The Effect Of Stress And Hypercortisolaemia On Limbic Epileptogenesis & Affective Disorder.
Funder
National Health and Medical Research Council
Funding Amount
$380,714.00
Summary
This project has the potential to provide novel insights about the causal connections between stress, psychiatric illness (specifically anxiety and depression) and temporal lobe epilepsy (TLE) - the most common form of medical refractory epilepsy in the community. Up to 50% of patients with TLE suffer from anxiety and-or depression. Until relatively recently it had been widely assumed that this was a consequence of the chronic epileptic condition. However, recent evidence suggests that there is ....This project has the potential to provide novel insights about the causal connections between stress, psychiatric illness (specifically anxiety and depression) and temporal lobe epilepsy (TLE) - the most common form of medical refractory epilepsy in the community. Up to 50% of patients with TLE suffer from anxiety and-or depression. Until relatively recently it had been widely assumed that this was a consequence of the chronic epileptic condition. However, recent evidence suggests that there is a bi-directional relationship, with the psychiatric conditions and stress also acting to aggravate the seizures and even predispose to the development of the epilepsy itself. Apart from gaining insights into causes of TLE, anxiety and depression, this framework has potential public health relevance suggesting approaches to the eventual primary and secondary prevention of both MTLE and its associated psychiatric co-morbidities, a neglected area at present. The use of an animal model allows investigation of aetiological processes that extend over the lifetime, which is exceptionally difficult to achieve in humans. Retrospective studies, such as case-control studies, although an indispensable research methods, are subject to bias and imprecision when it comes to measuring remote past exposures to stress, abuse, and deprivation. If the results of these experiments are consistent with our hypotheses, a very strong case would exist for exploring this relationship in human studies. The data would also provide a strong rationale for more aggressive detection and treatment of these psychiatric co-morbidities in TLE patients, in order to potentially modify the progression of the disorder as well as improve the quality of life of sufferers. The results of intervention studies in animal models may suggest specific mode of treatment to achieve this.Read moreRead less
Why Does Early Life Stress Aggravate Limbic Epileptogenesis?
Funder
National Health and Medical Research Council
Funding Amount
$540,116.00
Summary
High rates of anxiety and depression occur in individuals with temporal lobe epilepsy (TLE), the most common form of focal epilepsy in adults. Rats that have experienced early life stress show increased anxiety, decreased seizure thresholds and accelerated epilepsy as adults. We have important leads to mechanisms. The proposed study will better understand the mechanisms connecting early life stress and psychiatric disease to adult TLE, and to test interventions that may counteract these effects.
Information Delivery from Segmented Textual Data Streams. This project will contribute to the advancement of ICT innovation in Australia by developing a robust, reusable language understanding engine. The technology will be tailored to web applications, in the form of a conceptually-aware web search engine capable of tracking cross-document dialogues and identifying the core semantic thread of the dialogue. It will place Australia at the forefront of next-generation language technology developme ....Information Delivery from Segmented Textual Data Streams. This project will contribute to the advancement of ICT innovation in Australia by developing a robust, reusable language understanding engine. The technology will be tailored to web applications, in the form of a conceptually-aware web search engine capable of tracking cross-document dialogues and identifying the core semantic thread of the dialogue. It will place Australia at the forefront of next-generation language technology development, with applications in areas including concept-based multi-document summarisation and email surveillance.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561231
Funder
Australian Research Council
Funding Amount
$671,715.00
Summary
MRI GRID Computing Facility: Design, Optimisation and Image Processing. The MRI Grid Computing Facility provides the IT infrastructure to achieve effective e-research in the area of magnetic resonance (MR) imaging, a field of neuroscience research that revolutionizes the way brain diseases are identified and treated. The facility consists of a dedicated high performance grid compute engine, distributed visualisation workstations, and distributed data warehouse facilities. Software tools acc ....MRI GRID Computing Facility: Design, Optimisation and Image Processing. The MRI Grid Computing Facility provides the IT infrastructure to achieve effective e-research in the area of magnetic resonance (MR) imaging, a field of neuroscience research that revolutionizes the way brain diseases are identified and treated. The facility consists of a dedicated high performance grid compute engine, distributed visualisation workstations, and distributed data warehouse facilities. Software tools accessible through the Internet will enable researchers to archive, retrieve and exchange data and software; access distributed MR image databases and the latest MR image analysis tools; schedule analysis tasks on the grid compute engine, the outcomes of which will be visualized by the visualization workstations.Read moreRead less
eResearch in the Neurosciences: Building collaborations in Asia. The proposed Australasian collaboration on eResearch in Neuroscience will promote and maintain the good health of Australians by 'improving critical mass through collaboration and information sharing' through increased access to advanced imaging technology in Korea and analysis techniques in Japan. The collaboration will also promote frontier technologies for building and transforming Australian industries by developing a creative ....eResearch in the Neurosciences: Building collaborations in Asia. The proposed Australasian collaboration on eResearch in Neuroscience will promote and maintain the good health of Australians by 'improving critical mass through collaboration and information sharing' through increased access to advanced imaging technology in Korea and analysis techniques in Japan. The collaboration will also promote frontier technologies for building and transforming Australian industries by developing a creative and innovative research environment and enhancing Australian scientists' participation in breakthrough science. Great national benefit can be derived from international research collaboration, due to the contribution frontier technology can make to science and health. Read moreRead less
