DYRK1A As A Novel Target For Glioblastoma Therapies
Funder
National Health and Medical Research Council
Funding Amount
$620,294.00
Summary
Glioblastoma is a form of brain cancer that is currently incurable. We have discovered that switching-off an enzyme called DYRK1A (using ‘DYRK1A inhibitors’) kills glioblastoma cells. This therapeutic advantage is even greater when combined with drugs approved for other cancers. This project will develop new DYRK1A inhibitors and examine a novel combination treatment for glioblastoma patients. This could initiate a novel therapy that could significantly extend patients’ lives.
The origins of electroreception and nocturnality in the earliest known jawed vertebrates and their bearing on vertebrate diversification. This project aims to discover primary new data to pinpoint the timing, anatomical origins and phylogenetic significance when two key sensory systems first appeared in modern vertebrates: electroreception and specialised nocturnal vision. Such abilities today allow high diversity of vertebrates to co-exist within the same geographical range, for example on trop ....The origins of electroreception and nocturnality in the earliest known jawed vertebrates and their bearing on vertebrate diversification. This project aims to discover primary new data to pinpoint the timing, anatomical origins and phylogenetic significance when two key sensory systems first appeared in modern vertebrates: electroreception and specialised nocturnal vision. Such abilities today allow high diversity of vertebrates to co-exist within the same geographical range, for example on tropical reefs or rainforest communities, through careful temporal niche partitioning where reliance on other sensory systems takes over from vision and olfaction as the principal method of prey detection. This project aims to elucidate how the modern fish diversity was shaped by such significant early evolutionary events.Read moreRead less
Analysing gender in research and policy on alcohol-related violence. This project aims to provide insights into gendered aspects of research and policy on alcohol-related violence among young people. It will produce knowledge through a comparative approach encompassing key alcohol policy contexts in Australia, Canada and Sweden. Project outcomes will improve the capacity of health and policy practitioners to understand the relationships between gender, alcohol and violence; reconceptualise resp ....Analysing gender in research and policy on alcohol-related violence. This project aims to provide insights into gendered aspects of research and policy on alcohol-related violence among young people. It will produce knowledge through a comparative approach encompassing key alcohol policy contexts in Australia, Canada and Sweden. Project outcomes will improve the capacity of health and policy practitioners to understand the relationships between gender, alcohol and violence; reconceptualise responses to alcohol-related problems; inform the development of future alcohol research and policy; increase the capacity to respond more effectively to alcohol use; and reduce alcohol-related harm.Read moreRead less
Performance and image enhancing drug injecting in Australia. This project aims to research the use of performance and image-enhancing drugs (PIED), to understand the associated social practices and to assess what health information PIED injectors need. PIEDs use is increasing in Australia and is associated with serious health issues, including the transmission of blood-borne viruses, especially hepatitis C (HCV). Little is known about PIED injecting and the nation's harm reduction framework is u ....Performance and image enhancing drug injecting in Australia. This project aims to research the use of performance and image-enhancing drugs (PIED), to understand the associated social practices and to assess what health information PIED injectors need. PIEDs use is increasing in Australia and is associated with serious health issues, including the transmission of blood-borne viruses, especially hepatitis C (HCV). Little is known about PIED injecting and the nation's harm reduction framework is unprepared to meet the problems it poses. This project expects to directly inform policy and practice, potentially averting an epidemic of HCV in this population, and aims to minimise HCV transmission among people who inject PIEDs.Read moreRead less
Impediments to uptake and diffusion of take-home naloxone. This project aims to investigate impediments to uptake of ‘take-home’ naloxone (THN), which reverses opioid overdose. Opioid overdose is a major health and social problem in Australia. Programmes to provide opioid consumers with THN to reverse overdose exist in some Australian cities, but uptake in Australia remains minimal. The reasons for this are not well understood. This project will interview opioid consumers, prescribers and pharma ....Impediments to uptake and diffusion of take-home naloxone. This project aims to investigate impediments to uptake of ‘take-home’ naloxone (THN), which reverses opioid overdose. Opioid overdose is a major health and social problem in Australia. Programmes to provide opioid consumers with THN to reverse overdose exist in some Australian cities, but uptake in Australia remains minimal. The reasons for this are not well understood. This project will interview opioid consumers, prescribers and pharmacists to better understand THN, and produce an online resource on experiences of overdose and THN. The aim is to inform those affected by overdose, professionals and the wider Australian community about THN, to support THN distribution, save lives and protect communities.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130101660
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
The secret of bee navigation: magnetic field sensitive cells in the honeybee Apis mellifera. Honeybees are known to use the Earth's geomagnetic field to orient themselves and carry out their vital role as crop pollinators and honey producers. Locating and characterising the cells responsible for this magnetic sense is of great significance to neuroscience and will provide important new insights into animal behaviour and ecology.
Lived experiences of treatment for hepatitis C in Australia. This project aims to support uptake of new hepatitis C treatments. With the introduction of new treatments in 2016, the Australian Government adopted the WHO’s goal of eliminating the disease by 2030. While early treatment rates were high, they have since plateaued, with stigma and poor information considered key obstacles. This project will generate new knowledge on treatment decisions and experiences, using a proven qualitative metho ....Lived experiences of treatment for hepatitis C in Australia. This project aims to support uptake of new hepatitis C treatments. With the introduction of new treatments in 2016, the Australian Government adopted the WHO’s goal of eliminating the disease by 2030. While early treatment rates were high, they have since plateaued, with stigma and poor information considered key obstacles. This project will generate new knowledge on treatment decisions and experiences, using a proven qualitative methodology. In doing so, it will produce a website covering personal experiences of treatment, issues in treatment decision-making, and advice on enhancing life on treatment and after. It will tackle hepatitis C-related stigma, and inform and benefit potential treatment users, families and relevant professionals.
Read moreRead less
Experiences of addiction, treatment and recovery: An online resource for members of the public, health professionals and policymakers. Alcohol and other drug addiction is a major health and social issue in Australia. Treatment success rates are modest and little is known about how people experience and manage addiction and the stigma that accompanies it. This project will generate new knowledge on alcohol and other drug addiction by applying a proven qualitative methodology to these issues for t ....Experiences of addiction, treatment and recovery: An online resource for members of the public, health professionals and policymakers. Alcohol and other drug addiction is a major health and social issue in Australia. Treatment success rates are modest and little is known about how people experience and manage addiction and the stigma that accompanies it. This project will generate new knowledge on alcohol and other drug addiction by applying a proven qualitative methodology to these issues for the first time. It will produce an effective, innovative online resource for affected Australians, their family and friends, and the wider Australian community including health professionals and policymakers.Read moreRead less
The Identification Of Thoracic Targets For Prevention And Intervention In Bronchopulmonary Dysplasia
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
The persistence of breathing problems from infancy to later life is a complication of premature birth with lifelong consequences. Breathing problems often occur together with lung disease, but prematurity can also affect heart and blood vessel development, and weakness of the main breathing muscle. We will find out how much the heart, lungs and diaphragm contribute to breathing problems in babies; helping us to better predict, diagnose and treat severe breathing problems in babies born preterm.
Survival and growth of children in rural East Timor: the influences of family structure, resources and local environment on child outcomes. Families can moderate or exacerbate ecological challenges to child survival and growth. Rural families must balance labour needs with consumption and are challenged by unexpected environmental changes. The project will assess the characteristics of rural East Timorese families that are associated with positive outcomes in child survival and growth.