Engineering a technology platform for organoids. Protein delivery technologies hold great potential to improve organoids (miniature organs used as in vitro models), allowing a deep understanding of development. However, current limitations must be overcome - particularly cost, precision, and efficacy. This project will engineer delivery materials to improve the efficacy of organoids, allowing control over the location and timing of protein delivery. Outcomes will include a technology platform o ....Engineering a technology platform for organoids. Protein delivery technologies hold great potential to improve organoids (miniature organs used as in vitro models), allowing a deep understanding of development. However, current limitations must be overcome - particularly cost, precision, and efficacy. This project will engineer delivery materials to improve the efficacy of organoids, allowing control over the location and timing of protein delivery. Outcomes will include a technology platform of immediate use in the agriculture sector and for animal model alternatives. The benefit will be widespread, ensuring the growth and sustainability of our health and agriculture sector. The project will increase public understanding of protein delivery technologies, aiding in technology adoption.Read moreRead less
Genetic control of tissue growth in animals. This project aims to understand how the animal body grows. This project expects to generate new knowledge and understanding of the genetic programs that govern the size and shape of animal tissues, through use of cutting-edge genome editing approaches in laboratory animals. Expected outcomes of this project include the production of genetically engineered animals with altered tissue growth, development of new theories for how tissue growth is normal ....Genetic control of tissue growth in animals. This project aims to understand how the animal body grows. This project expects to generate new knowledge and understanding of the genetic programs that govern the size and shape of animal tissues, through use of cutting-edge genome editing approaches in laboratory animals. Expected outcomes of this project include the production of genetically engineered animals with altered tissue growth, development of new theories for how tissue growth is normally controlled and how it can be manipulated industrially. This should provide significant benefits, impacting stem cell biology (improving stem cell production), tissue engineering (improving growth of artificial tissues), veterinary science and agriculture (improving productivity).Read moreRead less
3D Structure determination of biomacromolecular assemblies from sparse data. This project has direct impact on pharmaceutical research: Biomacromolecular interactions are key points for pharmaceutical intervention and detailed structural knowledge of dynamic protein interactions can significantly accelerate drug development. Australia has invested in expensive instrumentation that can be used with new laboratory methods to obtain information on delicately balanced biomacromolecular interactions, ....3D Structure determination of biomacromolecular assemblies from sparse data. This project has direct impact on pharmaceutical research: Biomacromolecular interactions are key points for pharmaceutical intervention and detailed structural knowledge of dynamic protein interactions can significantly accelerate drug development. Australia has invested in expensive instrumentation that can be used with new laboratory methods to obtain information on delicately balanced biomacromolecular interactions, and how they malfunction in disease. This project will provide a computational framework to increase the impact of this investment by integrating measurements from a range of novel technologies and developing understanding of changes in structure of large protein complexes in different functional states.Read moreRead less
Global Indigenous rights and local effect in Central Australia: tracing relations of power and locating potentialities. This ethnographic study investigates the practice of Indigenous rights in central Australia by exploring the apparently entrenched disjunctures between the declaration of rights and social fact. Working with Aboriginal people, government and non-government organisations will reveal how rights are understood and negotiated, thus locating new pathways for change.
Understanding the mechanisms of ion conduction and drug action in voltage gated sodium channels. Voltage-gated sodium channels initiate electrical impulses in nerve and muscle and are the target of many local anaesthetic, anti-epileptic and anti-arrythmic drugs. The publication of atomic resolution structures of homologous proteins from bacteria in the last 18 months has now made it possible to gain a detailed understanding of how these channels work, and how they are influenced by drugs. This p ....Understanding the mechanisms of ion conduction and drug action in voltage gated sodium channels. Voltage-gated sodium channels initiate electrical impulses in nerve and muscle and are the target of many local anaesthetic, anti-epileptic and anti-arrythmic drugs. The publication of atomic resolution structures of homologous proteins from bacteria in the last 18 months has now made it possible to gain a detailed understanding of how these channels work, and how they are influenced by drugs. This project aims to determine the basis of ion permeation and selectivity in the channels and explain the mechanisms of action for a number of common drugs. This will provide a foundation for future drug development to target specific channels for improved treatment of epilepsy, chronic pain and arrythmias. Read moreRead less
The identification of Mycosphaerella graminicola effectors that promote pathogenicity on wheat. Fungal diseases are one of the greatest challenges to sustainable wheat production in the 21st century. Septoria tritici blotch is one such disease as it inflicts millions of tonnes in yield losses per annum. This project will identify the molecular basis of Septoria tritici blotch and assess its potential as an Australian biosecurity threat.
Fostering Safe Nanotechnology Research Focused on Critical Public Health Problems. This Project builds upon the applicant's unique interdisciplinary research and collaborations to develop an innovative framework for improving occupational health and safety standards of nanotechnology research at the Australian National University and fostering its focus on critical public health problems such as biosecurity, food and water safety, pollution control and equitable access to health technologies.
'Trading' Women's Rights in Transitions: Designing Diplomatic Interventions in Afghanistan and Myanmar. This project aims to examine the link between diplomatic negotiations and their impact on the shifting status of women during times of deep political change. It will assess three key areas of international diplomatic negotiations around peace agreements, aid, and security sector reform and assess how these negotiations affected women's status on the ground. It will seek to design approaches to ....'Trading' Women's Rights in Transitions: Designing Diplomatic Interventions in Afghanistan and Myanmar. This project aims to examine the link between diplomatic negotiations and their impact on the shifting status of women during times of deep political change. It will assess three key areas of international diplomatic negotiations around peace agreements, aid, and security sector reform and assess how these negotiations affected women's status on the ground. It will seek to design approaches to diplomatic interventions that may be more cognisant of gendered impacts and aim to benefit women.Read moreRead less
The science and engineering of defects and impurities in photovoltaic silicon. This project will create the knowledge and techniques that are essential to make low-cost, impure silicon suitable for producing highly efficient solar cells. This will help to drive down the cost of solar electricity, since the silicon material itself is a significant component of the overall cost of most photovoltaic modules.
Mobility Shocks: Understanding disruptions to Australian migration. This Fellowship aims to generate new knowledge about the impacts of the Covid-19 pandemic on human migration and mobility, in order to advance understanding of major disruptive changes to population movement more broadly. Fellowship outcomes will include designing innovative geospatial research methods, linking and analysing cutting-edge datasets, and building cross-sector collaborations, in order to develop a new theory of ‘Mob ....Mobility Shocks: Understanding disruptions to Australian migration. This Fellowship aims to generate new knowledge about the impacts of the Covid-19 pandemic on human migration and mobility, in order to advance understanding of major disruptive changes to population movement more broadly. Fellowship outcomes will include designing innovative geospatial research methods, linking and analysing cutting-edge datasets, and building cross-sector collaborations, in order to develop a new theory of ‘Mobility Shocks’. This will benefit Australia and its migration partners with new ideas, tools, evidence and expertise to help scholars, policy makers and practitioners to understand, anticipate, and manage future disruptive changes to human migration and mobility in the Australian context and beyond.Read moreRead less