Exploring the immunomodulatory potential of Natural Killer T cells. Natural Killer T cells (NKT cells) are an innate-like population of T cells that recognise a range of lipid based antigens when bound to the antigen-presenting molecule, CD1d. Once activated, NKT cells rapidly secrete a variety of cytokines. This project, in partnership with Vaxine Pty Ltd, aims to gain a basic understanding of NKT recognition of lipids and NKT cell activation by lipids. The project aims to use a combination of ....Exploring the immunomodulatory potential of Natural Killer T cells. Natural Killer T cells (NKT cells) are an innate-like population of T cells that recognise a range of lipid based antigens when bound to the antigen-presenting molecule, CD1d. Once activated, NKT cells rapidly secrete a variety of cytokines. This project, in partnership with Vaxine Pty Ltd, aims to gain a basic understanding of NKT recognition of lipids and NKT cell activation by lipids. The project aims to use a combination of cellular immunology and structural biology to gain insight into NKT cell agonism.Read moreRead less
ARC Communications Research Network. Building on a strong platform of existing research excellence, the Aim of the Network is to facilitate nation-wide collaborative research, promoting four intersecting research Themes: Mobile and Wireless Communications, Rural Communications, Broadband and Optical Networks, and Fundamentals of Emerging Media. Each Theme is formulated to drive multidisciplinary, innovative research as well as inspire new collaborative initiatives. Four Programs encapsulate the ....ARC Communications Research Network. Building on a strong platform of existing research excellence, the Aim of the Network is to facilitate nation-wide collaborative research, promoting four intersecting research Themes: Mobile and Wireless Communications, Rural Communications, Broadband and Optical Networks, and Fundamentals of Emerging Media. Each Theme is formulated to drive multidisciplinary, innovative research as well as inspire new collaborative initiatives. Four Programs encapsulate the core activities of the Network: Researcher Mobility, Workshops and Conferences, Postgraduate Education, and Knowledge Management Systems. The Network is expected to add significant value to pre-existing investments and raise the profile of Australian telecommunications research.Read moreRead less
Enhanced multivalent vaccine responses using a novel vaccine vector system. Enhanced multivalent vaccine responses using a novel vaccine vector system. This project aims to develop a multicomponent vaccine system to deliver equal effectiveness against several disease targets in a single administration. New and innovative vaccine design strategies incorporating economical commercial production processes are urgently needed for new and existing human and animal health applications. A vaccine capab ....Enhanced multivalent vaccine responses using a novel vaccine vector system. Enhanced multivalent vaccine responses using a novel vaccine vector system. This project aims to develop a multicomponent vaccine system to deliver equal effectiveness against several disease targets in a single administration. New and innovative vaccine design strategies incorporating economical commercial production processes are urgently needed for new and existing human and animal health applications. A vaccine capable of targeting multiple diseases by a single injection is an obvious way to expedite future vaccine development and deployment. However, the recipient’s immune system can repress equivalent responses to these multicomponent vaccines. This project’s research is expected to address these problems, and underpin the future commercial development of this vaccine platform.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120101161
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Compressive sensing based probabilistic graphical models (PGM). The aim of the project is to develop fast, large scale probabilistic graphical models (PGM) learning and inference methods. The resulting system will be able to process large scale PGMs on a standard PC, and will be easily extendable to computer clustering for larger scale PGMs requiring higher precision.
