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An International Population-Based Study Into The Genetic Epidemiology Of Melanoma
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
Melanoma is the most aggressive form of skin cancer and is a major public health issue in Australia. This project aims to find genes and levels of sun exposure, plus ways the genes and exposure interact with each other, that increase people’s risk of melanoma and how long they survive after diagnosis. The results will help to identify people at a higher risk of disease earlier and also better predict prognosis in those already diagnosed.
Causes Of Multiple Sclerosis: A Functional Genomics Approach
Funder
National Health and Medical Research Council
Funding Amount
$311,860.00
Summary
Multiple sclerosis (MS) is a chronic disease that damages the brain and spinal cord and can cause, numbness, muscle weakness, difficulties with coordination and balance, problems with speech and swallowing, visual problems, fatigue and bladder and bowel difficulties. After a world-wide effort, a large number of multiple sclerosis genes have been localized in the human genome. This project examines three of these in detail aiming to identify exactly how they contribute to the risk of developing M ....Multiple sclerosis (MS) is a chronic disease that damages the brain and spinal cord and can cause, numbness, muscle weakness, difficulties with coordination and balance, problems with speech and swallowing, visual problems, fatigue and bladder and bowel difficulties. After a world-wide effort, a large number of multiple sclerosis genes have been localized in the human genome. This project examines three of these in detail aiming to identify exactly how they contribute to the risk of developing MSRead moreRead less
Using Next-generation Sequencing Technology To Identify Genetic Determinants Of Epilepsy And Sporadic Epilepsy Prognosis
Funder
National Health and Medical Research Council
Funding Amount
$322,282.00
Summary
Recent advances in high-throughput, next-generation, DNA sequencing allows biologists to simultaneously analyse the differences in thousands of different genes across affected and unaffected individuals. However, it produces an overwhelming amount of data and making sense of this deluge of data is a current challenge. Overcoming this challenge will enable scientific discoveries of pathogenic variants of disease, potentially providing an opportunity for targeted drug development.
A Piggy-back Screen For Genes Involved In Cancer Epigenetics
Funder
National Health and Medical Research Council
Funding Amount
$302,123.00
Summary
Cancer can be caused not only by mutations in genes, but also by changes to our epigenome, which controls whether genes are on or off. There is much still to learn about the epigenome. We have developed a method to identify epigenome regulators. The epigenome is disrupted in cancer, but it is not know whether this starts tumour growth. I will use mutant mice to study this and analyse human cancers for mutations in epigenome regulators. This may lead to preventative screening and new treatments.