Discovery Early Career Researcher Award - Grant ID: DE240100827
Funder
Australian Research Council
Funding Amount
$458,737.00
Summary
Delineating the developmental requirements for stem-like T cells. Stem-like CD8 T cells are critical for sustaining long-term systemic T cell activity. The signalling required for their development, however, remains elusive. Integrating multidisciplinary expertise, cutting-edge technology and highly innovative methods, this project aims to define the signalling cues provided by tissue microenvironment that control the development and maintenance of stem-like T cells, and thereby dictate systemic ....Delineating the developmental requirements for stem-like T cells. Stem-like CD8 T cells are critical for sustaining long-term systemic T cell activity. The signalling required for their development, however, remains elusive. Integrating multidisciplinary expertise, cutting-edge technology and highly innovative methods, this project aims to define the signalling cues provided by tissue microenvironment that control the development and maintenance of stem-like T cells, and thereby dictate systemic immunity. This project is expected to generate fundamental knowledge on basic immunology and T cell biology, which can benefit the academic, public health and biotechnology sectors by enhancing the international standing of Australian research on basic immunology and fostering new commercial opportunities. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100106
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Measuring interference from prior memories using experience sampling. The project aims to better understand the causes of forgetting in recognition memory. This project will measure participants' experiences using smartphone technology for four weeks before a recognition memory experiment. Similarities between the images in the experiment and images in prior experience can be used to fully specify all interference components within a computational model of recognition memory, leading to a comple ....Measuring interference from prior memories using experience sampling. The project aims to better understand the causes of forgetting in recognition memory. This project will measure participants' experiences using smartphone technology for four weeks before a recognition memory experiment. Similarities between the images in the experiment and images in prior experience can be used to fully specify all interference components within a computational model of recognition memory, leading to a complete model of recognition memory. Better understanding the causes of forgetting in recognition memory could show how interference contributes to memory impairments in ageing, and ultimately Alzheimer’s and other clinical disorders.Read moreRead less
A statistical decision theory of cognitive capacity. This project aims to investigate the limited capacity of the human cognitive system to form representations of the things in the world around us and to make decisions about them in real time. Its goal is to provide an integrated theory of cognitive capacity based on the statistical properties of cognitive representations and the decision processes that act on them. Its expected outcome will be a unified metric for cognitive capacity that will ....A statistical decision theory of cognitive capacity. This project aims to investigate the limited capacity of the human cognitive system to form representations of the things in the world around us and to make decisions about them in real time. Its goal is to provide an integrated theory of cognitive capacity based on the statistical properties of cognitive representations and the decision processes that act on them. Its expected outcome will be a unified metric for cognitive capacity that will allow us to quantify how cognitive load affects the speed and accuracy of decision making. It will benefit the design and evaluation of high workload real-time decision systems and will contribute to the selection and training of users of such systems.
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Discovery Early Career Researcher Award - Grant ID: DE240101348
Funder
Australian Research Council
Funding Amount
$470,999.00
Summary
Synergies between physical exercise, brain stimulation, and neuroplasticity. The brain is a highly dynamic organ. This capacity, known as neuroplasticity, governs our ability to learn new skills, acquire new knowledge, and fine-tune cognition. This project aims to investigate synergies between exercise, brain stimulation, and neuroplasticity, via application of a highly innovative interdisciplinary approach combining exercise physiology and cognitive neuroscience techniques. This project will pi ....Synergies between physical exercise, brain stimulation, and neuroplasticity. The brain is a highly dynamic organ. This capacity, known as neuroplasticity, governs our ability to learn new skills, acquire new knowledge, and fine-tune cognition. This project aims to investigate synergies between exercise, brain stimulation, and neuroplasticity, via application of a highly innovative interdisciplinary approach combining exercise physiology and cognitive neuroscience techniques. This project will pioneer novel, non-invasive methods of harnessing neuroplasticity to improve brain function, and generate fundamental insights into the mechanisms mediating learning and memory. Read moreRead less
Augmenting the activity of glyoxalase-1 to increase dicarbonyl clearance . Reactive intermediates generated during our metabolism contribute to ageing. Glyoxalase-1 is a key defence enzyme against these toxic intermediates and therefore ageing itself. This project aims to investigate novel pathways how the expression and activity of glyoxalase-1 are regulated. This interdisciplinary project expects to generate new understanding by combining relevant cell and animal models, protein chemistry, epi ....Augmenting the activity of glyoxalase-1 to increase dicarbonyl clearance . Reactive intermediates generated during our metabolism contribute to ageing. Glyoxalase-1 is a key defence enzyme against these toxic intermediates and therefore ageing itself. This project aims to investigate novel pathways how the expression and activity of glyoxalase-1 are regulated. This interdisciplinary project expects to generate new understanding by combining relevant cell and animal models, protein chemistry, epigenetics and structural biology. It is expected that this work will improve understanding of this fundamental biological defence. This will allow us to identify the potential means to enhance the capacity of glyoxalase-1 to the future benefit of biological ageing.Read moreRead less
