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Individualising Care For Patients With Chronic Hepatitis C: Predicting Side Effects And Treatment Response Using Genomic And Proteomic Approaches.
Funder
National Health and Medical Research Council
Funding Amount
$55,575.00
Summary
Patients undergoing treatment for hepatitis C must endure a treatment characterized by unpredictable treatment side effects and uncertainty about the likelihood of cure. This project will investigate genetic predictors of treatment related side-effects and protein markers to predict treatment response. Better definition of the risks and benefits of therapy, may facilitate patients and clinicians to make more informed decisions about treatment, thus individualising treatment and potentially impro ....Patients undergoing treatment for hepatitis C must endure a treatment characterized by unpredictable treatment side effects and uncertainty about the likelihood of cure. This project will investigate genetic predictors of treatment related side-effects and protein markers to predict treatment response. Better definition of the risks and benefits of therapy, may facilitate patients and clinicians to make more informed decisions about treatment, thus individualising treatment and potentially improving the safety and efficacy of therapy.Read moreRead less
Chronic Kidney Disease: Natural History Of Disease, Cost And Quality Of Life
Funder
National Health and Medical Research Council
Funding Amount
$72,281.00
Summary
Chronic kidney disease (CKD) is present in 12% of Australians aged over 25. CKD is associated with poor health outcomes including cardiovascular disease and progression to End Stage Kidney Disease. Many questions about CKD remain. My research aims to increase our understanding of the natural history of CKD in the Australian population, with focus on outcomes of CKD progression, cardiovascular and all-cause mortality, quality of life, and costs to society.
A Study Of The Impact Of Treating Electrographic Seizures In Term Or Near-term Infants With Neonatal Encephalopathy
Funder
National Health and Medical Research Council
Funding Amount
$1,365,184.00
Summary
Seizures in the newborn infant are common and may be harmful to the developing brain. They are not always recognised. This study investigates whether or not treating all seizures detected using a bedside brain activity monitor improves developmental outcome, compared to just treating seizures that doctors recognise.
Most strokes are ischaemic due to occlusion of an artery producing rapid reduction in blood flow to the brain. Positioning a patient ‘lying flat’ (i.e. ‘head down’ to be level with the body, which increases the blood flow to the brain, may improve recovery and reduce disability. This study aims to determine whether ‘lying flat’ head positioning is beneficial in patients with acute stroke. The results could lead to a cheaper, safer and more effective stroke care in the world.
Sydney Epilepsy Incidence Study To Measure Illness Consequences (SEISMIC)
Funder
National Health and Medical Research Council
Funding Amount
$694,067.00
Summary
Epilepsy is common, costly and neglected. This study is a prospective cohort study of newly diagnosed cases of epilepsy and aims to fill clinical, psychosocial and economic knowledge gaps in epilepsy. The network will use this new evidence for policy recommendations and strategic plans, for health systems and guidelines to improve efficiency and care and to enlighten community-based support programs, education, driving and workplace legislation. This study was developed by a health service, Epil ....Epilepsy is common, costly and neglected. This study is a prospective cohort study of newly diagnosed cases of epilepsy and aims to fill clinical, psychosocial and economic knowledge gaps in epilepsy. The network will use this new evidence for policy recommendations and strategic plans, for health systems and guidelines to improve efficiency and care and to enlighten community-based support programs, education, driving and workplace legislation. This study was developed by a health service, Epilepsy Action, Epilepsy Society of Australia and the George Institute.Read moreRead less
Australian Resuscitation Outcomes Consortium [AUS-ROC] CRE
Funder
National Health and Medical Research Council
Funding Amount
$2,668,571.00
Summary
The Australian Resuscitation Outcomes Consortium (Aus-ROC) will be modelled on the highly successful North American Resuscitation Outcomes Consortium. The mission of Aus-ROC will be to conduct clinical trials and observational studies into the emergency management of out-of-hospital cardiopulmonary arrest. Building on our existing collaborative partnerships, our goal is to improve patient outcomes and build the research capacity in prehospital emergency care.
