Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
Violence Against Women - A Media Intervention. This project aims to by explore the link between the internal operations of news media organisations, news media outputs and their impact on community attitudes to violence against women. Current literature indicates that the paucity and tone of news reporting of violence against women perpetuates harmful attitudes towards women. International and Australian research has consistently identified community attitudes as a key causal factor in violence ....Violence Against Women - A Media Intervention. This project aims to by explore the link between the internal operations of news media organisations, news media outputs and their impact on community attitudes to violence against women. Current literature indicates that the paucity and tone of news reporting of violence against women perpetuates harmful attitudes towards women. International and Australian research has consistently identified community attitudes as a key causal factor in violence against women. However, there is a lack of research into the impact of newsroom operations, including gender politics, on news media outputs, and the impact of those outputs on community attitudes. The proposed research and intervention project seek to address this shortfall.Read moreRead less
How Australians navigate the healthcare maze: the differential capacity to choose. This project answers the question: how do Australians make choices as they navigate the healthcare maze? An examination of policy, media and marketing materials, and interviews with health professionals and consumers across three Australian states will reveal the most important factors in the capacity to exercise healthcare choice in Australia.
Male sex workers and their clients. This project aims to study male sex workers’ relationships with their clients to evaluate how individual agency mitigates risks and dangers. Developments in biomedical HIV prevention can prevent infections but may also change sexual norms and the sexual marketplace for male sex workers and their clients. These changes align with rising rates of crystal methamphetamine use and online technologies in commercial sex encounters. As male sex work changes, a gap exi ....Male sex workers and their clients. This project aims to study male sex workers’ relationships with their clients to evaluate how individual agency mitigates risks and dangers. Developments in biomedical HIV prevention can prevent infections but may also change sexual norms and the sexual marketplace for male sex workers and their clients. These changes align with rising rates of crystal methamphetamine use and online technologies in commercial sex encounters. As male sex work changes, a gap exists in understanding how men negotiate commercial sex encounters. This project expects to inform policies and practices to protect male sex workers’ health and safety, and provide public health information about HIV prevention and illicit drug use in sex work.Read moreRead less
A framework to promote safer practice in commercial sex encounters. The project will address public health needs by producing a framework to promote safer sex practices in commercial sexual encounters involving men, by considering the motivation and practice of those involved. It will also enhance our understanding of masculinity.
Benefit Of 2D-strain Surveillance In Improving Cardiovascular Outcomes In Cancer Patients Undergoing Cardiotoxic Chemotherapy
Funder
National Health and Medical Research Council
Funding Amount
$2,391,979.00
Summary
Cancer survivors are susceptible to heart failure (HF) caused by heart muscle damage from chemotherapy. The current testing for this problem is based on a measure that cannot identify minor changes of cardiac function. Cardiac strain is a sensitive new marker of cardiac function which is predictive of overt dysfunction & HF. This study seeks to identify whether strain can be used to assign treatments that lead to improved cardiac function and are eventually associated with a reduction in HF.
Mobile Indonesians: social differentiation and digital literacies in the twenty first century. This is the first dedicated study of the social implications of mobile telephony's recent and rapid popularisation throughout the country. This project will study metropolitan, urban and rural users to understand how mobile phones create the new and unexpected social networks which will shape tomorrow's Indonesians.
Bayesian methodology for analysis of genome data with focus on the livestock industry. The aim is to develop statistical methods for the design and analysis of genome data with focus on the special needs of the livestock industry. This will significantly contribute to profitability, quality, genetic improvement and genetic knowledge in a key national industry, improve Australia's international and national profile in the key research area of bioinformatics, and encourage optimisation of current ....Bayesian methodology for analysis of genome data with focus on the livestock industry. The aim is to develop statistical methods for the design and analysis of genome data with focus on the special needs of the livestock industry. This will significantly contribute to profitability, quality, genetic improvement and genetic knowledge in a key national industry, improve Australia's international and national profile in the key research area of bioinformatics, and encourage optimisation of current information. Outcomes include a toolkit of applicable statistical methods, statistically valid algorithms, marketable methods for gene discovery, technology transfer, training and publications.Read moreRead less
Bridging the gap on locational disadvantage: Impact of community-identified interventions on social capital, psychosocial and socioeconomic outcomes. Interventions to combat locational disadvantage are vital given the pervasiveness and long-term consequences for youth and communities. This research will offer important educational and socio-economic benefits by enriching the psychosocial adjustment and life potential of young Australians and the capacity of schools in locationally disadvantaged ....Bridging the gap on locational disadvantage: Impact of community-identified interventions on social capital, psychosocial and socioeconomic outcomes. Interventions to combat locational disadvantage are vital given the pervasiveness and long-term consequences for youth and communities. This research will offer important educational and socio-economic benefits by enriching the psychosocial adjustment and life potential of young Australians and the capacity of schools in locationally disadvantaged communities. Effective research and community-identified social capital and psychosocial interventions will enhance pro-social behaviours, health, psychosocial adjustment, and school and community engagement. This will build capacity at community, school, and individual levelsand contribute to national socioeconomic wellbeing.Read moreRead less