Identifying The Critical Pathways Which Regulate Vertebrate Craniofacial Development
Funder
National Health and Medical Research Council
Funding Amount
$552,131.00
Summary
Understanding the genes which underlie human birth defects is of immense clinical importance. Our laboratory is a world-leader investigating a gene responsible for facial skeleton development, Grhl2. With our wide range of models, we will discover how Grhl2 works to ensure the face and skull develop properly during birth.
Understanding The Causes Of Childhood Congenital Anomalies Of The Kidney And Urinary Tract
Funder
National Health and Medical Research Council
Funding Amount
$609,748.00
Summary
Congenital anomalies of the kidney and urinary tract (CAKUT) is a common cause of renal failure in children. The majority of patients with CAKUT do not know the underlying cause of their renal anomalies. In this proposal we will characterise the developmental events that are perturbed in three mouse models of CAKUT and identify the causal gene responsible in each mouse model. We will translate this information to the clinic by screening patients with CAKUT for mutations in these newly identified ....Congenital anomalies of the kidney and urinary tract (CAKUT) is a common cause of renal failure in children. The majority of patients with CAKUT do not know the underlying cause of their renal anomalies. In this proposal we will characterise the developmental events that are perturbed in three mouse models of CAKUT and identify the causal gene responsible in each mouse model. We will translate this information to the clinic by screening patients with CAKUT for mutations in these newly identified genes.Read moreRead less
Special Research Initiatives - Grant ID: SR0354693
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Australian e-Research Grid. The e-Research Grid program will research and implement core Grid technologies on APAC and partner's deployed HPC resources, to underpin a broad range of Australian research. The computer science CIs will form collaborative links with international programs, adapting developments to local circumstances. The applications-domain CIs will leverage those into their scientific simulations and databases, using grid integrative techniques and portals. Many CIs participate in ....Australian e-Research Grid. The e-Research Grid program will research and implement core Grid technologies on APAC and partner's deployed HPC resources, to underpin a broad range of Australian research. The computer science CIs will form collaborative links with international programs, adapting developments to local circumstances. The applications-domain CIs will leverage those into their scientific simulations and databases, using grid integrative techniques and portals. Many CIs participate in other RNs linking to their motivating applications, enhancing prospects for research and integration. They participate in the APAC Grid program, leveraging 75 HPC staff nationally. A key aim is interoperability with "real-world Grids": eg e-learning & e-health programs.Read moreRead less
ARC Research Network in Enterprise Information Infrastructure. EII targets consolidated research towards the comprehensive development & establishment of advanced information infrastructures. Its prime purpose is to provide a forum for intellectual exchange by diverse yet complementary research groups, to address the fundamental research problems faced by scientific & business communities when dealing with deployment of information technology to globally distributed, and data intensive environme ....ARC Research Network in Enterprise Information Infrastructure. EII targets consolidated research towards the comprehensive development & establishment of advanced information infrastructures. Its prime purpose is to provide a forum for intellectual exchange by diverse yet complementary research groups, to address the fundamental research problems faced by scientific & business communities when dealing with deployment of information technology to globally distributed, and data intensive environments. EII will address 3 tightly coupled research themes: Ability to interoperate across existing heterogenous platforms & applications; Efficient processing of very large data sets; Technology adoption & impact. Generic results will be applicable to e-science and large business information systems installations.Read moreRead less
Building Australia's next-generation ocean-sea ice model. Ocean and sea ice models are used for predicting future ocean and climate states, and for climate process research. This project aims to bring the next generation of ocean-sea ice models to Australia and configure the models for our local priorities. The ultimate goal is to create a new coupled ocean-sea ice model for Australia that includes surface waves and biogeochemistry. The model will be optimised and evaluated on Australian facilit ....Building Australia's next-generation ocean-sea ice model. Ocean and sea ice models are used for predicting future ocean and climate states, and for climate process research. This project aims to bring the next generation of ocean-sea ice models to Australia and configure the models for our local priorities. The ultimate goal is to create a new coupled ocean-sea ice model for Australia that includes surface waves and biogeochemistry. The model will be optimised and evaluated on Australian facilities, and released for community use. These developments underpin future ocean state forecasts, sea ice forecasts, wave forecasts, decadal climate prediction and climate process studies. The project will benefit search and rescue, Defence and shipping operations, and will enhance future climate projections.Read moreRead less