Using cognitive models to understand memorability of real world images. This proposal aims to understand and make predictions about which real world images -- specifically living things, objects, and human faces -- that people will remember remember via an integration of cognitive models of memory and machine learning techniques. Computer vision models and similarity scaling techniques will be used to produce psychological representations of the images. These representations will then be integra ....Using cognitive models to understand memorability of real world images. This proposal aims to understand and make predictions about which real world images -- specifically living things, objects, and human faces -- that people will remember remember via an integration of cognitive models of memory and machine learning techniques. Computer vision models and similarity scaling techniques will be used to produce psychological representations of the images. These representations will then be integrated with cognitive models of memory, which predict that images are more likely to be recognized if they are similar to each of the representations in memory. Large scale memory and similarity rating datasets will be used to develop and test the model.Read moreRead less
Human Scheduling of Perceptual Tasks. This project aims to develop a novel approach for synthesising how people prioritise information with theories of attention and decision making. Characterising inefficient scheduling in the tradeoff between the difficulty and the cost/benefit of different subtasks will allow the development of a formal computional model that generalises statistical models of rank order data to a theory of the timing of scheduling decisions and task completions. Outcomes incl ....Human Scheduling of Perceptual Tasks. This project aims to develop a novel approach for synthesising how people prioritise information with theories of attention and decision making. Characterising inefficient scheduling in the tradeoff between the difficulty and the cost/benefit of different subtasks will allow the development of a formal computional model that generalises statistical models of rank order data to a theory of the timing of scheduling decisions and task completions. Outcomes include benchmark data from a novel paradigm for studying perceptual decisions and behavior and a model which can explain and predict human scheduling. This project aims to benefit industry by allowing for the simulation of information prioritisation by human agents in complex environments.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100259
Funder
Australian Research Council
Funding Amount
$467,964.00
Summary
Interrogating the adaptive potential of skeletal muscle. Disruptions to muscle oxidative capacity and growth signalling underpin atrophy and dysfunction with ageing, which impacts on an individual’s quality of life. These biological processes are thought to be mutually exclusive and compete during muscle adaptation. This project aims to define how these processes regulate the extent of muscle adaptation, and how modifying these attributes influence functional capacity in the context of ageing. T ....Interrogating the adaptive potential of skeletal muscle. Disruptions to muscle oxidative capacity and growth signalling underpin atrophy and dysfunction with ageing, which impacts on an individual’s quality of life. These biological processes are thought to be mutually exclusive and compete during muscle adaptation. This project aims to define how these processes regulate the extent of muscle adaptation, and how modifying these attributes influence functional capacity in the context of ageing. This project will provide fundamental new knowledge in understanding how modifying muscle attributes influence successful ageing. This knowledge will improve resilience, productivity, and wellbeing of all Australians, with implications for reducing societal and economic burden.Read moreRead less
Unravelling the complexities of cell death pathways . This project aims to test if cells can flexibly rewire their cell death pathways to ensure that the absence or inhibition of one type of cell death can be compensated through the triggering of another. The project expects to generate new knowledge in the area of programed cell death, and more specifically will address why cells have multiple programmed ways to die. Expected outcomes of this project include the provision of unprecedented insig ....Unravelling the complexities of cell death pathways . This project aims to test if cells can flexibly rewire their cell death pathways to ensure that the absence or inhibition of one type of cell death can be compensated through the triggering of another. The project expects to generate new knowledge in the area of programed cell death, and more specifically will address why cells have multiple programmed ways to die. Expected outcomes of this project include the provision of unprecedented insights into the molecular regulation of how cells orchestrate and integrate cell death pathways. This should provide significant benefits, such as providing the knowledge base needed to improve our abilities to manipulate cell death both in basic research and commercial applications of cell death.Read moreRead less
EFR3: Novel gatekeeper of cell proliferation. This interdisciplinary, cross-institutional project uses leading-edge mass spectrometry and the yeast genetic model to enhance knowledge of fundamental signalling mechanisms common to cell proliferation of eukaryotic cells. Building on extensive preliminary data that identifies novel energy-stress control points, this research will generate insights into critical and conserved features of nutrient stress control of cell proliferation that ensures cel ....EFR3: Novel gatekeeper of cell proliferation. This interdisciplinary, cross-institutional project uses leading-edge mass spectrometry and the yeast genetic model to enhance knowledge of fundamental signalling mechanisms common to cell proliferation of eukaryotic cells. Building on extensive preliminary data that identifies novel energy-stress control points, this research will generate insights into critical and conserved features of nutrient stress control of cell proliferation that ensures cell survival. This project advances basic and applied biology. Its outcomes will be relevant to several research areas and industries, specifically to the propagation of cell cultures that nowadays contributes to the production of a myriad of biotechnical and pharmaceutical commodities.
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