The Misinformation Future—Confronting Emerging Threats. Misinformation presents challenges to public health and democracy. Though psychological research has explored processing mechanisms and countermeasures, new threats are arising that need to be confronted. This project aims to help meet these threats by (a) investigating misinformation impacts on future-oriented cognition and behaviours, with a focus on global long-term issues and (b) addressing the unique challenges posed by visual and synt ....The Misinformation Future—Confronting Emerging Threats. Misinformation presents challenges to public health and democracy. Though psychological research has explored processing mechanisms and countermeasures, new threats are arising that need to be confronted. This project aims to help meet these threats by (a) investigating misinformation impacts on future-oriented cognition and behaviours, with a focus on global long-term issues and (b) addressing the unique challenges posed by visual and synthetic (AI-generated) misinformation. The expected outcome is new knowledge on the processing and impacts of emerging types of misinformation and translation into practical interventions. These promise to benefit consumers, educators and policymakers, contributing to a healthier information environment.Read moreRead less
Combating Misinformation – Designing a Toolkit to Address a Global Problem. Misinformation impairs people’s cognition – their memory, reasoning and judgements – even if credible corrections are issued; it therefore poses a significant threat to evidence-based practice and policy. This project aims to develop novel psychological interventions to reduce the impact of misinformation, based on an experimental research program designed to systematically assess the effects of various types of misinfor ....Combating Misinformation – Designing a Toolkit to Address a Global Problem. Misinformation impairs people’s cognition – their memory, reasoning and judgements – even if credible corrections are issued; it therefore poses a significant threat to evidence-based practice and policy. This project aims to develop novel psychological interventions to reduce the impact of misinformation, based on an experimental research program designed to systematically assess the effects of various types of misinformation on cognition and behaviour. The expected outcome is the development of new knowledge regarding misinformation processing and communication and its translation into a toolkit for practical application. This promises to improve individual and public decision making and foster a culture of accurate information exchange.Read moreRead less
IDENTIFYING CONTROL ELEMENTS IN CHLOROPLAST GENE EXPRESSION. Energy from sunlight is captured by photosynthesis in plants, providing the basis for the terrestrial food chain. This process takes place in chloroplasts, subcellular structures that derived from photosynthetic bacteria a billion years ago. Chloroplasts have their own DNA, containing genes encoding the most important photosynthetic proteins. This project aims to provide the world’s best resources for the study of chloroplast genes. In ....IDENTIFYING CONTROL ELEMENTS IN CHLOROPLAST GENE EXPRESSION. Energy from sunlight is captured by photosynthesis in plants, providing the basis for the terrestrial food chain. This process takes place in chloroplasts, subcellular structures that derived from photosynthetic bacteria a billion years ago. Chloroplasts have their own DNA, containing genes encoding the most important photosynthetic proteins. This project aims to provide the world’s best resources for the study of chloroplast genes. In the process, we will discover how these important genes are regulated to provide photosynthetic proteins in the right amounts, in the right cells, at the right time. The knowledge and resources gained will facilitate improvement of photosynthetic function in future agricultural crops.Read moreRead less
Accuracy and cost-effectiveness of technology-assisted dietary assessment. This project aims to compare leading methods for technology-assisted dietary assessment. Excessive cost and questionable accuracy limit the routine use of dietary assessment and undermine decision making in Australia. This project intends to compare three technology methods of assessing diet with the current standard recall method used in population surveys in order to confirm if the use of food images and automated metho ....Accuracy and cost-effectiveness of technology-assisted dietary assessment. This project aims to compare leading methods for technology-assisted dietary assessment. Excessive cost and questionable accuracy limit the routine use of dietary assessment and undermine decision making in Australia. This project intends to compare three technology methods of assessing diet with the current standard recall method used in population surveys in order to confirm if the use of food images and automated methods provide new approaches to improve accuracy and consumer acceptability. Expected outcomes of this project include more accurate and acceptable methods of assessing dietary intake. These findings will inform decision making for researchers, policy makers and practitioners in Australia, and potentially lead to more regular population surveillance.Read moreRead less
