Team Approach To Polypharmacy Evaluation And Reduction For General Practice Patients With Dementia: The Australian TAPERdem Study.
Funder
National Health and Medical Research Council
Funding Amount
$586,840.00
Summary
Dementia frequently coexists with other chronic conditions, posing a challenge to optimise medication use. Suboptimal pharmacological management of comorbidities exacerbates the rate of functional decline of PWD. The present study will determine to what extent improved medication management produces better health and functional outcomes for PWD.
Optimising Medicine Regimens For People With Dementia: Maintaining Function, Maximising Quality Of Life And Preventing Adverse Events
Funder
National Health and Medical Research Council
Funding Amount
$715,017.00
Summary
I am a pharmacist based at Monash University. My expanding research team generates and applies evidence to optimise medicine regimens for people with dementia. My research assesses the risks and benefits of medicines for dementia and other health conditions. I will also focus on research training and capacity building. My research ensures people with dementia and their clinicians are equipped with the best evidence to inform medicines management decisions to optimise health outcomes.
Optimising Pharmaceutical Care For People With Dementia In Acute Care Settings
Funder
National Health and Medical Research Council
Funding Amount
$719,637.00
Summary
Delivering appropriate acute care services for people with dementia is a major healthcare challenge in Australia. People with dementia do not receive appropriate care in hospitals and are more likely to experience worse clinical outcomes compared to people without dementia. This proposal will establish the first large-scale multi-centre cohort of inpatients with dementia, to systematically investigate the impact of hospitalisation on prescribing, clinical and patient-centred outcomes.
Centre For REdefining Antibiotic Use To ReDUce ResistanCE And Prolong The Lives Of Antibiotics (REDUCE)
Funder
National Health and Medical Research Council
Funding Amount
$2,158,296.00
Summary
Ineffective dosing of antimicrobials has contributed to the escalation of antimicrobial resistance which now pervades the healthcare system. Patients in the intensive care unit and post-transplant are examples of patients who commonly have infections, are more likely to fail treatment and have resistant microbes emerge. In these studies we will characterise the doses of antimicrobials that should be used in these difficult-to-treat patients and rapidly share these for routine clinical use.
Ineffective antibiotic therapy is associated with increased mortality in infected patients in the intensive care unit (ICU). Early administration of efficacious antibiotic therapy improves survival substantially. This work seeks to extend upon my previous studies that have described the different concentrations of antibiotics between ICU patients and non-ICU patients. Predicting when to change antibiotic doses in ICU patients is likely to substantially improve patient outcomes.
Innovative Dosing Approaches To Maximise Bacterial Killing And Prevent Resistance In Septic Critically Ill Patients.
Funder
National Health and Medical Research Council
Funding Amount
$830,364.00
Summary
Patients in the intensive care unit (ICU) frequently die from infection. It remains unknown how important antibiotic dose optimisation is for these patients and whether it may enable more effective treatment. In this project, we propose to compare existing approaches to antibiotic dosing in ICU patients with innovative alternatives. We will determine which dosing approach results in better antibacterial efficacy and reduce the development of antibiotic resistance.
Improving Quality Use Of Medicines In Residential Aged Care
Funder
National Health and Medical Research Council
Funding Amount
$175,303.00
Summary
Traditionally, antipsychotic medicines have been used to manage challenging behaviours in dementia yet research has shown these medicines have limited usefulness and are associated with increases in falls, stroke and death. Despite this, they are still commonly used. In this TRIP fellowship, we aim to evaluate the sustainability and generalizability of a multicomponent model to reduce the use of antipsychotics for managing dementia-related behavioural issues in residential aged care facilities.
Redefining Antibiotic Dosing To Reduce Bacterial Resistance
Funder
National Health and Medical Research Council
Funding Amount
$474,513.00
Summary
>3000 Australians die every year from severe infections (nearly 3-fold higher in number than our annual road toll). These treatment failures are due to sub-optimal antibiotic dosing from a poor understanding of why concentrations are different in these patients. I will use my laboratory to define what antibiotic concentrations we need to achieve and perform clinical studies with my collaborative network to demonstrate that we can redefine antibiotic dosing to reduce the emergence of superbugs ....>3000 Australians die every year from severe infections (nearly 3-fold higher in number than our annual road toll). These treatment failures are due to sub-optimal antibiotic dosing from a poor understanding of why concentrations are different in these patients. I will use my laboratory to define what antibiotic concentrations we need to achieve and perform clinical studies with my collaborative network to demonstrate that we can redefine antibiotic dosing to reduce the emergence of superbugs.Read moreRead less
Improving Dosing Of Common Antibiotics Used In Critically Ill Australian Indigenous Patients
Funder
National Health and Medical Research Council
Funding Amount
$98,148.00
Summary
Optimal antibiotic dosing in patients in the intensive care unit saves lives. However, the way antibiotics move through the body of an intensive care unit patient can be different to other patients. Therefore, research that identifies specific dosing for these patients is essential. Further to this, no research in an Indigenous population is available. The aim of this research is to address this gap by developing optimal antibiotic doses for Indigenous Australians in the intensive care unit.
Translation of evidence into pain management practices in acute care environments. This project addresses the urgent need to reduce the substantial pain experienced by patients following surgery by improving the clinical processes associated with the treatment of pain. Each year in Australia, six million people are admitted to hospital for surgery. A recent review of Australian research has shown that up to 40% of hospitalised surgical patients experience significant pain. Despite the availabili ....Translation of evidence into pain management practices in acute care environments. This project addresses the urgent need to reduce the substantial pain experienced by patients following surgery by improving the clinical processes associated with the treatment of pain. Each year in Australia, six million people are admitted to hospital for surgery. A recent review of Australian research has shown that up to 40% of hospitalised surgical patients experience significant pain. Despite the availability of effective treatment, pain after surgery is often under-treated and is one of the main postoperative adverse outcomes. A consequence of poor pain management is that patients experience unnecessary suffering, higher incidence of postoperative complications significant risk of developing chronic post-surgical pain.Read moreRead less