Physical Activity Coaching For Adults With Physical Disabilities: A Pragmatic Randomised Controlled Trial.
Funder
National Health and Medical Research Council
Funding Amount
$1,371,185.00
Summary
People with impaired mobility can achieve substantial benefits from appropriate physical activities but face many barriers to being active so require targeted interventions and health professional support. This trial (n=600) will test the effectiveness and cost-effectiveness of an enhanced physical activity coaching intervention (home-visit from a physiotherapist, phone coaching, technology) with phone coaching alone and with no intervention.
Preventing The Evolution Of Transmissible Nitroimidazole Resistance In Mycobacterium Tuberculosis
Funder
National Health and Medical Research Council
Funding Amount
$664,463.00
Summary
Tuberculosis kills more people than any other infectious disease. Unfortunately, the drugs available to us to treat TB are losing their efficacy due to the evolution of drug resistance. A new class of drugs, nitroimidazoles, has been developed, but there is a risk that the bacterium that causes TB will develop resistance to these compounds too. We will identify resistance mutations before they occur in the wild, to help identify them and find new compounds for which resistance cannot develop.
Discovery Of Active Metabolic Pathways Suitable For Drug Targeting In Trypanosoma Brucei
Funder
National Health and Medical Research Council
Funding Amount
$485,517.00
Summary
Sleeping Sickness is a parasitic disease affecting many of the world’s poorest countries, and is fatal if left untreated. The aim of this project is to identify new metabolic pathways in the parasite that causes Sleeping Sickness, and to investigate how drugs interfere with parasite metabolism. This will provide the basis for new drug discovery efforts and facilitate the development of new medicines for Sleeping Sickness.
IMproving Physical ACtivity With Treadmill Training Following Stroke: The Stroke-IMPACT Trial
Funder
National Health and Medical Research Council
Funding Amount
$736,065.00
Summary
Stroke is a leading cause of disability amongst Australians. After stroke, activity levels are low, with few people able to exercise at an intensity which will reduce the risk of future cardiovascular events. This project examines the effectiveness of combining a high intensity treadmill training program with a self management approach to improve activity levels, mobility, cardiovascular risk profile in stroke survivors, increasing their independence and reducing the burden of care.
A Cluster Randomised Trial Of Electronic Feedback, Online And Telephone Support On Multiple Health Risk Behaviours Among Technical And Further Education (TAFE) Students
Funder
National Health and Medical Research Council
Funding Amount
$634,076.00
Summary
This trial will examine whether electronic feedback and enrolment of TAFE students into online and telephone services reduces smoking rates and risky alcohol consumption and increases fruit and vegetable intake and physical activity levels in the long-term. Thirty-two TAFE campuses will participate. At intervention campuses, electronic feedback and online and telephone services will be offered to students for health behaviours which they do not meet Australian health guidelines.
There’s recent evidence that children get leaner and fitter during the school term, but become fatter and less fit over the summer holidays. This may be because of differences in activity and diet: on holidays, children may eat more, be less active and have more screen time. We propose to track the time use, diet, fitness and fatness of 9-11 year old children across three school years. If the pattern is confirmed, we should focus more on the home environment, or perhaps encourage summer camps.
Cardiometabolic Risk Trajectories From Childhood To Midlife: Finding Pathways To Better Health
Funder
National Health and Medical Research Council
Funding Amount
$1,531,987.00
Summary
Using data from a large cohort of Australian children followed for over 30 years, this study will investigate how weight status and physical fitness from childhood to adulthood determine early markers of cardiovascular disease and type 2 diabetes (cardiometabolic disease) in midlife. It will provide much needed evidence to address the high prevalence of cardiometabolic disease risk factors in young Australians through better targeted disease prevention and early clinical intervention strategies.
Participate-CP: Optimising Participation In Physically Active Leisure For Children With Cerebral Palsy: A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,014,872.00
Summary
In Australia, 35,000 people have cerebral palsy, who compared to able-bodied peers, are less active with a greater risk of chronic, life-limiting health conditions. There are currently no effective interventions for children with cerebral palsy to increase their physical activity and participation in active leisure activities. We have promising data about a new intervention, called Participate-CP, which we will test in 80 children with cerebral palsy and compare results to usual therapy care.
A Nanomedicine Strategy For Detecting And Modulating Protease Activity In Vivo
Funder
National Health and Medical Research Council
Funding Amount
$455,534.00
Summary
Protease enzymes are vitally important for normal bodily function but can play a deleterious role in many diseases such as cancer, aging diseases and eye diseases. The proposed research will provide a nanomedicine solution to the detection and therapeutic control of protease activity in vivo using nanoporous optical devices that are benign to the body. This general strategy for will be demonstrated in eyes with a view to detection and treating the eye disease uveitis.
DsbA Foldases From Multidrug Resistant Pathogens As Targets For New Antimicrobials
Funder
National Health and Medical Research Council
Funding Amount
$743,401.00
Summary
Bacteria that cause common human infections, such as cystitis and diarrhoea, are now resistant to many antibiotics. If no action is taken, by 2050 antibiotic resistant infections will kill more people each year than cancer. This project aims to address this global public health crisis by characterising promising new bacterial targets and inhibitors designed to disarm multidrug resistant pathogens. Longer term this work could provide new infection therapies that are urgently needed.