Efficient causal discovery from observational data. Discovering cause-effect relationships is the ultimate goal for many applications. Randomised control trial is the gold standard for discovering causal relationships. However, conducting such trials is impossible in many cases due to cost and/or ethical concerns. In contrast, a large amount of data has been accumulated in all areas. It is desirable to infer causal relationships from data directly and automatically. This project aims to develop ....Efficient causal discovery from observational data. Discovering cause-effect relationships is the ultimate goal for many applications. Randomised control trial is the gold standard for discovering causal relationships. However, conducting such trials is impossible in many cases due to cost and/or ethical concerns. In contrast, a large amount of data has been accumulated in all areas. It is desirable to infer causal relationships from data directly and automatically. This project aims to develop fast and scalable data mining methods for identifying causal relationships from large and/or high dimensional data sets. The developed methods will mainly be evaluated in real world biological applications. The research outcomes will be useful in many areas for causal reasoning and decision making.Read moreRead less
Fairness aware data mining for discrimination free decision-making. This project aims to develop data mining methods to detect algorithmic discriminations and to build fair decision models. It expects to provide techniques for regulatory organisations to detect discriminations in algorithmic decisions, and for various companies and organisations to build fair decision systems. Expected outcomes are novel and accurate methods for discrimination detection, practical and versatile techniques for fa ....Fairness aware data mining for discrimination free decision-making. This project aims to develop data mining methods to detect algorithmic discriminations and to build fair decision models. It expects to provide techniques for regulatory organisations to detect discriminations in algorithmic decisions, and for various companies and organisations to build fair decision systems. Expected outcomes are novel and accurate methods for discrimination detection, practical and versatile techniques for fair decision model building, and improved understanding of the relationships between privacy preservation and discrimination prevention to enable new techniques to achieve both goals. The developed techniques enable society to tackle ethical challenges in the big data era where many decisions are analytics based. Read moreRead less
Developing novel data mining methods to reveal complex group relationships from heterogeneous data. This project aims to develop novel and effective data mining methods that will enable us to unravel the relationships between multiple, rather than individual, components of complex systems (such as genes, gene regulators and cancer), which is crucial to understanding how such systems work. Potential applications for such methods are extensive.
Online Learning for Large Scale Structured Data in Complex Situations. Online Learning (OL) is the process of predicting answers for a sequence of questions. OL has enjoyed much attention in recent years due to its natural ability of processing large scale non-structured data and adapting to a changing environment. However, OL has three weaknesses: it does not scale for structured data; it often assumes that all of the data are equally important; it often considers that all of the data are compl ....Online Learning for Large Scale Structured Data in Complex Situations. Online Learning (OL) is the process of predicting answers for a sequence of questions. OL has enjoyed much attention in recent years due to its natural ability of processing large scale non-structured data and adapting to a changing environment. However, OL has three weaknesses: it does not scale for structured data; it often assumes that all of the data are equally important; it often considers that all of the data are complete and noise-free. These weaknesses limit its utility, because real data such as those that must be analysed in processing social networks, fraud detection do not satisfy the restrictions. The aim of this project is to develop theoretical and practical advances in OL that overcome the existing weaknesses.Read moreRead less
Probabilistic Graphical Models For Interventional Queries. The project intends to develop methods to suggest how to optimally intervene so that the future state of the system will best suit our interests. The power of probabilistic graphical models to model complex relationships and interactions among a large number of variables facilitates many applications. However, such models only aim to understand the underlying environment. What is ultimately needed in many real-world applications is to su ....Probabilistic Graphical Models For Interventional Queries. The project intends to develop methods to suggest how to optimally intervene so that the future state of the system will best suit our interests. The power of probabilistic graphical models to model complex relationships and interactions among a large number of variables facilitates many applications. However, such models only aim to understand the underlying environment. What is ultimately needed in many real-world applications is to suggest how we ought to intervene or act, so as to alter the environment to best suit our interests. The proposed project aims to achieve this using probabilistic graphical models on massive real-world data sets, thus facilitating a variety of applications from health care to commerce and the environment.Read moreRead less
The development of a potent new passive immunotherapeutic for the treatment and prevention of bacterial sepsis and septic shock. Bacterial sepsis and septic shock is a leading cause of death in hospital intensive care units and represents a significant public health burden. By developing a new passive immunotherapeutic regimen to treat and prevent bacterial sepsis and septic shock, the project aims to reverse the significant mortality and morbidity associated with this condition.