Understanding Neuroinflammation In Alzheimer's Disease
Funder
National Health and Medical Research Council
Funding Amount
$1,043,216.00
Summary
This project opens a new line of enquiry into the cellular signalling mechanisms involved in the progression of AD and establishes whether targeting the involvement of type-1 IFN signalling influences the evolution of AD. New and novel approaches are clearly required to treat AD. Importantly, we believe that neuroinflammation is common to all causes of dementia and targeting the neuroinflammatory pathways has much wider implications than targeting the primary causative pathway.
Controlling Neuroinflammation In Alzheimer's Disease
Funder
National Health and Medical Research Council
Summary
Alzheimer’s disease (AD) is the most common neurodegenerative disorder worldwide, with 269,000 Australians currently diagnosed with AD and is expected to soar to about 981,000 by 2050. AD accounts for greater than 60% of all cases of dementia. This grant investigates the role that neuroinflammation plays in the progression and exacerbation of AD and will identify new therapeutic strategies to combat this insidious disease.
Testing The Prion Hypothesis In Parkinson’s Disease Using A Novel In Vivo Model Of Α-synuclein Transmission
Funder
National Health and Medical Research Council
Funding Amount
$622,555.00
Summary
Parkinson’s Disease (PD) is a debilitating neurological disease with no cure. Recently it has been discovered that the disease can spread through the brain. We have developed the worlds first animal model to study exactly how the disease propagates inside of neurons during this spread. We will use the model to answer key questions about this critical stage of disease spread, knowledge that is essential for the development of successful therapies to prevent disease progression.
Information Delivery from Segmented Textual Data Streams. This project will contribute to the advancement of ICT innovation in Australia by developing a robust, reusable language understanding engine. The technology will be tailored to web applications, in the form of a conceptually-aware web search engine capable of tracking cross-document dialogues and identifying the core semantic thread of the dialogue. It will place Australia at the forefront of next-generation language technology developme ....Information Delivery from Segmented Textual Data Streams. This project will contribute to the advancement of ICT innovation in Australia by developing a robust, reusable language understanding engine. The technology will be tailored to web applications, in the form of a conceptually-aware web search engine capable of tracking cross-document dialogues and identifying the core semantic thread of the dialogue. It will place Australia at the forefront of next-generation language technology development, with applications in areas including concept-based multi-document summarisation and email surveillance.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561231
Funder
Australian Research Council
Funding Amount
$671,715.00
Summary
MRI GRID Computing Facility: Design, Optimisation and Image Processing. The MRI Grid Computing Facility provides the IT infrastructure to achieve effective e-research in the area of magnetic resonance (MR) imaging, a field of neuroscience research that revolutionizes the way brain diseases are identified and treated. The facility consists of a dedicated high performance grid compute engine, distributed visualisation workstations, and distributed data warehouse facilities. Software tools acc ....MRI GRID Computing Facility: Design, Optimisation and Image Processing. The MRI Grid Computing Facility provides the IT infrastructure to achieve effective e-research in the area of magnetic resonance (MR) imaging, a field of neuroscience research that revolutionizes the way brain diseases are identified and treated. The facility consists of a dedicated high performance grid compute engine, distributed visualisation workstations, and distributed data warehouse facilities. Software tools accessible through the Internet will enable researchers to archive, retrieve and exchange data and software; access distributed MR image databases and the latest MR image analysis tools; schedule analysis tasks on the grid compute engine, the outcomes of which will be visualized by the visualization workstations.Read moreRead less
eResearch in the Neurosciences: Building collaborations in Asia. The proposed Australasian collaboration on eResearch in Neuroscience will promote and maintain the good health of Australians by 'improving critical mass through collaboration and information sharing' through increased access to advanced imaging technology in Korea and analysis techniques in Japan. The collaboration will also promote frontier technologies for building and transforming Australian industries by developing a creative ....eResearch in the Neurosciences: Building collaborations in Asia. The proposed Australasian collaboration on eResearch in Neuroscience will promote and maintain the good health of Australians by 'improving critical mass through collaboration and information sharing' through increased access to advanced imaging technology in Korea and analysis techniques in Japan. The collaboration will also promote frontier technologies for building and transforming Australian industries by developing a creative and innovative research environment and enhancing Australian scientists' participation in breakthrough science. Great national benefit can be derived from international research collaboration, due to the contribution frontier technology can make to science and health. Read moreRead less
