gathering from different audio sources.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561231
Funder
Australian Research Council
Funding Amount
$671,715.00
Summary
MRI GRID Computing Facility: Design, Optimisation and Image Processing. The MRI Grid Computing Facility provides the IT infrastructure to achieve effective e-research in the area of magnetic resonance (MR) imaging, a field of neuroscience research that revolutionizes the way brain diseases are identified and treated. The facility consists of a dedicated high performance grid compute engine, distributed visualisation workstations, and distributed data warehouse facilities. Software tools acc ....MRI GRID Computing Facility: Design, Optimisation and Image Processing. The MRI Grid Computing Facility provides the IT infrastructure to achieve effective e-research in the area of magnetic resonance (MR) imaging, a field of neuroscience research that revolutionizes the way brain diseases are identified and treated. The facility consists of a dedicated high performance grid compute engine, distributed visualisation workstations, and distributed data warehouse facilities. Software tools accessible through the Internet will enable researchers to archive, retrieve and exchange data and software; access distributed MR image databases and the latest MR image analysis tools; schedule analysis tasks on the grid compute engine, the outcomes of which will be visualized by the visualization workstations.Read moreRead less
Automatic cartilage segmentation in magnetic resonance imaging. Osteoarthritis (OA) is the most common form of arthritis, affecting nearly 1.4 million Australians. This research aims at engineering new tools for use in Magnetic Resonance Imaging systems to enable automated analyses of the cartilage and bones in joint images. The goals of the work are to assist with improved diagnosis and treatment planning for both chronic disease, such as OA, and acute injuries, such as cartilage and ligament ....Automatic cartilage segmentation in magnetic resonance imaging. Osteoarthritis (OA) is the most common form of arthritis, affecting nearly 1.4 million Australians. This research aims at engineering new tools for use in Magnetic Resonance Imaging systems to enable automated analyses of the cartilage and bones in joint images. The goals of the work are to assist with improved diagnosis and treatment planning for both chronic disease, such as OA, and acute injuries, such as cartilage and ligament tears in sporting injuries and other traumas.
The software developed will be provided on the project’s partner (Siemens) platform and will therefore be available worldwide and have a consequently large impact on the field.
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Techniques to use stereo vision for improving person identification systems based on face recognition. The broad aim of this project is to use three-dimensional information available by processing images from stereo cameras in order to bridge the gap between constrained face recognition systems and viable systems that work well under varying illumination, changes in pose and variations in spectacles, facial hair and attire. Such a system will be useful in passenger verification at airports and a ....Techniques to use stereo vision for improving person identification systems based on face recognition. The broad aim of this project is to use three-dimensional information available by processing images from stereo cameras in order to bridge the gap between constrained face recognition systems and viable systems that work well under varying illumination, changes in pose and variations in spectacles, facial hair and attire. Such a system will be useful in passenger verification at airports and as a component of personal identification systems to counter terrorism. The key to successful face location and recognition is an effective combination of all data - range, luminance and colour - and techniques for this will be the discovered outcomes.Read moreRead less
The next generation speaker recognition system. The next generation of speaker recognition technologies developed through this project will enable secure person authentication by voice in financial transactions and benefit the community through the elimination of identity fraud. This project will safeguard Australia by identifying criminal suspects using their voice and combat terrorism by using voice to locate and track terrorists.
Progressive Transmission of Street Directory Assistance and Business Pages over 3G and 4G mobile networks. Multimedia on-demand and live services over 3G and 4G mobiles will be enhanced. New methods for low volume, high information transfer multimedia transactions will be developed. This will create new jobs in the Information and Communication Technologies (ICT) sector. Progressive transmission of street directory assistance and business pages information to mobile handsets will enable citize ....Progressive Transmission of Street Directory Assistance and Business Pages over 3G and 4G mobile networks. Multimedia on-demand and live services over 3G and 4G mobiles will be enhanced. New methods for low volume, high information transfer multimedia transactions will be developed. This will create new jobs in the Information and Communication Technologies (ICT) sector. Progressive transmission of street directory assistance and business pages information to mobile handsets will enable citizens to make efficient use of their time and improve productivity. The 3G and 4G cellular telephone network, extended with 'mobile' base stations and satellite links, are especially attractive to a large country like Australia. Interactive information retrieval will become more universal and not limited through wired Internet connections.
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