Fairness in Natural Language Processing. Natural language processing (NLP) has achieved spectacular commercial successes in recent years, and has been deployed across an ever-increasing breadth of devices and application areas. At the same time, there has been stark evidence to indicate that naively-trained models amplify biases in training data, and perform inconsistently across text relating to different demographic groupings of individuals. This project aims to systematically quantify the ext ....Fairness in Natural Language Processing. Natural language processing (NLP) has achieved spectacular commercial successes in recent years, and has been deployed across an ever-increasing breadth of devices and application areas. At the same time, there has been stark evidence to indicate that naively-trained models amplify biases in training data, and perform inconsistently across text relating to different demographic groupings of individuals. This project aims to systematically quantify the extent of such biases, and develop models that are both more socially equitable, as well as less prone to expose private data in the learned representations. In doing so, it will make NLP more accessible to new populations of users, and remove socio-technological barriers to NLP uptake.Read moreRead less
Discovering justified knowledge from data. Knowledge discovery from data has assumed a critical role in numerous areas of science, commerce and public administration. However, its effectiveness is limited by the undesirable propensity of current techniques to make many false, as well as real, discoveries. This research will rectify that problem, a critical outcome given the potential cost of making decisions or setting policy using flawed information. For example, it may prevent the adoption of ....Discovering justified knowledge from data. Knowledge discovery from data has assumed a critical role in numerous areas of science, commerce and public administration. However, its effectiveness is limited by the undesirable propensity of current techniques to make many false, as well as real, discoveries. This research will rectify that problem, a critical outcome given the potential cost of making decisions or setting policy using flawed information. For example, it may prevent the adoption of ineffective strategies for addressing land degradation; inappropriately targeted public health expenditure; expensive development and clinical trialing of drugs which prove ineffective; and wasted police and security investigations into unfounded suspicions of criminal or terrorist activity.Read moreRead less
Modelling and Removal of Noise and Artefacts in Surveillance and Security Video for Forensic Image Analysis and Enhancement. This project spearheads research in advanced digital image and video processing technology, placing Australia at the forefront of both theoretical and applied research to safeguard Australia. It tackles fundamental issues identified in our earlier research in this area and consulting work for Victoria and NSW Police Departments in forensic investigations since 2000. Althou ....Modelling and Removal of Noise and Artefacts in Surveillance and Security Video for Forensic Image Analysis and Enhancement. This project spearheads research in advanced digital image and video processing technology, placing Australia at the forefront of both theoretical and applied research to safeguard Australia. It tackles fundamental issues identified in our earlier research in this area and consulting work for Victoria and NSW Police Departments in forensic investigations since 2000. Although the main investigation focuses on video surveillance and security systems for public safety, policing, crime prevention and border control, the outcomes of the investigation will have other applications, including digital photography for fine-art, medical imaging, picture archiving and communication systems for telemedicine and rural healthcare systems.Read moreRead less
Multi-Modal Dictionary Learning for Smart City Operation and Management. This Project aims to provide new digital asset management tools for city councils to improve city services by utilising new sensing and automated learning technologies for recognising, tracking and auditing of assets. Currently, there are no digital tools available to handle these services. This project proposes new multi-modal sensing and mapping of city asset techniques by building new multi-modal dictionary learning proc ....Multi-Modal Dictionary Learning for Smart City Operation and Management. This Project aims to provide new digital asset management tools for city councils to improve city services by utilising new sensing and automated learning technologies for recognising, tracking and auditing of assets. Currently, there are no digital tools available to handle these services. This project proposes new multi-modal sensing and mapping of city asset techniques by building new multi-modal dictionary learning procedures. The new framework will recognise different conditions of city assets in real-time to make decisions. Expected outcomes of this Project include integration and easy access of assets with unique digital identities to help city councils, governments, and navigation services for real-time asset monitoring.Read moreRead less
Vision Model Based Perceptual Digital Video Coding. Digital video coding and compression is an enabling technology and has diversified applications in audiovisual communications, multimedia computing, digital television broadcast and electronic entertainment industries. The project aims at spearheading research in theory, techniques and implementation of perceptual video coding in order to achieve constant and guaranteed quality in visual communications and services. It will explore a new appr ....Vision Model Based Perceptual Digital Video Coding. Digital video coding and compression is an enabling technology and has diversified applications in audiovisual communications, multimedia computing, digital television broadcast and electronic entertainment industries. The project aims at spearheading research in theory, techniques and implementation of perceptual video coding in order to achieve constant and guaranteed quality in visual communications and services. It will explore a new approach to digital video coding other than the constant bit rate coding techniques which have dominated digital video research for the past four decades. It will form a part of the theoretical foundation and principles for the next generation video coding and compression techniques, and may lead to new standards and practice.Read moreRead less