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As women age, the quality of their eggs decline and their chance of having a healthy baby plummets. The accumulation of DNA damage within the egg, and the reduced ability to repair this damage, may be one cause of compromised reproductive success in older women. This project will investigate the ability of eggs to repair DNA damage during maternal aging and will explore the importance of DNA repair to fertility and the transmission of high quality genetic material to their offspring.
Examining The Importance Of DNA Damage Repair For Oocyte Quality, Female Fertility And Offspring Health
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
As women age, the quality of their eggs decline and their chance of having a healthy baby plummets. The accumulation of DNA damage within the egg, and the reduced ability to repair this damage, may be one cause of compromised reproductive success in older women. This project will investigate the ability of eggs to repair DNA damage during maternal aging and will explore the importance of DNA repair to fertility and the transmission of high quality genetic material to their offspring.
Defining winning strategies in a changing Southern Ocean . The ecosystem of the Southern Ocean is extremely complex, and understanding its response to rapid climate change is challenging. The aim of the project is to use changes in the behaviour of marine predators to provide new measures of integrated changes in eastern Antarctic ecosystems throughout the winter. With novel combinations of electronic tagging, natural biogeochemical markers, and simulation modelling, the project expects to recon ....Defining winning strategies in a changing Southern Ocean . The ecosystem of the Southern Ocean is extremely complex, and understanding its response to rapid climate change is challenging. The aim of the project is to use changes in the behaviour of marine predators to provide new measures of integrated changes in eastern Antarctic ecosystems throughout the winter. With novel combinations of electronic tagging, natural biogeochemical markers, and simulation modelling, the project expects to reconstruct changes in animal behaviour in response to changes in the environment. The data is anticipated to explain ongoing large-scale shifts in Southern Ocean ecosystems, providing information needed to underpin future management and adaptation strategies.Read moreRead less
Dynamics of childbearing in Australia in the first decade of the twenty-first century. Why did Australian fertility increase in the first decade of the twenty-first century? This project examines the roles of government policies and social changes on childbearing preferences and behaviours in the 2000's and in doing so contributes to a sustainable Australia by informing family and population policy.
Health And Fertility Of Young Men Conceived Using Intra-cytoplasmic Sperm Injection
Funder
National Health and Medical Research Council
Funding Amount
$362,570.00
Summary
The injection of a single sperm into the egg (ICSI) has been the main IVF treatment for men with poor sperm quality since 1993 but is now often used for other types of infertility. Concern has been raised about the health of the children. We will approach >800 parents and their adult sons conceived using ICSI and will assess his general health and development, and fertility. This work will improve patient counselling and practice guidelines, and direct research into the safety of ICSI.
Emerging Severe Mental Illness In Young People: Clinical Staging, Neurobiology, Prediction & Intervention From Vulnerabi
Funder
National Health and Medical Research Council
Funding Amount
$6,229,421.00
Summary
Mental disorders, such as psychotic and severe mood disorders, are the largest cause of disability in Australia. However, there is still little known about illness onset, relapse and progression. We have developed a clinical staging model with transition points from symptomfree to subthreshold status, to threshold disorder to chronic disability. We will investigate neurobiological and psychosocial factors which increase the risk of progression through these stages and use this model as a basis f ....Mental disorders, such as psychotic and severe mood disorders, are the largest cause of disability in Australia. However, there is still little known about illness onset, relapse and progression. We have developed a clinical staging model with transition points from symptomfree to subthreshold status, to threshold disorder to chronic disability. We will investigate neurobiological and psychosocial factors which increase the risk of progression through these stages and use this model as a basis for examining the effectiveness of interventions, for example to prevent, delay or ameliorate onset and relapse, and promote vocational recovery. Thus major clinical and public health benefits and an understanding of factors that contribute to the onset and progression of illness will result.Read moreRead less
