Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
The origins of electroreception and nocturnality in the earliest known jawed vertebrates and their bearing on vertebrate diversification. This project aims to discover primary new data to pinpoint the timing, anatomical origins and phylogenetic significance when two key sensory systems first appeared in modern vertebrates: electroreception and specialised nocturnal vision. Such abilities today allow high diversity of vertebrates to co-exist within the same geographical range, for example on trop ....The origins of electroreception and nocturnality in the earliest known jawed vertebrates and their bearing on vertebrate diversification. This project aims to discover primary new data to pinpoint the timing, anatomical origins and phylogenetic significance when two key sensory systems first appeared in modern vertebrates: electroreception and specialised nocturnal vision. Such abilities today allow high diversity of vertebrates to co-exist within the same geographical range, for example on tropical reefs or rainforest communities, through careful temporal niche partitioning where reliance on other sensory systems takes over from vision and olfaction as the principal method of prey detection. This project aims to elucidate how the modern fish diversity was shaped by such significant early evolutionary events.Read moreRead less
Gender, family conflict, and suicide in rural China. The principal outcome of this anthropological study is an understanding of the social and cultural causes of suicide in rural China, achieved through close collaboration with Chinese researchers. This will enhance cross-cultural awareness and build cooperative institutional ties with China, both of which are crucial to Australia's development and security in the region. The project will make a major contribution to a global re-conceptualisatio ....Gender, family conflict, and suicide in rural China. The principal outcome of this anthropological study is an understanding of the social and cultural causes of suicide in rural China, achieved through close collaboration with Chinese researchers. This will enhance cross-cultural awareness and build cooperative institutional ties with China, both of which are crucial to Australia's development and security in the region. The project will make a major contribution to a global re-conceptualisation of suicide as a social, as well as a mental health problem, and will raise the profile of Australian institutions in suicide studies, gender studies, anthropology, and Asian studies. Through postgraduate training, the project will also help build much-needed research capacity.Read moreRead less
Resolving evolutionary problems at the fish-tetrapod transition. The project aims to investigate very early Australian tetrapod trackways and conduct fieldwork to resolve the place of origin and timing of the evolution of the first tetrapods. The evolution of fishes to tetrapods was one of the key events in evolution. Studies on Northern Hemisphere fossils place an origin for the group around 380 million years ago. Australian fossils suggest a much older origin. New micro computed tomography dat ....Resolving evolutionary problems at the fish-tetrapod transition. The project aims to investigate very early Australian tetrapod trackways and conduct fieldwork to resolve the place of origin and timing of the evolution of the first tetrapods. The evolution of fishes to tetrapods was one of the key events in evolution. Studies on Northern Hemisphere fossils place an origin for the group around 380 million years ago. Australian fossils suggest a much older origin. New micro computed tomography data from Australian 3-D fossil fishes, combined with study of rare tetrapod gill arch bones, would enable us to determine the origins of tetrapod air-breathing and its ecological setting. The project may facilitate a rewriting of vertebrate evolution's most significant first step.Read moreRead less
Reducing child deaths among the poor in Asian cities: the cultural, social and institutional determinants of child survival. The urban poor experience more, and more variable, child mortality than richer compatriots. Although there are many contributing factors including material poverty, insanitary housing, inaccessible health services, and parental ignorance of good childcare, these do not explain the full extent of the inequities. A key factor is the interest and ability of poor households to ....Reducing child deaths among the poor in Asian cities: the cultural, social and institutional determinants of child survival. The urban poor experience more, and more variable, child mortality than richer compatriots. Although there are many contributing factors including material poverty, insanitary housing, inaccessible health services, and parental ignorance of good childcare, these do not explain the full extent of the inequities. A key factor is the interest and ability of poor households to use their resources, and those of the health services to protect their children's health. This project will use an anthropological-demographic approach in Dhaka and Jakarta to investigate the cultural, social and institutional factors influencing health beliefs and hence treatment decisions at the household level.Read moreRead less