Mastering pyrimidine editing in RNA. Many plants and animals can alter their genetic information via RNA (ribonucleic acid) editing, a process that is often essential for the growth and development of the organism. This ability provides accurate control over gene expression and has great potential as a biotechnological tool in agriculture and medicine. RNA editing could be used to switch genes on or off in biotechnological production systems with an unprecedented degree of precision, or to corre ....Mastering pyrimidine editing in RNA. Many plants and animals can alter their genetic information via RNA (ribonucleic acid) editing, a process that is often essential for the growth and development of the organism. This ability provides accurate control over gene expression and has great potential as a biotechnological tool in agriculture and medicine. RNA editing could be used to switch genes on or off in biotechnological production systems with an unprecedented degree of precision, or to correct genetic diseases. This project aims to understand two RNA editing pathways in plants, one of which is found nowhere else and likely to involve a novel enzymatic mechanism. We will use the understanding gained to develop novel RNA processing tools usable in any living organism.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240101210
Funder
Australian Research Council
Funding Amount
$375,837.00
Summary
A liquid protein platform for dynamic bio-inspired reaction compartments. This project aims to investigate liquid protein as a novel material for biotechnology by producing protein droplets with a range of material and structural properties and assess the activity of internalised enzymes. The project will combine concepts from protein-based subcellular super-structure and enzyme protein structure and apply cutting-edge biochemistry methods to study how catalysis can be controlled and directed th ....A liquid protein platform for dynamic bio-inspired reaction compartments. This project aims to investigate liquid protein as a novel material for biotechnology by producing protein droplets with a range of material and structural properties and assess the activity of internalised enzymes. The project will combine concepts from protein-based subcellular super-structure and enzyme protein structure and apply cutting-edge biochemistry methods to study how catalysis can be controlled and directed through liquid protein design. Expected outcomes include a new platform for using protein droplets to engineer dynamic catalytic compartments, strong international and interdisciplinary collaborations, and a knowledge-base for building synthetic biology tools and technologies for future green chemistry-based industries.Read moreRead less
Engineering self-assembled intracellular biological condensates. Cells depend on proteins linking together to build cellular structure, but how weak interactions build stable structure is a mystery. New evidence suggests proteins come together and then change state, employing liquid-like behaviour that builds vital nanoscale structure, such as nuclear bodies called paraspeckles. This project will unlock the secrets of this mysterious behavior of proteins, using paraspeckles as a model. We will u ....Engineering self-assembled intracellular biological condensates. Cells depend on proteins linking together to build cellular structure, but how weak interactions build stable structure is a mystery. New evidence suggests proteins come together and then change state, employing liquid-like behaviour that builds vital nanoscale structure, such as nuclear bodies called paraspeckles. This project will unlock the secrets of this mysterious behavior of proteins, using paraspeckles as a model. We will use this information for nanotechnology application to build a synthetic paraspeckle inspired structure with bespoke function. Benefits will include new concepts in how vital cell structure is assembled and disassembled, and nanotechnology and synthetic biology tools to manipulate cellular processes.Read moreRead less
Advancing plant synthetic gene circuit capability, robustness, and use. This project aims to advance our ability to control gene expression in plants using synthetic gene circuits. By expanding the toolkit and optimizing circuit components, we aim to achieve more complex capabilities and robust implementation. Furthermore, we will apply gene circuit technologies to enhance plant frost tolerance. The expected project outcomes include a significant advance in gene circuit capabilities, a better un ....Advancing plant synthetic gene circuit capability, robustness, and use. This project aims to advance our ability to control gene expression in plants using synthetic gene circuits. By expanding the toolkit and optimizing circuit components, we aim to achieve more complex capabilities and robust implementation. Furthermore, we will apply gene circuit technologies to enhance plant frost tolerance. The expected project outcomes include a significant advance in gene circuit capabilities, a better understanding of their behavior in plant cells, and the ability to use them to confer advantageous traits. The benefits of this research include new plant biotechnology tools that will underpin future crop yield improvements, and advances in plant-based pharmaceuticals and materials.Read moreRead less