The Functional Roles Of ADAMs In The Regulation Of Embryo Implantation.
Funder
National Health and Medical Research Council
Funding Amount
$211,527.00
Summary
The initiation of pregnancy in humans and rodents hinges upon the ability of the embryo to attach to the wall of the uterus and invade into the uterine tissue. This process of embryo implantation is tightly regulated and depends on the secretion of enzymes and regulators of these enzymes. A newly identified family of enzymes which might be important in this process is the ADAMs family. These enzymes have the potential to facilitate both cell attachment and cell invasion and also to activate othe ....The initiation of pregnancy in humans and rodents hinges upon the ability of the embryo to attach to the wall of the uterus and invade into the uterine tissue. This process of embryo implantation is tightly regulated and depends on the secretion of enzymes and regulators of these enzymes. A newly identified family of enzymes which might be important in this process is the ADAMs family. These enzymes have the potential to facilitate both cell attachment and cell invasion and also to activate other enzymes and growth factors. Recent studies in our laboratory have shown the ADAMs to be expressed both at the most invasive time of implantation and when invasion is being down-regulated. This project will examine the role of the ADAMs in embryo implantation facilitating attachment and invasion into the uterus by acting enzymatically on the uterine tissue and by activating other enzymes. It will also determine the role of ADAMs in down-regulating invasion potentially by activating a growth factor, TNF-alpha. Knowledge of this process and particularly its regulation is important for the treatment of pregnancy associated diseases that arise from improper implantation. These include infertility, placenta accreta, choriocarcinoma, miscarriage and pre-eclampsia. Furthermore, an understanding of the regulation of implantation will contribute to the treatment of other conditions associated with cell invasion such as cancer metastasis.Read moreRead less
Alpha-2-Macroglobulin And The Transport And Uptake Of The Hormone, Hepcidin
Funder
National Health and Medical Research Council
Funding Amount
$533,541.00
Summary
Hepcidin is a peptide hormone that is a major regulator of iron metabolism. It has been suggested that hepcidin is free in the blood. However, we recently identified that hepcidin binds with alpha-2-macroglobulin (a2-M) in the plasma and this increases the efficacy of this peptide. The demonstration that a2-M plays a role in hepcidin biology will lead to a better understanding of hepcidin physiology, the development of methods for its measurement and improved treatment of iron related diseases.
A scalable and portable question-answering system. The current availability of large volumes of free text digitally stored demands the development of methodologies that can automatically find specific answers to user questions about this "unstructured" information. The goal of this project is to develop a scalable portable and domain-independent real-time natural-language question-answering system that explores the logical contents of the text. To achieve this we will fuse current approaches to ....A scalable and portable question-answering system. The current availability of large volumes of free text digitally stored demands the development of methodologies that can automatically find specific answers to user questions about this "unstructured" information. The goal of this project is to develop a scalable portable and domain-independent real-time natural-language question-answering system that explores the logical contents of the text. To achieve this we will fuse current approaches to question answering with approaches that look at the logical contents of the questions and answer candidates. A central part of the project will be the characterisation of the optimal logical forms, the determination of efficient methods to create and store sentence logical forms of potentially large volumes of text, and the treatment of difficult questions by incorporating summarisation and text generation techniques.Read moreRead less
A Layered Controlled Natural Language for Knowledge Representation. In this research project we will develop a controlled natural language for knowledge representation that has the potential to bridge the gap between fragments of natural language and formal languages. This controlled language will be based on a variety of increasing sophisticated layers, each building upon those below it by providing enhancements in expressive power. Sentences of the controlled language will be unambiguously tra ....A Layered Controlled Natural Language for Knowledge Representation. In this research project we will develop a controlled natural language for knowledge representation that has the potential to bridge the gap between fragments of natural language and formal languages. This controlled language will be based on a variety of increasing sophisticated layers, each building upon those below it by providing enhancements in expressive power. Sentences of the controlled language will be unambiguously translatable into a corresponding formal language. Anyone who can read and write English can immediately use the controlled language with the help an intelligent text editor. This technology will make it possible for non-specialists to write problem specifications in terms of the application domain without the need to formally encode the information.Read moreRead less
A Skin Detection Micro-Sensor for Face Identification using Color and Stereo Information. The objective of this research is to develop a micro-sensor for face identification, using color and stereo information. The micro-sensor chip performs a real-time search of the scene to locate human skin for subsequent face detection. This micro-sensor could also be used for gesture recognition, lip reading, monitoring driver's hypo-vigilance or tracking a person in a crowd. The chip image-recognition capa ....A Skin Detection Micro-Sensor for Face Identification using Color and Stereo Information. The objective of this research is to develop a micro-sensor for face identification, using color and stereo information. The micro-sensor chip performs a real-time search of the scene to locate human skin for subsequent face detection. This micro-sensor could also be used for gesture recognition, lip reading, monitoring driver's hypo-vigilance or tracking a person in a crowd. The chip image-recognition capabilities will spur the development of a new generation of consumer products with "intelligent eyes".