Job quality and the mental health and well-being of working parents and their children. Maximizing workforce participation is a national priority, essential to support an ageing population. Also critical is the full development of children's capabilities; part of a healthy start to life. Jobs, parents, children and family life lie at the centre of these priorities. Although employment supports families financially, this may come at a cost if aspects of the job affect parent well-being, or strain ....Job quality and the mental health and well-being of working parents and their children. Maximizing workforce participation is a national priority, essential to support an ageing population. Also critical is the full development of children's capabilities; part of a healthy start to life. Jobs, parents, children and family life lie at the centre of these priorities. Although employment supports families financially, this may come at a cost if aspects of the job affect parent well-being, or strains family relationships, which are critical to children's development and well-being. As well as informing industrial relations changes, this project will benefit the twin economic and social policy goals of workforce participation while at the same time supporting the health and well-being of parents and their children.Read moreRead less
Socio-economic determinants of future fertility trends in Australia and other developed countries. Future demographic trends will do much to determine Australia's future. Fertility levels will dominate in deciding population numbers, age structure, and the optimum balance between natural increase and immigration. Current ARC-supported research on the theory of demographic transition provides a paradigm for forecasting likely trends, especially when employed with an existing data bank of findings ....Socio-economic determinants of future fertility trends in Australia and other developed countries. Future demographic trends will do much to determine Australia's future. Fertility levels will dominate in deciding population numbers, age structure, and the optimum balance between natural increase and immigration. Current ARC-supported research on the theory of demographic transition provides a paradigm for forecasting likely trends, especially when employed with an existing data bank of findings on social and demographic interrelations. The research is of great national benefit because even small differences in age structure will impact significantly on the size of the labour force, health services, the support of the aged and taxation levels. Relevant policy decisions will need to be made in the near future.Read moreRead less
Improving Government Policy Making and Needs-Based Delivery of Services: Innovative Techniques to Enhance Administrative Data by Adding Socioeconomic Status. This project will create major national benefits by illuminating whether there are significant differences in access to or usage of such key government services as health and education by socio-economic status. Currently, most departments do not fully exploit their administrative data to answer such questions, because of the difficulty of ....Improving Government Policy Making and Needs-Based Delivery of Services: Innovative Techniques to Enhance Administrative Data by Adding Socioeconomic Status. This project will create major national benefits by illuminating whether there are significant differences in access to or usage of such key government services as health and education by socio-economic status. Currently, most departments do not fully exploit their administrative data to answer such questions, because of the difficulty of identifying the socio-economic status of users. This project will help Australia in its on-going but recently intensified efforts to make better use of its administrative data, resulting in a more efficient use of our data resources; better targeting of scare government resources; and improved identification of those in greatest need. Read moreRead less
Interactive Demographic Transition: Analysis and Theory. The demographic transition, or decline in mortality and fertility levels to produce the modern small family and normally long-lived individuals, may well be the most important social change of our time. It has occasioned much research but theory is still in disarray. This is at least partly explained by a disregard for feed-back mechanisms in the form of organized movements supporting and opposing such demographic change. My aim is to r ....Interactive Demographic Transition: Analysis and Theory. The demographic transition, or decline in mortality and fertility levels to produce the modern small family and normally long-lived individuals, may well be the most important social change of our time. It has occasioned much research but theory is still in disarray. This is at least partly explained by a disregard for feed-back mechanisms in the form of organized movements supporting and opposing such demographic change. My aim is to reanalyze data from my own and others? work, taking such interactions into account, to produce a demographic transition theory suited both to historical explanation and the guidance of contemporary policy.Read moreRead less
Special Research Initiatives - Grant ID: SR0354852
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Sustainable Regions for a Competitive Australia. How can metropolitan, rural and remote regions balance economic and job growth, with environmental and social sustainability? This Initiative establishes a Network of researchers to work collaboratively on questions of environmental best practice, community development, regional governance, labour markets, economic development and technology transfer. The Network's vision is to find ways to use existing and future research to help make Australia ....Sustainable Regions for a Competitive Australia. How can metropolitan, rural and remote regions balance economic and job growth, with environmental and social sustainability? This Initiative establishes a Network of researchers to work collaboratively on questions of environmental best practice, community development, regional governance, labour markets, economic development and technology transfer. The Network's vision is to find ways to use existing and future research to help make Australia's regions more competitive on world markets and more environmentally sustainable, and to help build stronger regional communities. The Network cuts across traditional discipline boundaries to find integrated solutions to the real problems confronting Australian regions.Read moreRead less