Microenvironments which support extramedullary hematopoiesis. Tissue regeneration is a breakthrough technology absolutely dependent on knowledge of the stem cells and stromal cells which support differentiation and tissue development. This project investigates the stromal cell types in spleen which can regenerate blood-forming cells in an ectopic tissue site or artificial matrix.
ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory ne ....ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory networks and to address how environmental factors impinge on these regulatory networks. The formation of this National Research Network is unique, timely and strategic. It will generate new insights into the mechanisms by which events in early life determine the risk of adverse outcomes in perinatal and adult life.Read moreRead less
ARC Centre of Excellence in Biotechnology and Development. The Centre will create a multidisciplinary research team focusing on the molecular mechanisms that drive the specification and differentiation of male germ cells. This research will improve our fundamental understanding of how complex regulatory networks control the expression of a complex phenotype, the spermatozoon. It will also create a platform of knowledge from which we can stimulate the growth of the Australian Biotechnology indust ....ARC Centre of Excellence in Biotechnology and Development. The Centre will create a multidisciplinary research team focusing on the molecular mechanisms that drive the specification and differentiation of male germ cells. This research will improve our fundamental understanding of how complex regulatory networks control the expression of a complex phenotype, the spermatozoon. It will also create a platform of knowledge from which we can stimulate the growth of the Australian Biotechnology industry, the protection of the Australian Environment and the well-being of the Australian people. Key issues for this Centre include testicular cancer, male infertility, contraception, pest animal control, environmental impacts on human health and gene pharming.Read moreRead less
Building on rural knowledges to unlock the potential of rural students. This project aims to advance understanding of the distinctive knowledges that rural students bring to school and develop teaching practices that build on these rural knowledges to unlock the potential of this significant student population. The project involves collaborating with rural primary schools, teachers, students and communities to identify rural knowledges, study classroom practices in detail, and develop sustainabl ....Building on rural knowledges to unlock the potential of rural students. This project aims to advance understanding of the distinctive knowledges that rural students bring to school and develop teaching practices that build on these rural knowledges to unlock the potential of this significant student population. The project involves collaborating with rural primary schools, teachers, students and communities to identify rural knowledges, study classroom practices in detail, and develop sustainable teaching practices that help students connect rural knowledges and school knowledge. Expected outcomes include a framework of place-based teaching practices and resources that will benefit rural schooling, teacher education, and the education of communities crucial to the nation’s future wealth and welfare.Read moreRead less
Social, economic and health vulnerabilities in Indonesia. This project aims to study and provide ways to overcome vulnerability in Indonesia. Half the Indonesian population is still clustered around the poverty line, contributing to their vulnerability. This project will identify vulnerable groups and why they are vulnerable. Using a common framework of the life course in eight Indonesian field sites, this project will investigate whether social networks and welfare programs reduce vulnerability ....Social, economic and health vulnerabilities in Indonesia. This project aims to study and provide ways to overcome vulnerability in Indonesia. Half the Indonesian population is still clustered around the poverty line, contributing to their vulnerability. This project will identify vulnerable groups and why they are vulnerable. Using a common framework of the life course in eight Indonesian field sites, this project will investigate whether social networks and welfare programs reduce vulnerability, and pinpoint strategies for reducing vulnerabilities in the future. The project expects to show how vulnerable citizens in Indonesia can be made more secure, helping to build a more stable and prosperous region.Read moreRead less
Centre Of Research Excellence In Infectious Diseases Modelling To Inform Public Health Policy
Funder
National Health and Medical Research Council
Funding Amount
$2,600,064.00
Summary
