From neuroscience to society: A multi-disciplinary study of human perception and cognition. This project aims to use a multi-disciplinary approach to investigate the factors influencing human perception and cognition - from the level of basic neuroscience, through to the wider impact felt by individuals and society when these functions are either impaired or enhanced. This will inform the basic research question of how the brain generates a conscious experience, identify the relationship between ....From neuroscience to society: A multi-disciplinary study of human perception and cognition. This project aims to use a multi-disciplinary approach to investigate the factors influencing human perception and cognition - from the level of basic neuroscience, through to the wider impact felt by individuals and society when these functions are either impaired or enhanced. This will inform the basic research question of how the brain generates a conscious experience, identify the relationship between altered visual cognitive function and clinical symptoms of psychosis, and determine the current prevalence and neuroethical issues associated with the non-medical use of drugs to enhance cognitive or perceptual function within Australia.Read moreRead less
Improving social, economic and health outcomes through drug policy reforms. Globally, recognition is growing that common prohibitionist drug policies contribute to drug-related harms and have not succeeded. Identified harms include the current drug overdose crisis in North America and a surge in overdose deaths in Australia, adding new force to calls for urgent reform. This project aims to respond to these calls by exploring how human rights considerations can inform improvements to drug policy. ....Improving social, economic and health outcomes through drug policy reforms. Globally, recognition is growing that common prohibitionist drug policies contribute to drug-related harms and have not succeeded. Identified harms include the current drug overdose crisis in North America and a surge in overdose deaths in Australia, adding new force to calls for urgent reform. This project aims to respond to these calls by exploring how human rights considerations can inform improvements to drug policy. The project seeks to generate new knowledge on how human rights can guide reform so as to improve social, economic and health outcomes. The project should provide significant benefits to the nation, informing Australian legal, policy and practice reforms as well as international efforts to reduce drug-related harms.Read moreRead less
Reimagining strengths approaches to drug and alcohol care for young people. This project aims to advance the conceptualisation and practical application of strengths-based approaches in the youth alcohol and drug sector. These approaches provide a promising way forward for addressing substance use and disadvantage among young people, and are widespread in the sector, but lack a strong evidence base. The project will learn from excellence in Aboriginal strengths-based models, and draw on sociolog ....Reimagining strengths approaches to drug and alcohol care for young people. This project aims to advance the conceptualisation and practical application of strengths-based approaches in the youth alcohol and drug sector. These approaches provide a promising way forward for addressing substance use and disadvantage among young people, and are widespread in the sector, but lack a strong evidence base. The project will learn from excellence in Aboriginal strengths-based models, and draw on sociological frameworks, to generate evidence on which to build more relevant responses for disadvantaged young people. This will provide significant benefit to service providers and policymakers by providing evidence about how to do strengths-based practice that is responsive to the needs of disadvantaged young people.Read moreRead less
A community-based approach to the problem of underage drinking. This project will aim to reduce the frequency and amount of alcohol consumption, and alcohol-related harms, among young people aged 12-17 years by addressing social norms regarding underage alcohol consumption. Using a multi-component intervention it will engage the Illawarra community in strategies to encourage and empower young people not to drink.
