A specialised set of T lymphocytes called Mucosal Associated Invariant T (MAIT) cells react against bacteria and yeast, and reside at mucosal sites where the body's immune defences are most easily breached, e.g. respiratory tract and intestinal mucosa. This study investigates the role of MAIT cells in both protection and pathology in bacterial infections. Controlling MAIT cells could help in treating these conditions.
Antigen Presentation, Recognition And The Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$14,927,045.00
Summary
This program focuses on understanding the development of immunity during infection or inflammatory diseases using a broad array of techniques to dissect the function of various immune cell types and to explore the relationship between structure and function of important cell surface molecules. These studies will improve our ability to design new generation vaccines for combating infectious diseases, controlling cancer, or limiting autoimmune or inflammatory diseases.
A Structural Investigation Into The T-cell Response To Epstein Barr Virus Infection
Funder
National Health and Medical Research Council
Funding Amount
$549,000.00
Summary
X-ray crystallography is an essential tool for solving the three-dimensional structure of proteins. Proteins control the biological processes within the cell and it is the precise shape of proteins that determines how they function. Depending on the particular sequence of the amino acids, the so-called building unit of the proteins, the protein molecule bends and forms a distinct, complex shape. This specific three-dimensional shape allows the protein to undertake its specific function, such as ....X-ray crystallography is an essential tool for solving the three-dimensional structure of proteins. Proteins control the biological processes within the cell and it is the precise shape of proteins that determines how they function. Depending on the particular sequence of the amino acids, the so-called building unit of the proteins, the protein molecule bends and forms a distinct, complex shape. This specific three-dimensional shape allows the protein to undertake its specific function, such as binding to other proteins, acting as an enzyme or interacting with nucleic acids. To determine how a protein acts, it is vital to know the precise three-dimensional shape at the atomic level. This proposal is concerned with understanding the precise shape of proteins that control the immune response to Epstein Barr Virus. Epstein Barr Virus is an ubiquitous human pathogen that has being linked to a number of cancers. This work will further our understanding of the immune response to Epstein Barr Virus.Read moreRead less
Antigen Presentation, Recognition And The Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$15,780,848.00
Summary
This program focuses on understanding the development of immune response to viruses and other infectious agents using a broad array of techniques to dissect the function of various immune cell types and to explore the relationship between structure and function of important cell surface molecules. These studies will improve our ability to design new generation vaccines for combating infectious diseases, controlling cancer, or limiting autoimmune diseases like diabetes.
Testing a new model for addressing covert racism faced by Indigenous youth . Racism is associated with poor mental health among Indigenous youth (14-25 years). Previous research has examined overt forms of racism but overlooked subtle and covert forms. This project is designed to provide crucial new knowledge on the forms, impacts, and interpersonal context of covert racism among Indigenous youth. We will adapt, to an Indigenous youth context, an international model of microaggressions (brief, d ....Testing a new model for addressing covert racism faced by Indigenous youth . Racism is associated with poor mental health among Indigenous youth (14-25 years). Previous research has examined overt forms of racism but overlooked subtle and covert forms. This project is designed to provide crucial new knowledge on the forms, impacts, and interpersonal context of covert racism among Indigenous youth. We will adapt, to an Indigenous youth context, an international model of microaggressions (brief, daily acts of covert racism) which focuses on the impacts of racism on targets and the roles of non-Indigenous peoples in either sustaining or ameliorating racism. Expected outcomes will be a new model of covert racism to inform future racism research and interventions in Australia and among other First Nations peoples. Read moreRead less
Re-uniting marsupials and eutherians by embryonic micromanipulation. The unique responsibility for transmitting life from generation to generation normally depends on the gametes. This project will use new reproductive technologies to investigate the properties of the oocyte in reprogramming somatic cell nuclei, and will use the nuclei of both marsupial and eutherian somatic cells to test this. We will also use both marsupial and eutherian genes to insert into the oocyte to create the first tra ....Re-uniting marsupials and eutherians by embryonic micromanipulation. The unique responsibility for transmitting life from generation to generation normally depends on the gametes. This project will use new reproductive technologies to investigate the properties of the oocyte in reprogramming somatic cell nuclei, and will use the nuclei of both marsupial and eutherian somatic cells to test this. We will also use both marsupial and eutherian genes to insert into the oocyte to create the first transgenic marsupials. We will also investigate the ability of spermatozoa from species of increasing genetic distance to ferttilise marsupial eggs using intracytoplasmic sperm injection (ICSI).Read moreRead less
An X-ray crystallographic investigation into co-receptors on T-lymphocytes. T lymphocytes are an indispensable cellular component of the immune system. The normal process of T cell selection in the thymus, and the ability of mature T cells to respond to foreign antigens are governed by receptor recognition and co-receptor mediated events. The co-receptors encompass a wide spectrum of structurally diverse proteins that are involved in adhesion, co-ligation and signal transduction. This proposa ....An X-ray crystallographic investigation into co-receptors on T-lymphocytes. T lymphocytes are an indispensable cellular component of the immune system. The normal process of T cell selection in the thymus, and the ability of mature T cells to respond to foreign antigens are governed by receptor recognition and co-receptor mediated events. The co-receptors encompass a wide spectrum of structurally diverse proteins that are involved in adhesion, co-ligation and signal transduction. This proposal aims to investigate, using X-ray crystallography as the primary research tool, co- receptors located on T-lymphocytes. This work will gain fundamental insights into co-receptor function.Read moreRead less
Healing Country: integrating knowledge systems to meet climate challenges. Aboriginal and Torres Strait Islander communities are currently experiencing severe environmental challenges related to a changing climate. Led by Aboriginal communities, this project aims to integrate traditional knowledges and environmental and health data to create community story-data maps. These interactive, online maps will be a unique and powerful blend of information, providing a rich evidence base, decision-suppo ....Healing Country: integrating knowledge systems to meet climate challenges. Aboriginal and Torres Strait Islander communities are currently experiencing severe environmental challenges related to a changing climate. Led by Aboriginal communities, this project aims to integrate traditional knowledges and environmental and health data to create community story-data maps. These interactive, online maps will be a unique and powerful blend of information, providing a rich evidence base, decision-support and communication tool to inform the co-design of local climate change mitigation, adaptation and resilience plans. The project aims to give agency to Aboriginal communities in leading a systems change process to reduce environmental risks and strengthen health and wellbeing.Read moreRead less
Assessing supportive care needs of Indigenous cancer survivors' caregivers. This project aims to gather data about the needs of partners and caregivers of Aboriginal and Torres Strait Islander cancer survivors. The project will undertake a comprehensive exploration of the experiences of caregivers and develop a psychometrically tested tool to assist in identifying unmet needs. The project expects to provide new knowledge about the needs of this population and a validated tool to better assess th ....Assessing supportive care needs of Indigenous cancer survivors' caregivers. This project aims to gather data about the needs of partners and caregivers of Aboriginal and Torres Strait Islander cancer survivors. The project will undertake a comprehensive exploration of the experiences of caregivers and develop a psychometrically tested tool to assist in identifying unmet needs. The project expects to provide new knowledge about the needs of this population and a validated tool to better assess these needs. The project will result in improvements in the assessment of unmet supportive care needs in caregivers of Indigenous cancer survivors, leading to more timely interventions, and a better quality of life for patients and caregivers.Read moreRead less