Exploring new roles for phosphorus radicals in health, environment, and technology. Several practical outcomes will arise from this project. Information on processes that contribute to genetic disease and cancer will be derived through studies of the role of phosphorus radicals in DNA damage. Processes that lead to the degradation of natural and synthetic materials in the environment will be explored. Clean reactions will be developed for the fabrication of advanced materials (e.g. pharmaceutica ....Exploring new roles for phosphorus radicals in health, environment, and technology. Several practical outcomes will arise from this project. Information on processes that contribute to genetic disease and cancer will be derived through studies of the role of phosphorus radicals in DNA damage. Processes that lead to the degradation of natural and synthetic materials in the environment will be explored. Clean reactions will be developed for the fabrication of advanced materials (e.g. pharmaceuticals). These innovations will expand Australia's international profile in a growing research area. The project will also address three of Australia's National Research Priorities, contribute to the training of researchers in Free Radical Chemistry, and initiate research collaborations with institutions in France and the USA.Read moreRead less
Atmospheric Free-Radicals: Exploring the Role of Nitrate Radicals in the Oxidative Damage of Bio-Surfaces. This project falls within the National Research Priority 2 (Promoting and Maintaining Good Health) as identified by the ARC, specifically Priority Goal 2 (Ageing well, ageing productively) and Priority Goal 3 (Preventive healthcare). The study will lead to a better understanding of environmental factors influencing health and welfare of Australians every age and will provide unique opport ....Atmospheric Free-Radicals: Exploring the Role of Nitrate Radicals in the Oxidative Damage of Bio-Surfaces. This project falls within the National Research Priority 2 (Promoting and Maintaining Good Health) as identified by the ARC, specifically Priority Goal 2 (Ageing well, ageing productively) and Priority Goal 3 (Preventive healthcare). The study will lead to a better understanding of environmental factors influencing health and welfare of Australians every age and will provide unique opportunities for students to be trained in cutting-edge basic research. Knowledge and fundamental understanding of the damage of bio-surfaces caused by atmospheric free-radical oxidants and their potential role in ageing processes will help to develop novel medical strategies, which substantially contribute to the quality of Australian sciences.Read moreRead less
Exploring the Frontiers of Free-Radical Chemistry: Self-Terminating Radical Reactions. Self-terminating free-radical reactions are a new concept in the chemist's synthetic armory. This innovative technique, invented by the chief investigators, has enormous synthetic scope that is yet largely untapped. This proposal seeks to develop novel reactions based on this concept; to explore their generality and versatility in organic synthesis through the use of both laboratory and computational techniq ....Exploring the Frontiers of Free-Radical Chemistry: Self-Terminating Radical Reactions. Self-terminating free-radical reactions are a new concept in the chemist's synthetic armory. This innovative technique, invented by the chief investigators, has enormous synthetic scope that is yet largely untapped. This proposal seeks to develop novel reactions based on this concept; to explore their generality and versatility in organic synthesis through the use of both laboratory and computational techniques. In this manner, singificant contributions to frontier technologies and breakthrough science will be made.Read moreRead less
C-H to C-F using electrochemistry and gold catalysis. Gold offers great potential in chemical catalysis and this project will use a fascinating new class of gold compounds discovered by the CIs, to develop novel catalysts. Using this chemistry a series of gold(III) compounds with fluoride ligands will be prepared. The catalytic properties of these molecules will then be explored, with a particular focus on adding value to arene hydrocarbons. The ultimate goal of the project is development of new ....C-H to C-F using electrochemistry and gold catalysis. Gold offers great potential in chemical catalysis and this project will use a fascinating new class of gold compounds discovered by the CIs, to develop novel catalysts. Using this chemistry a series of gold(III) compounds with fluoride ligands will be prepared. The catalytic properties of these molecules will then be explored, with a particular focus on adding value to arene hydrocarbons. The ultimate goal of the project is development of new catalysts for the formation of carbon-fluorine bonds and the selective fluorination of organic
compounds. Fluorinated organic molecules are of critical importance in medicinal chemistry and new catalysts of this type offers the potential for better synthesis of medicines and diagnostic agents.Read moreRead less
Chiral Catalysts by Rational Design. This project aims to integrate theory and experiment to design new catalysts for the synthesis of multi-stereocentre-containing molecules. Such molecules offer clear advantages in the area of drug design, owing to their potent and selective binding to biological targets, but a lack of available methods for their preparation currently limits their widespread use. This project will use theory to guide the discovery of new ways to make these molecules. It is exp ....Chiral Catalysts by Rational Design. This project aims to integrate theory and experiment to design new catalysts for the synthesis of multi-stereocentre-containing molecules. Such molecules offer clear advantages in the area of drug design, owing to their potent and selective binding to biological targets, but a lack of available methods for their preparation currently limits their widespread use. This project will use theory to guide the discovery of new ways to make these molecules. It is expected that detailed understanding of the factors that control stereocentre formation will be obtained from accurate theoretical modelling and will be applied to invent new catalysts that deliver improved performance and control over product structure.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100100
Funder
Australian Research Council
Funding Amount
$975,934.00
Summary
Multifunctional Platform for Chemical Manufacturing and Energy Materials. We aim to establish the first platform in Australia for the continuous production and in-situ characterisation of molecules and nanomaterials. This project expects to generate new knowledge in the area of functional materials using an interdisciplinary approach. The expected outcomes will be a unique analytical capability for rapid screening of synthetic and operational parameters, and unprecedented fundamental insight int ....Multifunctional Platform for Chemical Manufacturing and Energy Materials. We aim to establish the first platform in Australia for the continuous production and in-situ characterisation of molecules and nanomaterials. This project expects to generate new knowledge in the area of functional materials using an interdisciplinary approach. The expected outcomes will be a unique analytical capability for rapid screening of synthetic and operational parameters, and unprecedented fundamental insight into chemical reactions to inform the design and development of sustainable chemical processes. This proposal will provide significant benefits to cutting-edge research in catalysis, polymer engineering, separation science, CO2 capture and organic synthesis, to positively impact on the energy-manufacturing-environment nexus.Read moreRead less
Study the Utility of Novel Drug Polymer Conjugates. The products likely to arise from the technology described in this proposal could have application in medical, veterinary and agricultural industries. It offers the potential to treat diseases that are at present poorly treated by enabling delivery direct to the diseased organ (e.g. eye - bacterial endophthalmitis). Completion of the project will also assist a fledgling biotech company transition to a development company with a multiple produ ....Study the Utility of Novel Drug Polymer Conjugates. The products likely to arise from the technology described in this proposal could have application in medical, veterinary and agricultural industries. It offers the potential to treat diseases that are at present poorly treated by enabling delivery direct to the diseased organ (e.g. eye - bacterial endophthalmitis). Completion of the project will also assist a fledgling biotech company transition to a development company with a multiple product portfolio, which will have a direct economic benefit to Australia both in terms of potential export earnings and as an employer highly skilled staff. The project will also provide research training and career opportunities for developing Australian based researchers.Read moreRead less