Waste Containment Lining Systems for Antarctica: Ensuring their Performance Under Extreme Conditions. The Australian Antarctic Territory, and elsewhere on the continent, has a legacy of diesel fuel spills. This project aims to better protect the Antarctic environment through a combination of innovative on-site containment and remediation, with state-of-art laboratory-based experimentation to underpin improved design of engineered geosynthetic composite containments. Currently Australia leads ot ....Waste Containment Lining Systems for Antarctica: Ensuring their Performance Under Extreme Conditions. The Australian Antarctic Territory, and elsewhere on the continent, has a legacy of diesel fuel spills. This project aims to better protect the Antarctic environment through a combination of innovative on-site containment and remediation, with state-of-art laboratory-based experimentation to underpin improved design of engineered geosynthetic composite containments. Currently Australia leads other Antarctic countries in the clean-up of contaminated sites and this project seeks to extend this leadership by developing a set of guidelines for containment of contaminated soils to safeguard this unique environment.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220101027
Funder
Australian Research Council
Funding Amount
$455,906.00
Summary
Resolving ocean convection: new knowledge for a changing Antarctica. This project aims to improve our understanding of the role of convection on the Antarctic margins using a high-resolution, cutting-edge numerical approach. Convection is an important, but poorly understood oceanic process, which diverts heat away from the melting Antarctic ice shelves by transporting cold and salty water from the ocean surface to depth. The project outcomes will be new knowledge of the physics from novel numeri ....Resolving ocean convection: new knowledge for a changing Antarctica. This project aims to improve our understanding of the role of convection on the Antarctic margins using a high-resolution, cutting-edge numerical approach. Convection is an important, but poorly understood oceanic process, which diverts heat away from the melting Antarctic ice shelves by transporting cold and salty water from the ocean surface to depth. The project outcomes will be new knowledge of the physics from novel numerical models and theory, supported by insights from observations and model parameterisations. This timely research will improve prediction of sea level rise due to a changing Antarctica and enhance our ability to adapt to future climate scenarios, providing significant environmental and health benefits to Australians.Read moreRead less
Epidemics, mortality and longevity in Tasmania, 1838-1930. This project will investigate areas of contemporary importance that can only be explored using historic-demographic data. National benefits include (1) gaining a better understanding of how epidemics spread through families and communities, and possible mortality and case-fatality rates, to assist in preparation for future epidemics; (2) improved accuracy in projecting older-age mortality and population ageing in Australia and other coun ....Epidemics, mortality and longevity in Tasmania, 1838-1930. This project will investigate areas of contemporary importance that can only be explored using historic-demographic data. National benefits include (1) gaining a better understanding of how epidemics spread through families and communities, and possible mortality and case-fatality rates, to assist in preparation for future epidemics; (2) improved accuracy in projecting older-age mortality and population ageing in Australia and other countries; and (3) more precise estimates of women's capacity to naturally conceive and carry to term by characteristics such as her age, her partner's age, and her number of previous births. The project will also result in augmentation of a unique publicly available dataset.Read moreRead less
Special Research Initiatives - Grant ID: SR200200298
Funder
Australian Research Council
Funding Amount
$268,000.00
Summary
Casual Fertility Consequences: The Role of Non-Standard Employment (NSE). This project aims to investigate the role of temporary, casual, part-time paid work (non-standard employment) on Australians’ fertility behaviour (childbirth intentions and outcomes). It expects to use high-quality longitudinal data, engage in novel quasi-experiments (policy changes) to identify new causal mechanisms and pathways between employment types and fertility. Expected outcomes include a novel interdisciplinary th ....Casual Fertility Consequences: The Role of Non-Standard Employment (NSE). This project aims to investigate the role of temporary, casual, part-time paid work (non-standard employment) on Australians’ fertility behaviour (childbirth intentions and outcomes). It expects to use high-quality longitudinal data, engage in novel quasi-experiments (policy changes) to identify new causal mechanisms and pathways between employment types and fertility. Expected outcomes include a novel interdisciplinary theoretical framework, most up-to-date empirical evidence on this topic in Australia, high-quality research outputs and training, and clear work and family policy recommendations. This should significantly benefit families, communities, governments and organisations to lift productivity. Read moreRead less