Interaction Of Mc1r With The PRb And P53 Pathways In UVR-induced Melanoma Development
Funder
National Health and Medical Research Council
Funding Amount
$553,479.00
Summary
This project will shed light onto fundamental processes causing UV-induced melanoma (MM). Innate differences between individuals, independent of pigmentation, influence MM development. We will study the mechanisms of UVR-induced MM development in mice carrying gene mutations (Cdk4, Arf, Mc1r) that underpin human MM susceptibility. Knowledge of the sensitivity of an one's MCs to UV could be critical for targeting susceptible groups for health education campaigns and more intense screening.
Sun Exposure, Vitamin D And The Outcome Of Prostate Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$494,698.00
Summary
We will find out whether hours of sun exposure, reported in a standard interview by men with prostate cancer, reduces prostate cancer recurrence and progression. For any effect of sun exposure ithat we observe, we will find out whether it works through vitamin D, which is produced by sunshine on the skin, or is affected by changes in the vitamin D receptor gene, which produces the protein the binds with vitamin D on cells and makes it work. Prostate cancer is the most common cancer in men in Aus ....We will find out whether hours of sun exposure, reported in a standard interview by men with prostate cancer, reduces prostate cancer recurrence and progression. For any effect of sun exposure ithat we observe, we will find out whether it works through vitamin D, which is produced by sunshine on the skin, or is affected by changes in the vitamin D receptor gene, which produces the protein the binds with vitamin D on cells and makes it work. Prostate cancer is the most common cancer in men in Australia, and this study, using two of the largest collections of clinical outcomes data for this disease, will inform researchers, clinicians and consumers about the possible benefits of sun exposure and Vitamin D in the prevention of recurrence or progression of prostate cancer. On present evidence, these effects are very plausible possibilities. It may also identify sub-groups of men in whom sun exposure or vitamin D might be particularly beneficial in improving outcome of prostate cancer.Read moreRead less
Further Characterisation Of The Role Of HSSB1 In DNA Repair And Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$85,526.00
Summary
To date, all breast cancer predisposition genes identified play an important role in the DNA damage repair pathway. We have characterised a new protein designated as hSSB1, which plays a crucial role in the maintenance of genomic stability by protecting us from DNA damage. Significantly, evidence strongly suggests an interaction of hSSB1 with the breast cancer susceptibility protein BRCA2. This project will investigate the role of hSSB1 in breast cancer predisposition and DNA damage repair.
An In-vivo Model Of Acquired Chemoresistance In Small Cell Lung Cancer
Funder
National Health and Medical Research Council
Funding Amount
$363,827.00
Summary
Lung cancer is a common and lethal disease in our community. In this project, we explore how a very aggressive form of lung cancer becomes resistant to chemotherapy. To do this, we use a new mouse model of lung cancer in which we can study how human lung cancer cells develop resistance to chemotherapy in vivo. Understanding these pathways will help us to better treat lung cancer with chemotherapy.
Investigation Of Cancer Predisposition In Heterozygous Carriers Of The ATM
Funder
National Health and Medical Research Council
Funding Amount
$822,750.00
Summary
Individuals with the human genetic disorder ataxia-telangiectasia are prone to cancer development and so also are their parents and relatives (carriers) who have one defective copy of the gene. This is a multisystem disease that is also characterized by neurodegeneration, immunodeficiency, infertility and extreme sensitivity to radiation. This project is designed to generate a mouse model of this disease to investigate cancer susceptibility in carriers of the defective gene. The specific mutatio ....Individuals with the human genetic disorder ataxia-telangiectasia are prone to cancer development and so also are their parents and relatives (carriers) who have one defective copy of the gene. This is a multisystem disease that is also characterized by neurodegeneration, immunodeficiency, infertility and extreme sensitivity to radiation. This project is designed to generate a mouse model of this disease to investigate cancer susceptibility in carriers of the defective gene. The specific mutation to be introduced into the mouse has been described in a patient with breast cancer and it has been shown to interfere with the normal function of the ATM protein. The mouse model is expected to reflect closely the human disease and will provide the opportunity to monitor heterozygous carriers for the development of cancer. This model is expected to confirm the observations in humans and provide a resource to understand susceptibility to develop cancer. The model will also address the issue of exposure to low dose radiation and risk of developing cancer.Read moreRead less
Improved Formulations Of Anti-cancer Agents 5-Fluorouracil And Oxaliplatin Using Excipient Technology
Funder
National Health and Medical Research Council
Funding Amount
$202,973.00
Summary
Chemotherapy plays a key role in cancer treatment, however, problems persist with severe adverse toxic effects. Combinations of anti-cancer agents give better results, but these agents still have major negative effects, for example, on veins and peripheral nerves and they must be given separately. We have developed a novel, all-in-one formulation of Oxaliplatin with 5-Fluorouracil and Leucovorin, with the potential for fewer toxic effects and improved patient care.