Infectious diseases pose a global challenge, with substantial human and economic costs. Mathematical models provide valuable frameworks to assess likely benefits of interventions to control infection spread and burden. Leveraging existing NHMRC support, we will expand modeling capability to inform infectious disease control policy in Australia and our region. Focus areas include vaccine preventable disease, respiratory viruses and emerging pathogens, supported by innovative methods development.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0237729
Funder
Australian Research Council
Funding Amount
$735,000.00
Summary
A proteomics facility for Queensland researchers. The successful completion of sequencing of the genomes of many organisms, including man, has thrown emphasis back on the identification of proteins involved in the complex events that sustain cellular life. Our aim is to set up a world-class facility for proteomics research which will allow a large cohort of scientists at several institutions to identify individual proteins in vanishingly small samples of very complex mixtures. This facility wi ....A proteomics facility for Queensland researchers. The successful completion of sequencing of the genomes of many organisms, including man, has thrown emphasis back on the identification of proteins involved in the complex events that sustain cellular life. Our aim is to set up a world-class facility for proteomics research which will allow a large cohort of scientists at several institutions to identify individual proteins in vanishingly small samples of very complex mixtures. This facility will enable investigation of the control of gene expression, the intricate organisation of proteins within cells, and proteins which are potential drug targets. This equipment is an essential resource for Queensland research groups.Read moreRead less
More than a Roof Overhead: Meeting the Need for a Sustainable Housing System in Remote Indigenous Communities. Many Indigenous Australians live in substandard and over-crowded accommodation, and experience poor health, education, family stability and child-safety outcomes as a result. The lack of improvement in this situation is largely due to levels of funding and approaches to construction and management inadequate to the scale of the problem. This situation is changing and new funding and po ....More than a Roof Overhead: Meeting the Need for a Sustainable Housing System in Remote Indigenous Communities. Many Indigenous Australians live in substandard and over-crowded accommodation, and experience poor health, education, family stability and child-safety outcomes as a result. The lack of improvement in this situation is largely due to levels of funding and approaches to construction and management inadequate to the scale of the problem. This situation is changing and new funding and policies are being established. The researchers will work alongside housing providers and selected Indigenous communities in Western Australia and Northern Territory to develop procurement, construction and housing management practices that will meet the critical need for more affordable, appropriate and sustainable housing.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0454052
Funder
Australian Research Council
Funding Amount
$733,595.00
Summary
Tandem Matrix-Assisted Laser Desorption/Ionisation Time-Of-Flight Mass Spectrometer and Robots for High Throughput Proteomics Analysis. This proposal seeks to establish the capacity to perform high-energy tandem mass spectrometry on a high throughput basis, through purchase and coordinated operation of a Matrix-Assisted Laser Desorption/Ionisation - Time of Flight / Time of Flight - Mass Spectrometer and ancillary equipment, to enhance the proteomics expertise, infrastructure and research plans ....Tandem Matrix-Assisted Laser Desorption/Ionisation Time-Of-Flight Mass Spectrometer and Robots for High Throughput Proteomics Analysis. This proposal seeks to establish the capacity to perform high-energy tandem mass spectrometry on a high throughput basis, through purchase and coordinated operation of a Matrix-Assisted Laser Desorption/Ionisation - Time of Flight / Time of Flight - Mass Spectrometer and ancillary equipment, to enhance the proteomics expertise, infrastructure and research plans of a network of institutions from Queensland and New South Wales and their collaborators. Access to such instrumentation is critical to high level achievement in proteomics, a key platform technology for National Research Priorities relating to Frontier Technologies. No comparable instrument currently exists in Australia.Read moreRead less
Pharmacology Of Potential Anti-Tumour Agents: Iron Chelators Of The BpT Class
Funder
National Health and Medical Research Council
Funding Amount
$585,455.00
Summary
Pharmacology of Potential Anti-Tumour Agents: Iron Chelators of the BpT Class Cancer cells have a high iron requirement for DNA synthesis and many clinical trials showed Fe chelators are effective anti-cancer drugs. Their potential to act as anti-tumour agents has been confirmed by the entrance of Triapine into widespread NCI clinical trials. In this NHMRC Renewal, we will perform pharmacological and preclinical studies to promote the development of BpT chelators as novel anti-tumour agents.