Fairness in Natural Language Processing. Natural language processing (NLP) has achieved spectacular commercial successes in recent years, and has been deployed across an ever-increasing breadth of devices and application areas. At the same time, there has been stark evidence to indicate that naively-trained models amplify biases in training data, and perform inconsistently across text relating to different demographic groupings of individuals. This project aims to systematically quantify the ext ....Fairness in Natural Language Processing. Natural language processing (NLP) has achieved spectacular commercial successes in recent years, and has been deployed across an ever-increasing breadth of devices and application areas. At the same time, there has been stark evidence to indicate that naively-trained models amplify biases in training data, and perform inconsistently across text relating to different demographic groupings of individuals. This project aims to systematically quantify the extent of such biases, and develop models that are both more socially equitable, as well as less prone to expose private data in the learned representations. In doing so, it will make NLP more accessible to new populations of users, and remove socio-technological barriers to NLP uptake.Read moreRead less
Discovering justified knowledge from data. Knowledge discovery from data has assumed a critical role in numerous areas of science, commerce and public administration. However, its effectiveness is limited by the undesirable propensity of current techniques to make many false, as well as real, discoveries. This research will rectify that problem, a critical outcome given the potential cost of making decisions or setting policy using flawed information. For example, it may prevent the adoption of ....Discovering justified knowledge from data. Knowledge discovery from data has assumed a critical role in numerous areas of science, commerce and public administration. However, its effectiveness is limited by the undesirable propensity of current techniques to make many false, as well as real, discoveries. This research will rectify that problem, a critical outcome given the potential cost of making decisions or setting policy using flawed information. For example, it may prevent the adoption of ineffective strategies for addressing land degradation; inappropriately targeted public health expenditure; expensive development and clinical trialing of drugs which prove ineffective; and wasted police and security investigations into unfounded suspicions of criminal or terrorist activity.Read moreRead less
Modelling and Removal of Noise and Artefacts in Surveillance and Security Video for Forensic Image Analysis and Enhancement. This project spearheads research in advanced digital image and video processing technology, placing Australia at the forefront of both theoretical and applied research to safeguard Australia. It tackles fundamental issues identified in our earlier research in this area and consulting work for Victoria and NSW Police Departments in forensic investigations since 2000. Althou ....Modelling and Removal of Noise and Artefacts in Surveillance and Security Video for Forensic Image Analysis and Enhancement. This project spearheads research in advanced digital image and video processing technology, placing Australia at the forefront of both theoretical and applied research to safeguard Australia. It tackles fundamental issues identified in our earlier research in this area and consulting work for Victoria and NSW Police Departments in forensic investigations since 2000. Although the main investigation focuses on video surveillance and security systems for public safety, policing, crime prevention and border control, the outcomes of the investigation will have other applications, including digital photography for fine-art, medical imaging, picture archiving and communication systems for telemedicine and rural healthcare systems.Read moreRead less
Multi-Modal Dictionary Learning for Smart City Operation and Management. This Project aims to provide new digital asset management tools for city councils to improve city services by utilising new sensing and automated learning technologies for recognising, tracking and auditing of assets. Currently, there are no digital tools available to handle these services. This project proposes new multi-modal sensing and mapping of city asset techniques by building new multi-modal dictionary learning proc ....Multi-Modal Dictionary Learning for Smart City Operation and Management. This Project aims to provide new digital asset management tools for city councils to improve city services by utilising new sensing and automated learning technologies for recognising, tracking and auditing of assets. Currently, there are no digital tools available to handle these services. This project proposes new multi-modal sensing and mapping of city asset techniques by building new multi-modal dictionary learning procedures. The new framework will recognise different conditions of city assets in real-time to make decisions. Expected outcomes of this Project include integration and easy access of assets with unique digital identities to help city councils, governments, and navigation services for real-time asset monitoring.Read moreRead less