How Does NF-kB2 Regulate Thymic Selection To Prevent Organ-specific Autoimmune Disease?
Funder
National Health and Medical Research Council
Funding Amount
$787,600.00
Summary
Autoimmune diseases like type 1 diabetes and thyroiditis arise from defects that cause the immune system to confuse self and non-self. Normally, this distinction is programmed in the thymus. We recently identified the gene that causes a form of autoimmune disease. We also made an important discovery about how the thymus gland regulates self-non-self discrimination. We will build on these two discoveries to gain a precise understanding of how the immune system normally avoids autoimmune disease.
Modeling Human Actin Related Protein 2/3 Complex Subunit 1B (ARPC1B) Deficiency In Mice
Funder
National Health and Medical Research Council
Funding Amount
$755,005.00
Summary
The actin cytoskeleton forms the structure that not only keeps cells in their normal shape but is also essential for the movement of cells and for interaction between cells. We have recently identified the first patients with an immunodeficiency caused by a defect in a gene called ARPC1B, which plays a crucial role in the regulation of actin. Through the investigation of novel mouse models we will elucidate the pathomechanism underlying the disease of these patients.
It is feasible to sequence patient genomes but we need to know more about how genetic variants cause complex disease. We have sequenced genomes from patients with immune deficiency and will test the idea that genetic variation causes consistent changes in particular white blood cells, thus providing a bridge between genomic information and clinical diagnosis. Outcomes will include more accurate diagnosis, better understanding of immunity, and a strategy for using whole genome information.
Methylation-sensitive T Cell Genes And Childhood Food Allergy.
Funder
National Health and Medical Research Council
Funding Amount
$461,232.00
Summary
Australia has the highest reported prevalence food allergy in the world. Despite this, little is known about how allergy develops. Mounting evidence implicates environmentally induced disruption of the genetic blueprint via a process known as epigenetics. We are combining the strengths of food challenge proven food allergy with assessment of immune functioning & cutting edge genomics, to extensively characterise the pathways leading to food allergy in children.
Understanding The Pathogenesis And Heterogeneity Of Autoimmunity As Failure Of Multiple Steps
Funder
National Health and Medical Research Council
Funding Amount
$504,023.00
Summary
Autoimmune diseases like diabetes, thyroid disease or rheumatoid arthritis affect around 1 in 15 people in Australia. It is clear that defects in a number of different genetic mechanisms can contribute to the development of autoimmunity. But it is currently not clear how these different mechanisms need to interact to prevent the onset of disease. This grant seeks to understand these interactions and how defects in two or more tolerance mechanisms can lead to autoimmunity.
Methylation Sensitive Genes And The Transition To Allergic Disease: A Twin Study
Funder
National Health and Medical Research Council
Funding Amount
$493,843.00
Summary
Australia has amongst the highest reported prevalence allergic conditions (including asthma) in the world. Despite this, little is known about how these conditions arise. Mounting evidence implicates environmentally induced disruption of the genetic blueprint via a process known as epigenetics. We are combining the strengths of a unique collection of identical twins where one of a pair is sensitive to house dust mite, with cutting edge genomics, to characterise the pathways leading to allergy in ....Australia has amongst the highest reported prevalence allergic conditions (including asthma) in the world. Despite this, little is known about how these conditions arise. Mounting evidence implicates environmentally induced disruption of the genetic blueprint via a process known as epigenetics. We are combining the strengths of a unique collection of identical twins where one of a pair is sensitive to house dust mite, with cutting edge genomics, to characterise the pathways leading to allergy in children.Read moreRead less
Yarning with our mob about human papillomavirus (HPV) vaccination uptake. This project aims to identify a range of modifiable factors that affect the participation of Indigenous adolescents in human papillomavirus (HPV) vaccination school programs. The project expects to generate new knowledge by combining Indigenous methodologies and a socioecological model to explore policy, community, interpersonal and intrapersonal factors impacting HPV vaccination uptake for this population. Expected outcom ....Yarning with our mob about human papillomavirus (HPV) vaccination uptake. This project aims to identify a range of modifiable factors that affect the participation of Indigenous adolescents in human papillomavirus (HPV) vaccination school programs. The project expects to generate new knowledge by combining Indigenous methodologies and a socioecological model to explore policy, community, interpersonal and intrapersonal factors impacting HPV vaccination uptake for this population. Expected outcomes include a more comprehensive understanding of the factors behind the low rates of HPV vaccination among Indigenous adolescents. This information should provide significant benefits including the identification of modifiable factors to increase HPV vaccination rates for Indigenous adolescents.Read moreRead less
Co-designing a Food Sovereignty Model with Indigenous Communities. Food sovereignty asserts the rights of people and communities to healthy and culturally appropriate foods through determination of their own food and agriculture systems. With food insecurity higher among Indigenous households; a food sovereignty approach offers the potential for sustainable long-term solutions that maintain human dignity and reinvigorate knowledge systems. Drawing on national and international perspectives and u ....Co-designing a Food Sovereignty Model with Indigenous Communities. Food sovereignty asserts the rights of people and communities to healthy and culturally appropriate foods through determination of their own food and agriculture systems. With food insecurity higher among Indigenous households; a food sovereignty approach offers the potential for sustainable long-term solutions that maintain human dignity and reinvigorate knowledge systems. Drawing on national and international perspectives and using Indigenous research methodologies, this project aims to co-design a food sovereignty model that will enable Indigenous communities to effectively address food insecurity according to their local contexts. Both the process and solutions will contribute to improvements in physical, mental and social wellbeing.Read moreRead less
Historical frontier violence: drivers, legacy and the role of truth-telling. This project aims to build data to identify the historical factors that incited frontier violence; quantify the legacy on communities today and conduct fieldwork to understand how historical trauma is transmitted across generations. This project expects to develop new knowledge on the circumstances and legacy of settlement and the origins of gaps in life prospects between Indigenous and non-Indigenous Australians. Our e ....Historical frontier violence: drivers, legacy and the role of truth-telling. This project aims to build data to identify the historical factors that incited frontier violence; quantify the legacy on communities today and conduct fieldwork to understand how historical trauma is transmitted across generations. This project expects to develop new knowledge on the circumstances and legacy of settlement and the origins of gaps in life prospects between Indigenous and non-Indigenous Australians. Our expectation is that this will increase public acceptance of the circumstances of settlement and the need to make amends. This project should help increase public support for truth-telling and better relations between Indigenous and non-Indigenous Australians, a vital step towards reconciliation and healing the nation. Read moreRead less