DYRK1A As A Novel Target For Glioblastoma Therapies
Funder
National Health and Medical Research Council
Funding Amount
$620,294.00
Summary
Glioblastoma is a form of brain cancer that is currently incurable. We have discovered that switching-off an enzyme called DYRK1A (using ‘DYRK1A inhibitors’) kills glioblastoma cells. This therapeutic advantage is even greater when combined with drugs approved for other cancers. This project will develop new DYRK1A inhibitors and examine a novel combination treatment for glioblastoma patients. This could initiate a novel therapy that could significantly extend patients’ lives.
Performance and image enhancing drug injecting in Australia. This project aims to research the use of performance and image-enhancing drugs (PIED), to understand the associated social practices and to assess what health information PIED injectors need. PIEDs use is increasing in Australia and is associated with serious health issues, including the transmission of blood-borne viruses, especially hepatitis C (HCV). Little is known about PIED injecting and the nation's harm reduction framework is u ....Performance and image enhancing drug injecting in Australia. This project aims to research the use of performance and image-enhancing drugs (PIED), to understand the associated social practices and to assess what health information PIED injectors need. PIEDs use is increasing in Australia and is associated with serious health issues, including the transmission of blood-borne viruses, especially hepatitis C (HCV). Little is known about PIED injecting and the nation's harm reduction framework is unprepared to meet the problems it poses. This project expects to directly inform policy and practice, potentially averting an epidemic of HCV in this population, and aims to minimise HCV transmission among people who inject PIEDs.Read moreRead less
Impediments to uptake and diffusion of take-home naloxone. This project aims to investigate impediments to uptake of ‘take-home’ naloxone (THN), which reverses opioid overdose. Opioid overdose is a major health and social problem in Australia. Programmes to provide opioid consumers with THN to reverse overdose exist in some Australian cities, but uptake in Australia remains minimal. The reasons for this are not well understood. This project will interview opioid consumers, prescribers and pharma ....Impediments to uptake and diffusion of take-home naloxone. This project aims to investigate impediments to uptake of ‘take-home’ naloxone (THN), which reverses opioid overdose. Opioid overdose is a major health and social problem in Australia. Programmes to provide opioid consumers with THN to reverse overdose exist in some Australian cities, but uptake in Australia remains minimal. The reasons for this are not well understood. This project will interview opioid consumers, prescribers and pharmacists to better understand THN, and produce an online resource on experiences of overdose and THN. The aim is to inform those affected by overdose, professionals and the wider Australian community about THN, to support THN distribution, save lives and protect communities.Read moreRead less
Experiences of addiction, treatment and recovery: An online resource for members of the public, health professionals and policymakers. Alcohol and other drug addiction is a major health and social issue in Australia. Treatment success rates are modest and little is known about how people experience and manage addiction and the stigma that accompanies it. This project will generate new knowledge on alcohol and other drug addiction by applying a proven qualitative methodology to these issues for t ....Experiences of addiction, treatment and recovery: An online resource for members of the public, health professionals and policymakers. Alcohol and other drug addiction is a major health and social issue in Australia. Treatment success rates are modest and little is known about how people experience and manage addiction and the stigma that accompanies it. This project will generate new knowledge on alcohol and other drug addiction by applying a proven qualitative methodology to these issues for the first time. It will produce an effective, innovative online resource for affected Australians, their family and friends, and the wider Australian community including health professionals and policymakers.Read moreRead less
Belonging and sexual citizenship among gender and sexual minority youth. In the context of well-documented threats to the mental health and well-being of minority young people, this project will examine the experiences of two different generations of gender and sexual minority youth growing up in Australia, and the sources of support they have found most useful. Innovative contextual analysis will involve documentary and archival research alongside individual and group interviews. Through a focu ....Belonging and sexual citizenship among gender and sexual minority youth. In the context of well-documented threats to the mental health and well-being of minority young people, this project will examine the experiences of two different generations of gender and sexual minority youth growing up in Australia, and the sources of support they have found most useful. Innovative contextual analysis will involve documentary and archival research alongside individual and group interviews. Through a focus on the promotion of well-being and participatory citizenship in a rapidly changing social world, the findings aim to contribute new theory concerning transitions from youth to adulthood, improved methodology for the study of marginal and sometimes hard-to-reach populations, and better quality policy and practice.Read moreRead less
Analysing and comparing concepts of addiction for improved social and health outcomes in Australia. Australia invests heavily in responding to alcohol and other drug (AOD) use. This project will analyse a key concept shaping AOD responses, namely addiction. The analysis will help develop new, more productive approaches to AOD prevention, education and treatment, contributing to improved AOD-related social and health outcomes.
Changing children’s chances: Exploring pathways to developmental inequities. This project aims to investigate the causes of health and developmental inequities between Australian children. Inequities are increasingly observed in Australian children’s physical health, social and emotional wellbeing, and academic learning. Such inequities are unjust, unnecessary and potentially preventable. This project aims to understand the pathways leading to these inequities by examining the many contexts in w ....Changing children’s chances: Exploring pathways to developmental inequities. This project aims to investigate the causes of health and developmental inequities between Australian children. Inequities are increasingly observed in Australian children’s physical health, social and emotional wellbeing, and academic learning. Such inequities are unjust, unnecessary and potentially preventable. This project aims to understand the pathways leading to these inequities by examining the many contexts in which children and their families live and grow. Through a series of innovative analyses using existing data, the project aims to identify potentially modifiable factors at the child, family, school, and community level that contribute to developmental inequities. Understanding of the most promising leverage points for interventions to reduce inequities for Australian children could be used to inform policy.Read moreRead less
Islands of rocks: geckos as a model system to understand patterns of biodiversity, endemism and speciation in the Kimberley. Australia is renowned for its diversity of lizards, yet a plethora of new "cryptic" gecko species continue to be discovered. The project will densely sample the complex Kimberley to understand the evolution of its geckos, which will shed light on true levels of species diversity and the geological and environmental history of this biodiversity hotspot.
ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the ....ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the whole genome as large inserts in BAC vectors, and build a "golden path" with minimal overlap. We will construct libraries of expressed genes from tammar tissues and array them for use in analysing gene expression.Read moreRead less
Do Exposures Before Conception Influence The Risk Of Asthma In Offspring?
Funder
National Health and Medical Research Council
Funding Amount
$688,586.00
Summary
Asthma and poor lung function are major causes of public health issues. Emerging evidence suggests adverse exposures even before the conception of a child may cause these conditions. The proposed project is part of an international study across generations to identify these factors. This study will provide novel evidence to guide interventions and identify studies to advance this area further. These original findings will be of great importance both nationally and internationally.