Ethical frameworks for responsible innovation of neurotechnology. This project aims to ensure the ethical and efficient innovation of emerging neurotechnologies, including implantable brain devices, synthetic drugs and direct-to-consumer brain devices. This project expects to generate Australian’s first responsible innovation framework through extensive community engagement. Expected outcomes of this project include: guidelines for the development of neurotechnologies; a national framework for r ....Ethical frameworks for responsible innovation of neurotechnology. This project aims to ensure the ethical and efficient innovation of emerging neurotechnologies, including implantable brain devices, synthetic drugs and direct-to-consumer brain devices. This project expects to generate Australian’s first responsible innovation framework through extensive community engagement. Expected outcomes of this project include: guidelines for the development of neurotechnologies; a national framework for responsible innovation; partnerships with international brain initiatives; and enhanced interdisciplinary capacity. The proposed research should provide significant benefits: innovation of technologies that meet Australians' needs, reduced misuse and harm, and greater social support for innovation in neuroscience.Read moreRead less
The life-course implications of declining adolescent drinking. The project aims to identify ways to ensure that recent declines in adolescent drinking are maintained and reinforced as these cohorts age into young adulthood. It expects to generate new knowledge on the trajectories of youth drinking into young adulthood. Expected outcomes include new cross-national understandings of the predictors of heavy drinking in adulthood and an updated evidence base for the development of harm prevention po ....The life-course implications of declining adolescent drinking. The project aims to identify ways to ensure that recent declines in adolescent drinking are maintained and reinforced as these cohorts age into young adulthood. It expects to generate new knowledge on the trajectories of youth drinking into young adulthood. Expected outcomes include new cross-national understandings of the predictors of heavy drinking in adulthood and an updated evidence base for the development of harm prevention policies and interventions by governments and NGOs. This should provide significant benefits to Australia via reductions in the negative health and social impacts of heavy drinking for these cohorts across their lives. Read moreRead less
Bioactive Peptides as Pharmacological Tools and Novel Drug Leads. Bioactive peptides are produced by all organisms and play numerous critical physiological roles, including in cellular communication, host defence and capture of prey. Peptides have huge potential as tools for studying roles of signalling pathways and as novel drugs due to their high affinity and selectivity for various therapeutically relevant targets. However their use has been limited by poor in vivo stability. This project is ....Bioactive Peptides as Pharmacological Tools and Novel Drug Leads. Bioactive peptides are produced by all organisms and play numerous critical physiological roles, including in cellular communication, host defence and capture of prey. Peptides have huge potential as tools for studying roles of signalling pathways and as novel drugs due to their high affinity and selectivity for various therapeutically relevant targets. However their use has been limited by poor in vivo stability. This project is focused on studying structural features of a range of peptides and their contributions to both activity and to resistance against degradation, with the aim to develop stabilised bioactive peptide sequences for in vivo applications, allowing the full potential of peptides as drugs to be realised.Read moreRead less
Policy frameworks and market/non-market activity of young and older adults . The project intends to compare the social and economic participation of young adults and older people across nations to reveal best practice policy in engaging both ends of the age spectrum in productive activity. Population ageing has implications for the wellbeing and prosperity of both the older and younger generations. This project intends to investigate how contemporary young adults and older people spend their tim ....Policy frameworks and market/non-market activity of young and older adults . The project intends to compare the social and economic participation of young adults and older people across nations to reveal best practice policy in engaging both ends of the age spectrum in productive activity. Population ageing has implications for the wellbeing and prosperity of both the older and younger generations. This project intends to investigate how contemporary young adults and older people spend their time in productive activities across countries with contrasting policy frameworks. This may yield important policy-relevant information for Australia on how to both protect the old and invest in the young, while balancing financial sustainability and the principles of social justice and fairness.Read moreRead less
Fate of engineered nanoparticles: Challenges in informing human and ecological health risk assessments. Engineered nanoparticles (ENPs) have generated significant public and scientific excitement due to their unique properties. This has led to their application in a wide variety of industries (for example, in composite materials and drug delivery). However, there is concern that some ENPs can have detrimental environmental impacts. This project aims to quantify, for the first time, the fate of E ....Fate of engineered nanoparticles: Challenges in informing human and ecological health risk assessments. Engineered nanoparticles (ENPs) have generated significant public and scientific excitement due to their unique properties. This has led to their application in a wide variety of industries (for example, in composite materials and drug delivery). However, there is concern that some ENPs can have detrimental environmental impacts. This project aims to quantify, for the first time, the fate of ENPs that have leached out of commercial products in groundwater systems. This information is expected to assist regulators in developing appropriate legislation to balance the tremendous benefits and potential risks of nanotechnology.Read moreRead less
New data-driven mathematical models of collective cell motion. Cancer and chronic wounds are a national, and indeed, international health problem set to worsen as our population ages. Predictive and interpretive tools are required to improve our understanding of collective cell migration in relation to cancer and chronic wounds. This project will produce new validated mathematical tools for predicting collective cell migration in a general framework that can deal with application-specific detail ....New data-driven mathematical models of collective cell motion. Cancer and chronic wounds are a national, and indeed, international health problem set to worsen as our population ages. Predictive and interpretive tools are required to improve our understanding of collective cell migration in relation to cancer and chronic wounds. This project will produce new validated mathematical tools for predicting collective cell migration in a general framework that can deal with application-specific details, such as the role of cell shape and cell size. Although cell shape and size are known to affect collective cell migration, standard mathematical models ignore these details. This project will produce new predictive mathematical modelling tools that are validated by new experimental data. Read moreRead less