Towards a high density silicon phase change memory device. This project builds upon our exciting recent findings that amorphous silicon can be transformed to a conducting crystalline phase following small-scale indentation. Furthermore the process is reversible as re-indentation can induce a transformation back to insulating amorphous silicon. This process appears to occur in extremely small (nanoscale) volumes of silicon. We plan to explore the viability of exploiting this behaviour to develo ....Towards a high density silicon phase change memory device. This project builds upon our exciting recent findings that amorphous silicon can be transformed to a conducting crystalline phase following small-scale indentation. Furthermore the process is reversible as re-indentation can induce a transformation back to insulating amorphous silicon. This process appears to occur in extremely small (nanoscale) volumes of silicon. We plan to explore the viability of exploiting this behaviour to develop an entirely new information storage system: a high-density silicon phase change memory. This project aims to study small-scale transformation behaviour in silicon and to design demonstrator memory devices based on both micro-electromechanical systems and solid state technologies.Read moreRead less
Investigating The Cellular Response To Iron-Depletion: The Trilogy Of ASK1, Thioredoxin And Ribonucleotide Reductase
Funder
National Health and Medical Research Council
Funding Amount
$552,572.00
Summary
Iron is crucial for many essential biological processes. Recently, we demonstrated that iron-depletion can affects important signalling pathways (e.g., JNK and p38) that play important roles in growth arrest and apoptosis. This study is designed to investigate the cellular and molecular effects of iron depletion which currently remains unclear. The research is crucial for understanding: (1) the effects of iron deficiency and (2) for understanding the effects of iron chelators that are used for t ....Iron is crucial for many essential biological processes. Recently, we demonstrated that iron-depletion can affects important signalling pathways (e.g., JNK and p38) that play important roles in growth arrest and apoptosis. This study is designed to investigate the cellular and molecular effects of iron depletion which currently remains unclear. The research is crucial for understanding: (1) the effects of iron deficiency and (2) for understanding the effects of iron chelators that are used for treating various diseases.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453295
Funder
Australian Research Council
Funding Amount
$369,697.00
Summary
NMR cryosystem for structural and functional biology. State-of-the-art hardware is requested for the 600-MHz NMR spectrometers situated at University of Sydney and UNSW. A cryosystem installed at USyd. will provide a massive boost in productivity and will allow projects previously inaccessible due to excessive turn-around times, or sensitivity or solubility problems to become tractable. This system will provide new opportunities to researchers from USyd., UNSW and ANU, but will restrict the ver ....NMR cryosystem for structural and functional biology. State-of-the-art hardware is requested for the 600-MHz NMR spectrometers situated at University of Sydney and UNSW. A cryosystem installed at USyd. will provide a massive boost in productivity and will allow projects previously inaccessible due to excessive turn-around times, or sensitivity or solubility problems to become tractable. This system will provide new opportunities to researchers from USyd., UNSW and ANU, but will restrict the versatility of the USyd. instrument. The installation of a TBI probe at UNSW will counter this, and provide a REAL network of NMR instruments across NSW and the ACT.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989084
Funder
Australian Research Council
Funding Amount
$275,000.00
Summary
Confocal Laser Scanning Microscopy for Live Cell Imaging. The University of Newcastle has invested heavily in its biological and life sciences to create a research nexus focusing on national research priorities in biotechnology and environmental protection. The Live Cell Imaging platform will be utilized by scientists researching such strategically important areas including developmental biology, intracellular signalling cascades, cell cycle dynamics, plant development and microbiology. Moreover ....Confocal Laser Scanning Microscopy for Live Cell Imaging. The University of Newcastle has invested heavily in its biological and life sciences to create a research nexus focusing on national research priorities in biotechnology and environmental protection. The Live Cell Imaging platform will be utilized by scientists researching such strategically important areas including developmental biology, intracellular signalling cascades, cell cycle dynamics, plant development and microbiology. Moreover, this component of the University's research portfolio plays a major role in the postgraduate training of young Australian scientists who will, in turn, fuel future developments in both the life sciences and biotechnology industries.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668421
Funder
Australian Research Council
