Noradrenaline Transporter Dysfunction In Neural Circulatory Disorders: Clinical, Molecular And Therapeutic Implications
Funder
National Health and Medical Research Council
Funding Amount
$510,870.00
Summary
We will investigate the clinical relevance of noradrenaline transporter (NET) dysfunction and its molecular and genetic regulation in (1) essential hypertension, (2) postural tachycardia syndrome where the heart rate increases abnormally when the patient assumes an upright position and (3) syncope where subjects experience recurrent blackouts. In a therapeutic approach, we will explore whether NET inhibition can reduce the number of episodes and alleviate the symptoms associated with syncope.
Understanding The Role Of Supracollicular Nuclei In The Generation Of Basal Sympathetic Vasomotor Tone.
Funder
National Health and Medical Research Council
Funding Amount
$238,500.00
Summary
Increased activity from the parts of the brain which regulate blood pressure is observed in patients with cardiovascular diseases, including high blood pressure and heart failure. In some cases this increased activity might actually cause the high blood pressure. In all cases this increased activity can lead to serious complications including arrhythmias of the heart, enlargement of the heart and blood vessels, and even sudden cardiac death. This project aims to understand in more detail the par ....Increased activity from the parts of the brain which regulate blood pressure is observed in patients with cardiovascular diseases, including high blood pressure and heart failure. In some cases this increased activity might actually cause the high blood pressure. In all cases this increased activity can lead to serious complications including arrhythmias of the heart, enlargement of the heart and blood vessels, and even sudden cardiac death. This project aims to understand in more detail the parts of the brain that generate this activity. This information will enable more selective and effective treatments to be developed for people with high blood pressure or heart failure.Read moreRead less