Development of a Prothrombogenic Bone Graft Substitute. The clinical demand for bone is massive and to counter this bone can be either harvested from the patient or bone substitutes are used. The success or failure of a bone substitute is determined the instant it come into contact with blood. The surfaces of traditional biomaterials induce a foreign body reaction. The aim of this project is to test the bone forming capacity of a biomaterial that is optimised to produce a natural response from ....Development of a Prothrombogenic Bone Graft Substitute. The clinical demand for bone is massive and to counter this bone can be either harvested from the patient or bone substitutes are used. The success or failure of a bone substitute is determined the instant it come into contact with blood. The surfaces of traditional biomaterials induce a foreign body reaction. The aim of this project is to test the bone forming capacity of a biomaterial that is optimised to produce a natural response from the blood. This response will lead to the formation new viable tissue and eventually bone. Such a material will cause faster bone healing, less pain from graft sites, shorter hospital stays and shorter waiting lists. Read moreRead less
Development of a Light-Activated Bioadhesive for Low Temperature Tissue Repair. While sutures currently represent the gold standard for wound closure, their fundamental technology has changed little in thousands of years. Surgical sealants and energy based closure devices are expected to increasingly replace or complement sutures, improving tissue closure and wound healing. The innovative research in this proposal will develop the next generation of surgical bioadhesive technology and claim a s ....Development of a Light-Activated Bioadhesive for Low Temperature Tissue Repair. While sutures currently represent the gold standard for wound closure, their fundamental technology has changed little in thousands of years. Surgical sealants and energy based closure devices are expected to increasingly replace or complement sutures, improving tissue closure and wound healing. The innovative research in this proposal will develop the next generation of surgical bioadhesive technology and claim a stake in the estimated US$ 4 billion market. The project outcomes will enhance Australia's reputation in the biomedical field and will have world-wide social and health care benefits by ultimately allowing better functional healing through bioadhesives that can be effectively applied rapidly and consistently.Read moreRead less
The mechanics of being human. This project will lead to far more detailed understanding of skull mechanics in our own lineage. Results will be of great interest to international scholars in both evolutionary and biomedical fields and help to establish a primary position for Australia in the rapidly expanding area of computer simulation of biological structure. Further development on our own established protocols for automated transfer of CT scan data into finite element models, which have alread ....The mechanics of being human. This project will lead to far more detailed understanding of skull mechanics in our own lineage. Results will be of great interest to international scholars in both evolutionary and biomedical fields and help to establish a primary position for Australia in the rapidly expanding area of computer simulation of biological structure. Further development on our own established protocols for automated transfer of CT scan data into finite element models, which have already improved speed, accuracy and realism, will take finite element analysis to a point at which it can be more readily applied to evolutionary, biomedical and safety design questions.Read moreRead less
ANATOMICAL ORGAN MODELLING AND SURGICAL PROCEDURE SIMULATION FOR THORACOSCOPIC SURGERY. We aim to establish novel virtual reality-based surgical procedure simulation methodologies, geometric and physical models of human organs, and surgical tools and interaction modules for thoracoscopic surgery or for minimally invasive surgical procedures. This is needed to optimize surgical strategy and to anticipate possible problems that may arise during the procedure, and to train medical staff as the tren ....ANATOMICAL ORGAN MODELLING AND SURGICAL PROCEDURE SIMULATION FOR THORACOSCOPIC SURGERY. We aim to establish novel virtual reality-based surgical procedure simulation methodologies, geometric and physical models of human organs, and surgical tools and interaction modules for thoracoscopic surgery or for minimally invasive surgical procedures. This is needed to optimize surgical strategy and to anticipate possible problems that may arise during the procedure, and to train medical staff as the trend towards robotic-assisted minimally invasive surgery continues. What makes this project novel is the anatomical organ modeling approach based on virtual springs and dampers traversing between the top and bottom surfaces of the organs and tissues, contrary to previous approaches.Read moreRead less