Towards a cognitive process model of how attention and choice interact. Before making any decision, we must gather information on what options are available. This process may influence the choices we make: if we do not notice an option, we will not choose it even if it would have been valuable. This project aims to examine how prior experience can produce attentional biases that influence decisions, and will develop a new computational model of this interaction of attention and choice as an outc ....Towards a cognitive process model of how attention and choice interact. Before making any decision, we must gather information on what options are available. This process may influence the choices we make: if we do not notice an option, we will not choose it even if it would have been valuable. This project aims to examine how prior experience can produce attentional biases that influence decisions, and will develop a new computational model of this interaction of attention and choice as an outcome. This new knowledge will enhance the world-class status of Australian cognitive psychology. Moreover, it should provide significant benefits through improving our ability to predict and shape behaviour, and shedding light on the role of biases in healthy cognition and in the context of compulsive behaviours.Read moreRead less
Poly(amino acids) as immune stimulators. This project aims to develop nanoparticles built from natural hydrophobic amino acids as an immune stimulatory delivery system for peptide antigens. Currently available immune stimulants (adjuvants) are often toxic and/or are poorly chemically defined fragments of bacteria or toxins and vary from batch-to-batch. New adjuvants are in high demand; especially to facilitate the use of optimal, but weakly immunogenic, peptide antigens. It is expected that the ....Poly(amino acids) as immune stimulators. This project aims to develop nanoparticles built from natural hydrophobic amino acids as an immune stimulatory delivery system for peptide antigens. Currently available immune stimulants (adjuvants) are often toxic and/or are poorly chemically defined fragments of bacteria or toxins and vary from batch-to-batch. New adjuvants are in high demand; especially to facilitate the use of optimal, but weakly immunogenic, peptide antigens. It is expected that the proposed project will develop a novel efficient, safe and notably biodegradable self-adjuvanting delivery system that can be fully customised to match an antigen of choice. This foundational research should provide important advances for commercial immune stimulatory applications.Read moreRead less
A statistical decision theory of cognitive capacity. This project aims to investigate the limited capacity of the human cognitive system to form representations of the things in the world around us and to make decisions about them in real time. Its goal is to provide an integrated theory of cognitive capacity based on the statistical properties of cognitive representations and the decision processes that act on them. Its expected outcome will be a unified metric for cognitive capacity that will ....A statistical decision theory of cognitive capacity. This project aims to investigate the limited capacity of the human cognitive system to form representations of the things in the world around us and to make decisions about them in real time. Its goal is to provide an integrated theory of cognitive capacity based on the statistical properties of cognitive representations and the decision processes that act on them. Its expected outcome will be a unified metric for cognitive capacity that will allow us to quantify how cognitive load affects the speed and accuracy of decision making. It will benefit the design and evaluation of high workload real-time decision systems and will contribute to the selection and training of users of such systems.
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Determining principles for successful episode retrieval of repeated events. This project aims to develop the first-ever set of explanatory principles for how people successfully retain and retrieve individual episode memories from repeated experiences (e.g., one occurrence of a routine social encounter or job-related activity). By deepening our understanding of how memory works, this new knowledge is expected to lay the foundation for interview guidance and ongoing research aimed at enhancing th ....Determining principles for successful episode retrieval of repeated events. This project aims to develop the first-ever set of explanatory principles for how people successfully retain and retrieve individual episode memories from repeated experiences (e.g., one occurrence of a routine social encounter or job-related activity). By deepening our understanding of how memory works, this new knowledge is expected to lay the foundation for interview guidance and ongoing research aimed at enhancing the proficiency of investigations into matters that rely on detailed and accurate accounts of specific episodes. This includes workplace or traffic accident investigations, infectious disease contact tracing, as well as prosecution of repeated sexual offences.Read moreRead less
Augmenting the activity of glyoxalase-1 to increase dicarbonyl clearance . Reactive intermediates generated during our metabolism contribute to ageing. Glyoxalase-1 is a key defence enzyme against these toxic intermediates and therefore ageing itself. This project aims to investigate novel pathways how the expression and activity of glyoxalase-1 are regulated. This interdisciplinary project expects to generate new understanding by combining relevant cell and animal models, protein chemistry, epi ....Augmenting the activity of glyoxalase-1 to increase dicarbonyl clearance . Reactive intermediates generated during our metabolism contribute to ageing. Glyoxalase-1 is a key defence enzyme against these toxic intermediates and therefore ageing itself. This project aims to investigate novel pathways how the expression and activity of glyoxalase-1 are regulated. This interdisciplinary project expects to generate new understanding by combining relevant cell and animal models, protein chemistry, epigenetics and structural biology. It is expected that this work will improve understanding of this fundamental biological defence. This will allow us to identify the potential means to enhance the capacity of glyoxalase-1 to the future benefit of biological ageing.Read moreRead less