Population ageing, labour mobility and sustainability of China's economic growth - a dynamic general equilibrium analysis. China is Australia's second largest trading partner. This project will enable Australian policymakers and business partners to gain better understanding of China's macroeconomic performance between 2008 and 2030. Secondly, China is the second largest source of immigrants to Australia. Given that Australia's population is ageing and labour shortages are expected, Australia ma ....Population ageing, labour mobility and sustainability of China's economic growth - a dynamic general equilibrium analysis. China is Australia's second largest trading partner. This project will enable Australian policymakers and business partners to gain better understanding of China's macroeconomic performance between 2008 and 2030. Secondly, China is the second largest source of immigrants to Australia. Given that Australia's population is ageing and labour shortages are expected, Australia may benefit increasingly from the flow of Chinese immigrants. The project will provide Australian policymakers with detailed labour supply forecasts in China disaggregated by age, sex, sector and region that will enable them to develop targeted immigration policies and effectively harness the flow of Chinese emigrants to Australia.Read moreRead less
Fault detection and identification in nonlinear complex systems. Complex systems usually comprise a large number of inter-dependent subsystems linked together to perform a certain task. Examples of such systems are power systems, irrigation systems, air traffic control systems, to name a few. Such systems are subject to component failure or malfunction. Total failure can cause an unacceptable financial losses and/or danger to personnel. It is therefore extremely essential, from economic and safe ....Fault detection and identification in nonlinear complex systems. Complex systems usually comprise a large number of inter-dependent subsystems linked together to perform a certain task. Examples of such systems are power systems, irrigation systems, air traffic control systems, to name a few. Such systems are subject to component failure or malfunction. Total failure can cause an unacceptable financial losses and/or danger to personnel. It is therefore extremely essential, from economic and safety view points, that a way be found to ensure reliable and viable operation of complex plants. A first step in achieving this goal is to detect faults on-line and in real-time when they occur and identify their location and characteristics, which is the aim of this project.Read moreRead less
New estimation and testing issues in nonlinear time series econometrics. The outcomes of this project will not only complement but also enhance the existing strengths of Australian researchers in the field of econometrics. The outcomes are also expected to help stabilise the national financial market for more accurate forecasts. It is also expected that the outcomes will provide novel models to respond to climate change and variability and to provide accurate warming estimates for improving the ....New estimation and testing issues in nonlinear time series econometrics. The outcomes of this project will not only complement but also enhance the existing strengths of Australian researchers in the field of econometrics. The outcomes are also expected to help stabilise the national financial market for more accurate forecasts. It is also expected that the outcomes will provide novel models to respond to climate change and variability and to provide accurate warming estimates for improving the policy making process.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100116
Funder
Australian Research Council
Funding Amount
$1,200,000.00
Summary
Facilities for Atmospheric Boundary Layer Evaluation and Testing. This proposal aims to establish state-of-the-art stationary and mobile facilities for atmospheric wind, dust and plume measurements with unique capability to quantify the effect of climate change, surface topography and urbanisation on near-surface microclimate where humans live. To better predict microclimate, mitigate air pollution impacts and exploit local conditions for improved urban planning and agricultural yield, high qual ....Facilities for Atmospheric Boundary Layer Evaluation and Testing. This proposal aims to establish state-of-the-art stationary and mobile facilities for atmospheric wind, dust and plume measurements with unique capability to quantify the effect of climate change, surface topography and urbanisation on near-surface microclimate where humans live. To better predict microclimate, mitigate air pollution impacts and exploit local conditions for improved urban planning and agricultural yield, high quality observations of the near-surface atmosphere at fine temporal and spatial resolutions are required. The proposed Facilities for Atmospheric Boundary Layer Evaluation and Testing (FABLET) will advance Australia’s capability to make these difficult measurements of atmospheric boundary layer.Read moreRead less
Empowering next-generation sea-ice models with wave–ice mathematics. Sea ice is a crucial part of the Australian and global climate systems, and the most sensitive indicator of the alarming climate changes in motion. This project aims to deliver a vital component in next-generation sea-ice models, by modelling ocean waves in the ice-covered ocean, and implementing it in the leading large-scale sea-ice model. The waves-in-ice model will be accurate for the range of possible wave–ice conditions, u ....Empowering next-generation sea-ice models with wave–ice mathematics. Sea ice is a crucial part of the Australian and global climate systems, and the most sensitive indicator of the alarming climate changes in motion. This project aims to deliver a vital component in next-generation sea-ice models, by modelling ocean waves in the ice-covered ocean, and implementing it in the leading large-scale sea-ice model. The waves-in-ice model will be accurate for the range of possible wave–ice conditions, using understanding derived from state-of-the-art experimental measurements. Powerful mathematical approximation methods will be developed to generate model efficiency. The outcomes will create a new standard in sea-ice modelling, with significant benefits for sea-ice forecasting and climate studies.Read moreRead less