Exploiting the lymphatic system for next generation vaccine development . Vaccination is the most successful and cost-effective means of combating infectious diseases. This project will look at how vaccine adjuvants work and will help the development of new vaccines against infections in both animals and man. It will also promote the training of Australian scientists in the field of vaccine research and development.
Exploring the immunomodulatory potential of Natural Killer T cells. Natural Killer T cells (NKT cells) are an innate-like population of T cells that recognise a range of lipid based antigens when bound to the antigen-presenting molecule, CD1d. Once activated, NKT cells rapidly secrete a variety of cytokines. This project, in partnership with Vaxine Pty Ltd, aims to gain a basic understanding of NKT recognition of lipids and NKT cell activation by lipids. The project aims to use a combination of ....Exploring the immunomodulatory potential of Natural Killer T cells. Natural Killer T cells (NKT cells) are an innate-like population of T cells that recognise a range of lipid based antigens when bound to the antigen-presenting molecule, CD1d. Once activated, NKT cells rapidly secrete a variety of cytokines. This project, in partnership with Vaxine Pty Ltd, aims to gain a basic understanding of NKT recognition of lipids and NKT cell activation by lipids. The project aims to use a combination of cellular immunology and structural biology to gain insight into NKT cell agonism.Read moreRead less
Dissecting the physiology of multipotent mesenchymal stromal cells to develop vaccine candidates for respiratory disease. The project aims to gain an understanding of how a type of adult stem cell inhibits immune responses that cause asthma. The project will produce new stem cell products and facilitate the design of a vaccine for asthma and other respiratory diseases, which would greatly reduce the burden of such conditions.
Cellulosic and paper-based biosensors for blood analysis. Testing the blood compatibility of an Australian evacuated for surgery; measuring the iron content from India for anemia treatment; identifying the outbreak of malaria in Pakistan; measuring prostate specific antigen/blood screening in your home. These are novel applications for paper biosensors, which will improve health and create new jobs in Australia.
Biophysical identification of natural human antibody targets. A natural human antibody, PAT-SM6, isolated using technology developed by the partner organisation (Patrys), offers promise as a therapy to reduce mortalities due to cancer, the leading cause of death in Australia. The novelty of the approach pioneered by Patrys is the direct production of human antibodies which avoids undesirable side effects associated with the use of antibodies containing non-human components. This project is to ....Biophysical identification of natural human antibody targets. A natural human antibody, PAT-SM6, isolated using technology developed by the partner organisation (Patrys), offers promise as a therapy to reduce mortalities due to cancer, the leading cause of death in Australia. The novelty of the approach pioneered by Patrys is the direct production of human antibodies which avoids undesirable side effects associated with the use of antibodies containing non-human components. This project is to discover the specificity of PAT-SM6 for proteins and protein complexes and how these interactions lead to tumour cell death. This work will enhance the effectiveness of human antibody therapies and help in the development of this fast growing area within the biotechnology industry in Australia.Read moreRead less
Closing the gap on Indigenous birth registration. This project investigates the nature and extent of problems faced by Indigenous Australians trying to access the birth registration systems within Australia. Following extensive consultation with Indigenous communities and other key stakeholders, this project will identify the causes of the problem and recommend appropriate solutions.
Adult literacy and Aboriginal community well-being in western NSW. Adult literacy and Aboriginal community well-being in western NSW. This project aims to examine the effect of an adult literacy campaign on Aboriginal communities in New South Wales. Since 2012, four western NSW Aboriginal communities have implemented a Cuban-designed mass campaign model to address very low levels of adult literacy. Over 100 people will have achieved basic literacy by July 2016, and four more communities will joi ....Adult literacy and Aboriginal community well-being in western NSW. Adult literacy and Aboriginal community well-being in western NSW. This project aims to examine the effect of an adult literacy campaign on Aboriginal communities in New South Wales. Since 2012, four western NSW Aboriginal communities have implemented a Cuban-designed mass campaign model to address very low levels of adult literacy. Over 100 people will have achieved basic literacy by July 2016, and four more communities will join by 2019. This project will use a social determinants of health framework to analyse quantitative and qualitative data collected at an individual and population level. This research is expected to improve understanding of the link between Aboriginal adult literacy and health.Read moreRead less
Functional characterisation of neurons derived from embryonic stem cells and NS cells. The ability to obtain specific neurons from NS cells will revolutionise the study of nerve function, will allow the establishment of much-improved models for discovery of new drugs, and will define how enriched populations of neural cells can be obtained for applications in treatment of neurodegenerative diseases. The project will provide vital data for the emerging biotechnology industry associated will appl ....Functional characterisation of neurons derived from embryonic stem cells and NS cells. The ability to obtain specific neurons from NS cells will revolutionise the study of nerve function, will allow the establishment of much-improved models for discovery of new drugs, and will define how enriched populations of neural cells can be obtained for applications in treatment of neurodegenerative diseases. The project will provide vital data for the emerging biotechnology industry associated will applications of stem cell biology, and will stimulate clinical researchers to investigate the therapeutic potential of cell derived from NS cells.Read moreRead less
Intracellular trafficking and function of a recycling receptor which prolongs the serum half-life of novel therapeutic proteins. The life span of recombinant engineered proteins for therapeutic use is a critical factor in their effectiveness, ease of clinical application and cost. This project will exploit interactions with a natural receptor, which prolongs the lifespan of serum proteins, to enhance survival of therapeutic engineered proteins.
How Meston's 'Wild Australia Show' shaped Australian Aboriginal history. How Meston's 'Wild Australia Show' shaped Australian Aboriginal history. This project aims to produce an authoritative and original interpretation of the Wild Australia Show (1892–93), staged by a diverse company of Aboriginal people for metropolitan audiences. The Show will be the focus of an interdisciplinary study of performance, photography, collections and race relations in colonial Australia, using archival and visual ....How Meston's 'Wild Australia Show' shaped Australian Aboriginal history. How Meston's 'Wild Australia Show' shaped Australian Aboriginal history. This project aims to produce an authoritative and original interpretation of the Wild Australia Show (1892–93), staged by a diverse company of Aboriginal people for metropolitan audiences. The Show will be the focus of an interdisciplinary study of performance, photography, collections and race relations in colonial Australia, using archival and visual records. The project will situate the Show in local, national and transnational narratives informed by contemporary Indigenous perspectives. This research should illuminate Aboriginal agency in the ensemble, reconnect Aboriginal kin to performers, and chart changing concepts of race at a critical juncture in Australian history.Read moreRead less