A Randomised Placebo-controlled Trial Of Antibiotics To Prevent Urinary Tract Infection In Children
Funder
National Health and Medical Research Council
Funding Amount
$735,000.00
Summary
This study is needed to determine whether a common clinical practice long-term antibiotic treatment for children following urinary tract infection (UTI) - is safe and effective in preventing further UTI and if so, whether all appropriate children are being treated. UTI will affect about 10% of Australian children by high school age (88,000 children per year). Because UTI may damage the kidneys, the management priority for children with UTI has been prevention of further infection. Currently this ....This study is needed to determine whether a common clinical practice long-term antibiotic treatment for children following urinary tract infection (UTI) - is safe and effective in preventing further UTI and if so, whether all appropriate children are being treated. UTI will affect about 10% of Australian children by high school age (88,000 children per year). Because UTI may damage the kidneys, the management priority for children with UTI has been prevention of further infection. Currently this means the identification of children thought to be most at risk of recurrent UTI by renal tract imaging. Those found to have reflux of urine from the bladder to the kidney (present in about 30% of those with UTI) are then placed on antibiotics fro 2-5 years. Unfortunately there has never been a properly designed trial to test whether antibiotics do really prevent UTI and if so, whether children with reflux are the appropriate and only group requiring treatment. Long term antibiotics may in fact do more harm than good because of side effects like skin, bowel and blood problems and because resistant bacteria may develop. The design of this study involves the random allocation of placebo or antibiotic (cotrimoxazole, the usual antibiotic given in this case) to about 800 children after their first symptomatic UTI. These children are treated and followed for one year to determine the rate of futher UTI in both groups. Any difference in outcome between the two groups of children will be because of the antibiotic treatment. This study may prove long-term antibiotics are ineffective and therefore should not be routinely used. In this case investigation of children to detect vesicoureteric reflux would serve little purpose and should be abandoned. Alternatively antibiotic treatment may be shown as effective treatment for preventing further UTI and in this case the study will clearly identify those children who will benefit.Read moreRead less
School drug education for junior high school students in Victoria - Assessing the impact of a state-wide, evidence-based intervention
. Young people are faced with numerous and powerful influences to use both legal and illicit drugs, and drug education can play an important counterbalancing role in shaping a normative culture of safety, moderation and informed decision making in this group. The research will develop, implement and evaluate one all encompassing, evidence-based, drug education pr ....School drug education for junior high school students in Victoria - Assessing the impact of a state-wide, evidence-based intervention
. Young people are faced with numerous and powerful influences to use both legal and illicit drugs, and drug education can play an important counterbalancing role in shaping a normative culture of safety, moderation and informed decision making in this group. The research will develop, implement and evaluate one all encompassing, evidence-based, drug education program for junior high school students across Victoria. The study is unique in its size and scope and will be of national benefit because its findings will influence the nature of future drug education in all secondary schools in Australia.Read moreRead less
Automated groundwater level mapping: a tool for catchment scale estimation of aquifer storage changes, fluxes and hydrogeological properties. Cutting-edge groundwater mapping tools will be developed by this project and made freely available. Water table maps will be derived for Victoria and used to quantify aquifer properties, recharge and the groundwater balance. Fundamental limitations to quantitative groundwater management will be overcome and the Bureau of Meteorology intend to adopt the fin ....Automated groundwater level mapping: a tool for catchment scale estimation of aquifer storage changes, fluxes and hydrogeological properties. Cutting-edge groundwater mapping tools will be developed by this project and made freely available. Water table maps will be derived for Victoria and used to quantify aquifer properties, recharge and the groundwater balance. Fundamental limitations to quantitative groundwater management will be overcome and the Bureau of Meteorology intend to adopt the findings.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100159
Funder
Australian Research Council
Funding Amount
$160,000.00
Summary
Mobile Australian field isotope alliance. This project will enable a quantum leap in capacity to undertake, real-time, field-based studies of environmental processes using the natural isotope tracers of carbon, oxygen and hydrogen. This will enable the project to address a range of fundamental research questions in climate change, water resources, ecology and human impact in tropical Australia.
Cross-cultural management of freshwater on resource-constrained islands. This project aims to develop a methodology for community-led adaptive water management on resource-constrained islands and will involve Indigenous communities in the development of predictive groundwater models. The project plans to apply three-dimensional participatory mapping, a stakeholder engagement process led and owned by the local communities, on Milingimbi Island in the Northern Territory. The extension of the parti ....Cross-cultural management of freshwater on resource-constrained islands. This project aims to develop a methodology for community-led adaptive water management on resource-constrained islands and will involve Indigenous communities in the development of predictive groundwater models. The project plans to apply three-dimensional participatory mapping, a stakeholder engagement process led and owned by the local communities, on Milingimbi Island in the Northern Territory. The extension of the participatory mapping with a subsurface component will then support the conceptualisation and development of a numerical model of the island's groundwater system. The predictive model and community engagement processes are expected to provide a more robust methodology for evaluating future water management plans. The project outcomes will contribute to solving water supply problems in remote communities in Australia, and overseas.Read moreRead less
Understanding The Acute And Cumulative Metabolic Effects Of Prolonged Sitting In Adults
Funder
National Health and Medical Research Council
Funding Amount
$416,597.00
Summary
Sedentary behaviour (sitting time) has been linked to an increased risk of chronic illnesses, including type 2 diabetes and obesity, but recent evidence suggests that light-intensity activity (non-exercise activities of daily living) is associated with reduced risk. These studies will examine whether breaking up sitting time with frequent short periods of activity can overcome the negative effects of prolonged sitting on blood glucose and blood fats in overweight older adults.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100144
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
Mobile isotope monitoring for environmental studies. This facility will enable a quantum leap in Australia's capacity to undertake real-time, field based studies of environmental processes using the natural isotope tracers of carbon, oxygen and hydrogen. It will enable the researchers to address a range of fundamental research questions in climate change, water resources, ecology and human impact in tropical Australia.