Unraveling the geology of Mars. This project aims to use a suite of innovative conceptual and technical tools that target specific weaknesses in existing Mars exploration programs – where comparatively modest investment could deliver transformative change in one of the largest global research efforts, on which current expenditure is in billions of dollars. The project expects to provide context for the geologic processes that affected Mars. Expected outcomes include a better understanding of the ....Unraveling the geology of Mars. This project aims to use a suite of innovative conceptual and technical tools that target specific weaknesses in existing Mars exploration programs – where comparatively modest investment could deliver transformative change in one of the largest global research efforts, on which current expenditure is in billions of dollars. The project expects to provide context for the geologic processes that affected Mars. Expected outcomes include a better understanding of the habitability and geological history of Mars as well as facilitating both future mission landing site selection and providing context for comparison to the early history of Earth.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100067
Funder
Australian Research Council
Funding Amount
$390,000.00
Summary
The Vevo 2100 Micro-ultrasound plus LAZR Photoacoustic Imaging Platform . The Vevo 2100 micro-ultrasound plus LAZR photoacoustic imaging platform: The Vevo/LAZR ultrasound/photoacoustic imaging facility will allow researchers to achieve multiple outcomes: to visualise and quantify, non-invasively, tissue and molecular structures; the movement and behaviour of cells; and the delivery patterns of administered imaging dyes and nanoparticles in mouse models and reconstructed tissues. This will enabl ....The Vevo 2100 Micro-ultrasound plus LAZR Photoacoustic Imaging Platform . The Vevo 2100 micro-ultrasound plus LAZR photoacoustic imaging platform: The Vevo/LAZR ultrasound/photoacoustic imaging facility will allow researchers to achieve multiple outcomes: to visualise and quantify, non-invasively, tissue and molecular structures; the movement and behaviour of cells; and the delivery patterns of administered imaging dyes and nanoparticles in mouse models and reconstructed tissues. This will enable researchers to obtain anatomical, functional, physiological and molecular data simultaneously and in real-time, with resolution down to 40 micrometres. This will translate into both user efficiency and laboratory cost effectiveness, but more significantly is expected to result in greater understanding of fundamental mechanisms regulating the body's cell and tissue functions.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100488
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Cellular dynamics of nanoengineered particles. Nanotechnology has the capacity to drive a new wave of biological innovation through engineering materials at the nanoscale. This project will advance understanding of how nanoengineered materials interact with biological systems to enable the development of nanomaterials for future translational research.
Human-Machine Teaming:Designing synergistic learning of humans and machines. This proposal investigates the design of systems in which humans and machines use their different abilities to learn together for mutual benefit. Machine learning has been commoditised, applied in areas such as medical image reading and autonomous vehicles, however it typically operates separately from humans, supplanting human skills and leading to deskilling. Using human-computer interaction research techniques, co-de ....Human-Machine Teaming:Designing synergistic learning of humans and machines. This proposal investigates the design of systems in which humans and machines use their different abilities to learn together for mutual benefit. Machine learning has been commoditised, applied in areas such as medical image reading and autonomous vehicles, however it typically operates separately from humans, supplanting human skills and leading to deskilling. Using human-computer interaction research techniques, co-design and iterative prototyping in the domains of radiology training and environmental learning, we will devise and evaluate exemplar systems that support humans to interactively frame problems, explore and learn, while utilising and improving machine models, leading to a guiding framework for designing human-machine teaming.Read moreRead less
Uncovering the Chronology of Mars. This project aims to answer fundamental questions about the origin and evolution of the solar system by utilizing innovative machine learning techniques developed by our group. Starting with Mars, we will interrogate the highest resolution image data to automatically generate the ultimate resolution global age map. The expected outcomes of this project include determining the absolute ages of geologic processes on Mars to deliver a groundbreaking look at the ge ....Uncovering the Chronology of Mars. This project aims to answer fundamental questions about the origin and evolution of the solar system by utilizing innovative machine learning techniques developed by our group. Starting with Mars, we will interrogate the highest resolution image data to automatically generate the ultimate resolution global age map. The expected outcomes of this project include determining the absolute ages of geologic processes on Mars to deliver a groundbreaking look at the geology of another planet at the centimeter scale. A major benefit of this project will be enhancing Australia’s role as a leader in space and planetary science through this interdisciplinary, international collaboration across engineering, geology, computing, and chronology.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150101518
Funder
Australian Research Council
Funding Amount
$345,000.00
Summary