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100235
Funder
Australian Research Council
Funding Amount
$280,000.00
Summary
Accelerating Australia's large scale video surveillance research programmes. The research to be conducted using this infrastructure will bring immense benefits to Australia in terms of increased levels of public safety and in the protection of critical facilities from terrorism and other crimes, by developing better surveillance systems. This will provide both increases in measurable research outputs and opportunities for Australian business to commercialise these systems. The infrastructure wil ....Accelerating Australia's large scale video surveillance research programmes. The research to be conducted using this infrastructure will bring immense benefits to Australia in terms of increased levels of public safety and in the protection of critical facilities from terrorism and other crimes, by developing better surveillance systems. This will provide both increases in measurable research outputs and opportunities for Australian business to commercialise these systems. The infrastructure will accelerate the pace of surveillance research and development in Australia, enhancing the competitiveness of both Australia's researchers and the businesses that will commercialise these researchers' discoveries.Read moreRead less
A Computer-Aided Cartooning System. This project is aimed at developing a computer-aided system to accelerate main image-related processes in cartoon production. Using such a system, many of the tedious and repetitive tasks can be performed semi-automatically. The project is focused on accurate representation and matching of shapes. New vectorization methods based on projection onto convex sets (POCS), and new matching methods based on multi-stage hierarchical structures will be developed. The t ....A Computer-Aided Cartooning System. This project is aimed at developing a computer-aided system to accelerate main image-related processes in cartoon production. Using such a system, many of the tedious and repetitive tasks can be performed semi-automatically. The project is focused on accurate representation and matching of shapes. New vectorization methods based on projection onto convex sets (POCS), and new matching methods based on multi-stage hierarchical structures will be developed. The targeted applications include entertainment, next generation mobile services, and the internet.Read moreRead less
Vision Model Based Perceptual Digital Video Coding. Digital video coding and compression is an enabling technology and has diversified applications in audiovisual communications, multimedia computing, digital television broadcast and electronic entertainment industries. The project aims at spearheading research in theory, techniques and implementation of perceptual video coding in order to achieve constant and guaranteed quality in visual communications and services. It will explore a new appr ....Vision Model Based Perceptual Digital Video Coding. Digital video coding and compression is an enabling technology and has diversified applications in audiovisual communications, multimedia computing, digital television broadcast and electronic entertainment industries. The project aims at spearheading research in theory, techniques and implementation of perceptual video coding in order to achieve constant and guaranteed quality in visual communications and services. It will explore a new approach to digital video coding other than the constant bit rate coding techniques which have dominated digital video research for the past four decades. It will form a part of the theoretical foundation and principles for the next generation video coding and compression techniques, and may lead to new standards and practice.Read moreRead less
Advanced Processing for Through-the-Wall Radar Imaging. There is currently considerable interest around the world in imaging systems that can 'see' through-the-walls. This project is at the cutting edge of through-the-wall radar imaging research and technology. It will benefit both the defence and security industries, and position Australia among the leading countries in this technology, as only a handful of research teams around the world have the necessary background and expertise in this area ....Advanced Processing for Through-the-Wall Radar Imaging. There is currently considerable interest around the world in imaging systems that can 'see' through-the-walls. This project is at the cutting edge of through-the-wall radar imaging research and technology. It will benefit both the defence and security industries, and position Australia among the leading countries in this technology, as only a handful of research teams around the world have the necessary background and expertise in this area. The research outcomes will enhance the capability of the military, law enforcement, counter-terrorism, and search and rescue personnel. It will play a vital role in protecting and safeguarding Australia from terrorism and crime.Read moreRead less
Enhanced Through-Wall Imaging using Bayesian Compressive Sensing. The aim of this project is to develop radar imaging techniques which enable us to 'see' objects behind walls and opaque materials. The major intended breakthrough is the ability to image objects behind walls and inside buildings or enclosed structures without accessing the scene. Novel signal and image processing algorithms, based on Bayesian compressive sensing, will be developed to enhance image quality and resolution, improve s ....Enhanced Through-Wall Imaging using Bayesian Compressive Sensing. The aim of this project is to develop radar imaging techniques which enable us to 'see' objects behind walls and opaque materials. The major intended breakthrough is the ability to image objects behind walls and inside buildings or enclosed structures without accessing the scene. Novel signal and image processing algorithms, based on Bayesian compressive sensing, will be developed to enhance image quality and resolution, improve speed of operation, and reduce the cost and time of data acquisition and processing. Many applications are expected to benefit from this research including search and rescue, surveillance, security, and defence. The research outcomes are expected to enhance the capabilities of the Australian armed forces, counter-terrorism, police and law-enforcement agencies.Read moreRead less