Induction Of Islet Transplant Tolerance In A Humanised Mouse Model
Funder
National Health and Medical Research Council
Funding Amount
$374,552.00
Summary
The current treatment for type 1 diabetes (T1D) is insulin therapy, but it cannot fully prevent chronic complications. Also intensive insulin use increases the risk of fatal hypoglycemia. An emerging therapy which may overcome or at least reduce these problems is the transplantation of human islet cells. But preventing the immune system from rejecting these cell transplants is still a major challenge. This study will develop new therapeutic strategies to protect these transplants from rejection.
A New Approach To The Design And Evaluation Of T Cell Vaccines For Cancer And Infectious Disease.
Funder
National Health and Medical Research Council
Funding Amount
$394,137.00
Summary
Special white blood cells called dendritic cells teach the immune system to fight cancer and are a key component of therapeutic cancer vaccines. We identified a subtype of human dendritic cell that is predicted to be the most effective at mounting anti-cancer immune responses. We developed a novel antibody specific for these dendritic cells that can be used to deliver the vaccine directly to them and will use this to construct and validate a novel vaccine for cancer and viral infections.
Modelling and Performance Evaluation of Stab and Ballistic Resistant Fabrics. The aims of the project are to model and design stab resistant fabrics, and evaluate their stab and ballistic performance under simulated end-use conditions. Bi-component ballistic and stab resistant wearable and concealable garments will be produced and comprehensively characterised. This program is a significant first step towards developing Australian owned intellectual property for specialised protective garments f ....Modelling and Performance Evaluation of Stab and Ballistic Resistant Fabrics. The aims of the project are to model and design stab resistant fabrics, and evaluate their stab and ballistic performance under simulated end-use conditions. Bi-component ballistic and stab resistant wearable and concealable garments will be produced and comprehensively characterised. This program is a significant first step towards developing Australian owned intellectual property for specialised protective garments for local and export markets. Results from this study will produce fundamental knowledge on stab and ballistic resistant fabrics and armours, and provide practical information on the preparation of commercially acceptable protective products.Read moreRead less