An International Population-Based Study Into The Genetic Epidemiology Of Melanoma
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
Melanoma is the most aggressive form of skin cancer and is a major public health issue in Australia. This project aims to find genes and levels of sun exposure, plus ways the genes and exposure interact with each other, that increase people’s risk of melanoma and how long they survive after diagnosis. The results will help to identify people at a higher risk of disease earlier and also better predict prognosis in those already diagnosed.
Who To Treat, When To Treat And How To Treat Prostate Cancer: Generating Evidence To Guide Prostate Cancer Treatment Decisions
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
There is considerable uncertainty about which treatments lead to better outcomes for men with prostate cancer and whether treatment is always necessary. This project will compare different treatment options for prostate cancer, including active surveillance, to determine which offers the best chance of survival and least harm to men’s physical and mental wellbeing. It will also explore whether some men who do not receive active treatment (healthy older men) would benefit if they did.
T-cells: The Key To Unlocking Immunity Against Aggressive Lymphoma
Funder
National Health and Medical Research Council
Funding Amount
$322,951.00
Summary
By investigating several aspects of patients’ immune defenses against the cancer cells in Diffuse large B-cell lymphoma, this project will provide critical insights on ways to harness the patient’s own immune system to effectively mount anti-tumour responses. These results will pave the way for future therapeutic strategies to successfully treat and prevent lymphoma.
A Genome Wide Screen For Human Genes That Support The Replication Of Intracellular Bacterial Pathogens
Funder
National Health and Medical Research Council
Funding Amount
$321,090.00
Summary
Coxiella burnetii is a bacterium that causes a life threatening infection of humans, termed Q fever.Coxiella survives and replicates inside human cells within a unique protected niche and little is known about how the bacterium does this. This study will identify and investigate the individual human proteins that are used by the bacterium to manipulate the human cells it inhabits and the mechanisms through which the bacterium achieves this.
Dissecting BAFF Receptor Signals: Key Mediators Of B-Lymphocyte Survival And Autoimmune Disease
Funder
National Health and Medical Research Council
Funding Amount
$376,165.00
Summary
B-Cells of the immune system need a growth factor named 'BAFF' to grow and survive. Elevated levels of BAFF have been detected in patients suffering from autoimmune diseases like lupus and arthritis, and B-Cell cancers like myeloma. This study will determine the identity of the chemical messages that BAFF sends to B-Cells, and how these facilitate B-Cell growth and survival. This will provide a framework for the design of targeted drug therapies that reduce the severity of BAFF related diseases.
Evaluating Neonatal And Child Health Interventions For Evidence Based Planning And Practice In Low Resourced Countries
Funder
National Health and Medical Research Council
Funding Amount
$410,512.00
Summary
The overall aim is to develop a neonatal and child health research programme responding to the various needs of resource poor country governments and provide an evidence base for public and clinical interventions and health programming. One neonatal study is outlined evaluating alternative phototherapy treatment for neonatal jaundice.