Using cognitive models to understand memorability of real world images. This proposal aims to understand and make predictions about which real world images -- specifically living things, objects, and human faces -- that people will remember remember via an integration of cognitive models of memory and machine learning techniques. Computer vision models and similarity scaling techniques will be used to produce psychological representations of the images. These representations will then be integra ....Using cognitive models to understand memorability of real world images. This proposal aims to understand and make predictions about which real world images -- specifically living things, objects, and human faces -- that people will remember remember via an integration of cognitive models of memory and machine learning techniques. Computer vision models and similarity scaling techniques will be used to produce psychological representations of the images. These representations will then be integrated with cognitive models of memory, which predict that images are more likely to be recognized if they are similar to each of the representations in memory. Large scale memory and similarity rating datasets will be used to develop and test the model.Read moreRead less
The Misinformation Future—Confronting Emerging Threats. Misinformation presents challenges to public health and democracy. Though psychological research has explored processing mechanisms and countermeasures, new threats are arising that need to be confronted. This project aims to help meet these threats by (a) investigating misinformation impacts on future-oriented cognition and behaviours, with a focus on global long-term issues and (b) addressing the unique challenges posed by visual and synt ....The Misinformation Future—Confronting Emerging Threats. Misinformation presents challenges to public health and democracy. Though psychological research has explored processing mechanisms and countermeasures, new threats are arising that need to be confronted. This project aims to help meet these threats by (a) investigating misinformation impacts on future-oriented cognition and behaviours, with a focus on global long-term issues and (b) addressing the unique challenges posed by visual and synthetic (AI-generated) misinformation. The expected outcome is new knowledge on the processing and impacts of emerging types of misinformation and translation into practical interventions. These promise to benefit consumers, educators and policymakers, contributing to a healthier information environment.Read moreRead less
Human Scheduling of Perceptual Tasks. This project aims to develop a novel approach for synthesising how people prioritise information with theories of attention and decision making. Characterising inefficient scheduling in the tradeoff between the difficulty and the cost/benefit of different subtasks will allow the development of a formal computional model that generalises statistical models of rank order data to a theory of the timing of scheduling decisions and task completions. Outcomes incl ....Human Scheduling of Perceptual Tasks. This project aims to develop a novel approach for synthesising how people prioritise information with theories of attention and decision making. Characterising inefficient scheduling in the tradeoff between the difficulty and the cost/benefit of different subtasks will allow the development of a formal computional model that generalises statistical models of rank order data to a theory of the timing of scheduling decisions and task completions. Outcomes include benchmark data from a novel paradigm for studying perceptual decisions and behavior and a model which can explain and predict human scheduling. This project aims to benefit industry by allowing for the simulation of information prioritisation by human agents in complex environments.Read moreRead less
Signaling in the crypt: a novel metabolic pathway in intestinal stem cells. The gut is the most rapidly renewing tissue in the body, driven by a highly active stem cell niche. Bile acids are emerging as critical regulators of this stem cell niche and disruption of bile acid homeostasis has profoundly adverse effects on intestinal renewal and hence gut health. We are addressing a critical gap in our understanding of how bile acids are controlled within stem cell niche. The aim of the project is ....Signaling in the crypt: a novel metabolic pathway in intestinal stem cells. The gut is the most rapidly renewing tissue in the body, driven by a highly active stem cell niche. Bile acids are emerging as critical regulators of this stem cell niche and disruption of bile acid homeostasis has profoundly adverse effects on intestinal renewal and hence gut health. We are addressing a critical gap in our understanding of how bile acids are controlled within stem cell niche. The aim of the project is to define the critical role of a novel enzyme called UGT8 in controlling intestinal stem cell response to bile acids; this is achieved by modulating UGT8 activity in intestinal stem cell models and determining the effects on stem cell function and the key signalling pathways that control intestinal homeostasis and renewal.Read moreRead less
Unravelling the complexities of cell death pathways . This project aims to test if cells can flexibly rewire their cell death pathways to ensure that the absence or inhibition of one type of cell death can be compensated through the triggering of another. The project expects to generate new knowledge in the area of programed cell death, and more specifically will address why cells have multiple programmed ways to die. Expected outcomes of this project include the provision of unprecedented insig ....Unravelling the complexities of cell death pathways . This project aims to test if cells can flexibly rewire their cell death pathways to ensure that the absence or inhibition of one type of cell death can be compensated through the triggering of another. The project expects to generate new knowledge in the area of programed cell death, and more specifically will address why cells have multiple programmed ways to die. Expected outcomes of this project include the provision of unprecedented insights into the molecular regulation of how cells orchestrate and integrate cell death pathways. This should provide significant benefits, such as providing the knowledge base needed to improve our abilities to manipulate cell death both in basic research and commercial applications of cell death.Read moreRead less