Novel Targeted Degradable Multifunctional Poly(vinyl-co-ester) Nanoparticles For Alzheimer’s Disease Applications
Funder
National Health and Medical Research Council
Funding Amount
$601,940.00
Summary
Novel biodegradable polymeric nanoparticles for efficient and targeted delivery of Alzheimer related agents to the brain will be developed. The nanocarriers will be fabricated from biocompatible multifunctional compounds and possess the capability to co-deliver diagnostic and therapeutic agents across the blood-brain barrier. These systems are expected to become a new efficient class of brain delivery systems.
Boosting Effectiveness Of New Vaccines For Dengue ,HFMD And Influenza By Targeting Vaccine Antigens To Clec9A On Dendritic Cells.
Funder
National Health and Medical Research Council
Funding Amount
$396,332.00
Summary
Australian and Singapore laboratories will collaborate to develop improved vaccines against virus diseases, particularly Dengue, Hand Foot and Mouth Disease and Influenza. A novel technology will be used, the targeting of vaccines to a receptor on the surface of the dendritic cells that control immune responses. This will be used to boost responses to a series of vaccine candidates that are otherwise insufficiently immunogenic.