Cellular responses to nanoparticles from cells on micropatterned surfaces. The mechanisms underlying cell-nanoparticle interactions remain largely unknown. It has hampered the design and development of innovative nano devices to be used for drug delivery, biomarkers and diagnostics. This project aims to explore the influences of cell size, density, geometry, intercellular communication and substrate properties on cell-nanoparticle interactions. A micropatterning technology is applied to precisel ....Cellular responses to nanoparticles from cells on micropatterned surfaces. The mechanisms underlying cell-nanoparticle interactions remain largely unknown. It has hampered the design and development of innovative nano devices to be used for drug delivery, biomarkers and diagnostics. This project aims to explore the influences of cell size, density, geometry, intercellular communication and substrate properties on cell-nanoparticle interactions. A micropatterning technology is applied to precisely control cell behaviour and provide a novel in vitro cellular model for nanoparticle studies. This project aims to significantly improve the understanding of cell-nanoparticle interactions to provide new insight into nanoparticle design and improve the efficacy of nano devices.Read moreRead less
Decoding the chronology of Mars. This project aims to determine a detailed and accurate geologic timescale for Mars, using image processing, high performance computing, geochemistry and geochronology. Mars is the nearest possibly habitable planet to our own. The project will apply automated feature recognition techniques to high resolution space-craft derived images of the surface of Mars and study formation ages of Martian meteorites. The goal is an absolute chronology for Mars. This contribute ....Decoding the chronology of Mars. This project aims to determine a detailed and accurate geologic timescale for Mars, using image processing, high performance computing, geochemistry and geochronology. Mars is the nearest possibly habitable planet to our own. The project will apply automated feature recognition techniques to high resolution space-craft derived images of the surface of Mars and study formation ages of Martian meteorites. The goal is an absolute chronology for Mars. This contributes to a better understanding of the geologic and habitability history of Mars, facilitating both future mission landing site selection and providing context for comparison to the early history of Earth.Read moreRead less
Augmented Sociality: Enabling a Socialised Experience of Augmented Reality. This project will explore new socialised uses of Augmented Reality (AR) that expand creativity, social relations, and participation. We seek to better understand how AR content can be leveraged by people to create their own new ways of learning, collaborating, and relating with each other. To do so we will study and prototype new tools and platforms to allow non-experts to create their own AR media. We aim to enable peop ....Augmented Sociality: Enabling a Socialised Experience of Augmented Reality. This project will explore new socialised uses of Augmented Reality (AR) that expand creativity, social relations, and participation. We seek to better understand how AR content can be leveraged by people to create their own new ways of learning, collaborating, and relating with each other. To do so we will study and prototype new tools and platforms to allow non-experts to create their own AR media. We aim to enable people of all ages, education, and background, to imagine and create, and not just passively consume, AR contents, services, and applications. We will generate new applications of AR, a new platform to collaboratively create these applications, and a new theory of 'Augmented Sociality' to guide AR design.
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Multifunctional and Multimodal Theranostics: Manipulating Material Properties for Advanced Diagnostics. The utilisation of polymers in nanomedicine requires a bottom-up approach, where the fundamental chemistry is well-established and understood before it enables an application. This project develops branched polymers as new nanomaterials for theranostics; imaging modalities that “switch-on” when miRNA is released will quantify how much nanomaterial gets to a specific site, while a built-in sens ....Multifunctional and Multimodal Theranostics: Manipulating Material Properties for Advanced Diagnostics. The utilisation of polymers in nanomedicine requires a bottom-up approach, where the fundamental chemistry is well-established and understood before it enables an application. This project develops branched polymers as new nanomaterials for theranostics; imaging modalities that “switch-on” when miRNA is released will quantify how much nanomaterial gets to a specific site, while a built-in sensor based on physical changes in the nanomaterial will measure the onset and progression of necrosis. The aim is to develop a fundamental understanding of how polymer architecture and functionality can be utilised to drive device performance, providing a platform to probe new technology and methodologies for development of next generation theranostics.Read moreRead less
Multimodal retinal imaging provides "insight" into cerebrovascular ageing. Multimodal retinal imaging provides "insight" into cerebrovascular ageing. This project aims to develop a multi-modal imaging technology platform to simultaneously measure amyloid beta and its neurovascular sequelae to identify novel early biomarkers of ageing in the eye and brain. The growing ageing population is an increasing socioeconomic burden. The central nervous system is particularly susceptible to ageing, which i ....Multimodal retinal imaging provides "insight" into cerebrovascular ageing. Multimodal retinal imaging provides "insight" into cerebrovascular ageing. This project aims to develop a multi-modal imaging technology platform to simultaneously measure amyloid beta and its neurovascular sequelae to identify novel early biomarkers of ageing in the eye and brain. The growing ageing population is an increasing socioeconomic burden. The central nervous system is particularly susceptible to ageing, which is difficult to measure at its onset. Critically, as the eye is an easily accessible extension of the cortex, retinal imaging may be a non-invasive surrogate to assess ageing changes in the brain. Anticipated outcomes are a sensitive detector of neural ageing, improved preventative measures, reducing the socioeconomic burden of ageing, and improved quality of life.Read moreRead less