Defining The Clinical Role Of Topiramate In The Treatment Of Alcohol Dependence In Australia
Funder
National Health and Medical Research Council
Funding Amount
$718,836.00
Summary
We urgently require new strategies for the treatment of alcohol dependence. The effectiveness of currently approved alcohol medications is limited. Emerging data suggests that topiramate has robust effectiveness and that better medicine selection is possible for patients based on their genotype. We propose to conduct a double-blind randomised controlled trial to examine the clinical and cost effectiveness of topiramate using a genetically based personalised approach.
Mental Health First Aid Training In The Workplace: A Randomized Controlled Trial Of Online And Blended Modes
Funder
National Health and Medical Research Council
Funding Amount
$540,247.00
Summary
This project will evaluate the effects of Mental Health First Aid (MHFA) training, which aims to teach members of the public how to support people they know who are developing a mental health problem or are in a mental health crisis. Training will be offered to Victorian public servants to see whether it changes their knowledge, attitudes and helping behaviour. MHFA training will be delivered either online or as a blend of online with face-to-face teaching, and will be compared with online Red C ....This project will evaluate the effects of Mental Health First Aid (MHFA) training, which aims to teach members of the public how to support people they know who are developing a mental health problem or are in a mental health crisis. Training will be offered to Victorian public servants to see whether it changes their knowledge, attitudes and helping behaviour. MHFA training will be delivered either online or as a blend of online with face-to-face teaching, and will be compared with online Red Cross physical first aid training as a control.Read moreRead less
The N-ICE Trial: A Randomised Controlled Trial Of The Safety And Efficacy Of N-Acetyl Cysteine (NAC) As A Pharmacotherapy For Methamphetamine (“ice”) Dependence
Funder
National Health and Medical Research Council
Funding Amount
$1,551,368.00
Summary
Crystalline methamphetamine (aka ‘ice’) is a significant public health concern in Australia and globally. Currently there are no approved medications to treat methamphetamine dependence. We will trial tN-acetyl-cysteine (NAC) as a medications for methamphetamine dependence.
Randomised Double-blind Placebo-controlled Study Of Lisdexamfetamine For The Treatment Of Methamphetamine Dependence
Funder
National Health and Medical Research Council
Funding Amount
$1,303,735.00
Summary
Addiction to methamphetamines (‘ice’) is a growing community problem linked to serious disease and death. Current counselling approaches have limited success on their own, and more effective treatments linked to medications are needed. Lisdexamfetamine is a newly licenced stimulant medication with great promise in treating these patients. This trial will examine whether lisdexamfetamine (with counselling) safely reduces methamphetamine use and improves health and wellbeing among heavy users.
Aboriginal And Non-Aboriginal Women Perpetrators Of Violence: A Trial Of A Prison-based Intervention (Beyond Violence)
Funder
National Health and Medical Research Council
Funding Amount
$1,411,825.00
Summary
The proposed study will be the first of its kind in Australia to test a violence prevention program (Beyond Violence) targeting mental health, substance use and violence among incarcerated female offenders with a history of violence. This research responds to the rapidly escalating imprisonment rates among Aboriginal and non-Aboriginal women (particularly for violent offences), and focuses intervention efforts on improving well-being and decreasing reoffending among this vulnerable group.
Alcohol And Other Drug Treatment Funding, Purchasing And Workforce: Empirical Analyses To Inform Policy
Funder
National Health and Medical Research Council
Funding Amount
$473,865.00
Summary
Alcohol and drug treatment works: it improves health and reduces the social impact of alcohol and drug use. The treatment itself is not, however, the only variable that impacts on whether health outcomes are improved. The way in which governments fund, purchase and structure the treatment service system is also important. This study will empirically test the relationship between treatment outcome and the structures that governments put in place, providing new evidence to inform decision-making.
Pubertal Transitions In Mental Health And Behaviour: The PHASE-A Study Of Social Roleand Lifestyle Transitions
Funder
National Health and Medical Research Council
Funding Amount
$1,656,785.00
Summary
Over the past four decades problems such as depression, anxiety, self-harm and substance abuse have increased in young people. Recent research indicates that puberty is a time when these problems commonly first emerge. This five-year study of 4000 students will examine a question of whether social transitions that are too soon (e.g. early initiation of sex) or problematic (e.g. bullying from peers) may explain the increase in these health problems as children pass through puberty.
Randomised Controlled Trial Of An Integrated Cognitive-behavioural Therapy For The Treatment Of Co-occurring Post Traumatic Stress Disorder And Substance Use Disorder In Adolescents
Funder
National Health and Medical Research Council
Funding Amount
$945,647.00
Summary
There is an urgent need to address the hidden epidemic of child and adolescent trauma and prevent the associated psychological and physical health problems that can persist into adulthood. This study, conducted across three States in Australia, will address a significant gap by evaluating a world-first treatment for post traumatic stress disorder (PTSD) and substance use among adolescents. By intervening early, the enduring disability and public health expenditure associated with these condition
A Pragmatic Randomised Clinical Trial Of Nicotine Vaporisers Added To Smoking Cessation Treatment For Priority Populations Living With Comorbidities
Funder
National Health and Medical Research Council
Funding Amount
$1,499,145.00
Summary
Smoking is a leading cause of early death for people with certain health conditions because they are more likely to smoke and are also at greater risk of tobacco-related disease. This clinical trial will test whether encouraging people living with Hepatitis C Virus, people on opiate substitution therapy and people living with HIV who smoke to use nicotine vaporisers long-term, in addition to current smoking cessation treatments, will help them to stay abstinent from smoking.
Investigating The Relationships Between Alcohol And Other Drug Use, Mental Health, Early-life Factors And Life-course Outcomes: Integrative Analyses Of Data From Four Australasian Cohort Studies
Funder
National Health and Medical Research Council
Funding Amount
$448,198.00
Summary
The current study will use a highly innovative approach to pool data from four large and long-running Australasian cohort studies to better understand the developmental precursors and psychosocial consequences of teen drinking behaviours. Findings will provide dramatically improved knowledge of the developmental pathways to teen and young adult drinking and a clearer picture of the total burden of disease attributable to alcohol in an Australasian setting.