Funding Amount
$650,000.00
Summary
A MEG-based cognitive neuroscience laboratory. At present there is no MEG system in Australia, whereas MEG systems are currently springing up in research institutions in many other countries across the globe. This project will enable Australia to remain at the forefront of research in the cognitive neurosciences, as well as provide training opportunities to Australian doctoral students and postdoctoral fellows in the use of MEG in research. Finally, the MEG laboratory will allow Australian resea ....A MEG-based cognitive neuroscience laboratory. At present there is no MEG system in Australia, whereas MEG systems are currently springing up in research institutions in many other countries across the globe. This project will enable Australia to remain at the forefront of research in the cognitive neurosciences, as well as provide training opportunities to Australian doctoral students and postdoctoral fellows in the use of MEG in research. Finally, the MEG laboratory will allow Australian researchers to fill important gaps in our understanding of several areas of cognitive neuroscience, including basic auditory and visual processing, the study of cognitive processing in schizophrenia and in children with dyslexia and/or specific language impairment.Read moreRead less
Towards efficient real-time generation of detectable musical macrostructure. Efficient generation of detectable large scale musical structure is needed for commercial audiovisual applications, and for creative music making. But computer mediation of music has focused elsewhere: on sound synthesis and sequencing, editing, mixing and notation. I will apply computational processes like the handling of chunks of genetic information in evolution, to generate large scale musical structure. I will con ....Towards efficient real-time generation of detectable musical macrostructure. Efficient generation of detectable large scale musical structure is needed for commercial audiovisual applications, and for creative music making. But computer mediation of music has focused elsewhere: on sound synthesis and sequencing, editing, mixing and notation. I will apply computational processes like the handling of chunks of genetic information in evolution, to generate large scale musical structure. I will control segmentation; framing of internal segments; spatialisation; and the overlaying of separable musical streams. Expert cognitive assessment of the resultant structures will be investigated, and theories of segmentation, streaming and their relationships with expression and affect developed and tested.Read moreRead less
Cellular signals controlling oocyte activation. This research will significantly advance our understanding of the basic biological processes that underpin the fertility rate of all mammals and are key to the immediate and future health and well-being of Australian landscape and society. Understanding the processes that maintain healthy quiescent oocytes over many years before activation and subsequent growth will enable development of methods of increasing productivity in domestic animals and en ....Cellular signals controlling oocyte activation. This research will significantly advance our understanding of the basic biological processes that underpin the fertility rate of all mammals and are key to the immediate and future health and well-being of Australian landscape and society. Understanding the processes that maintain healthy quiescent oocytes over many years before activation and subsequent growth will enable development of methods of increasing productivity in domestic animals and enhancing fertility in endangered species. Knowledge of these cellular mechanisms will underpin biotechnology platforms necessary for novel methods of feral animal population control thus contributing at multiple levels to an economically sustainable Australia.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0214135
Funder
Australian Research Council
Funding Amount
$492,000.00
Summary
High performance protein crystallography. This proposal will provide state of the art high performance facilities for protein crystallography, bringing together the major structural biology groups in NSW and the ACT. A renewed focus on protein crystal structures will stimulate new interpretation and utilization of the vast amount of data that has come from genomics, especially the sequencing of the human genome. The proposed facility will generate new research collaborations between the partn ....High performance protein crystallography. This proposal will provide state of the art high performance facilities for protein crystallography, bringing together the major structural biology groups in NSW and the ACT. A renewed focus on protein crystal structures will stimulate new interpretation and utilization of the vast amount of data that has come from genomics, especially the sequencing of the human genome. The proposed facility will generate new research collaborations between the partner institutions which will result in advances in basic life sciences, biotechnology and biopharmaceuticals. The facility will complement regional initiatives in functional genomics, bioinformatics, proteomics and high-field NMR spectroscopy.Read moreRead less