Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
Optimising the spring in your step to enhance footwear design. This project aims to examine how the nervous system adjusts the mechanical function of our feet across a spectrum of speeds, from slow running through to maximal effort sprinting. The proposed research will explore how the nervous system controls the function of the foot to meet the ever-varying demands of locomotion in the real-world. Expected outcomes of this project are to determine if running shoes help or hinder the natural spri ....Optimising the spring in your step to enhance footwear design. This project aims to examine how the nervous system adjusts the mechanical function of our feet across a spectrum of speeds, from slow running through to maximal effort sprinting. The proposed research will explore how the nervous system controls the function of the foot to meet the ever-varying demands of locomotion in the real-world. Expected outcomes of this project are to determine if running shoes help or hinder the natural spring-like function of the foot. It will explain a conceptually novel design allowing shoes to support our feet, whilst harnessing the energetic benefits of the foot's spring-like function. This research has the potential to revolutionise athletic footwear design and has direct implications for enhanced performance in running athletes.Read moreRead less
ARC Centre of Excellence for Automated Decision-Making and Society. The ARC CoE for Automated Decision-Making and Society aims to create the knowledge and strategies necessary for responsible, ethical, and inclusive automated decision-making (ADM). ADM applies new technologies from machine learning to blockchains across a wide range of social sectors; it carries great potential and risks serious failures. The Centre combines social and technological disciplines in an international industry, rese ....ARC Centre of Excellence for Automated Decision-Making and Society. The ARC CoE for Automated Decision-Making and Society aims to create the knowledge and strategies necessary for responsible, ethical, and inclusive automated decision-making (ADM). ADM applies new technologies from machine learning to blockchains across a wide range of social sectors; it carries great potential and risks serious failures. The Centre combines social and technological disciplines in an international industry, research and civil society network. It will formulate world-leading policy and practice; inform public debate; and train a new generation of researchers and practitioners. Expected benefits include reduced risks and improved outcomes in the priority domains of news and media, transport, social services and health.Read moreRead less
Alcohol’s harm to others: patterns, costs, disparities and precipitants. This project aims to generate understanding of the magnitude, character, economic burden, disparities and precipitants of occurrence of alcohol’s harm to others across Australia, using a national survey, crime, community services and health data and qualitative interviews. The project outcome will be a robust current evidence base for our partners, government and Australian society to underpin advocacy, policy and planning, ....Alcohol’s harm to others: patterns, costs, disparities and precipitants. This project aims to generate understanding of the magnitude, character, economic burden, disparities and precipitants of occurrence of alcohol’s harm to others across Australia, using a national survey, crime, community services and health data and qualitative interviews. The project outcome will be a robust current evidence base for our partners, government and Australian society to underpin advocacy, policy and planning, aimed at reducing alcohol-related harm and suffering.Read moreRead less
Mobile Indonesians: social differentiation and digital literacies in the twenty first century. This is the first dedicated study of the social implications of mobile telephony's recent and rapid popularisation throughout the country. This project will study metropolitan, urban and rural users to understand how mobile phones create the new and unexpected social networks which will shape tomorrow's Indonesians.
Valuing News: Aligning Individual, Institutional and Societal Perspectives. This project aims to identify the links between the preparedness of individuals to pay for news, the value of news brands and organisational cultures of news publishers, and the social value of news in promoting a democratic public sphere. Its significance arises with the ongoing crisis of news media business models, which is raising new questions about the future of journalism, and the changing role of governments worl ....Valuing News: Aligning Individual, Institutional and Societal Perspectives. This project aims to identify the links between the preparedness of individuals to pay for news, the value of news brands and organisational cultures of news publishers, and the social value of news in promoting a democratic public sphere. Its significance arises with the ongoing crisis of news media business models, which is raising new questions about the future of journalism, and the changing role of governments worldwide in financing news production. Its expected outcomes include advancing debates about how to support public interest journalism, and the value of news as both a commodity and a public good. It will be of benefit to industry, policymakers and the community in addressing the prospects for Australian journalism. Read moreRead less
ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial ....ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial concepts into statistical analysis and modelling, powerful visualisation of information, and the building spatial decision support systems, to provide an improved evidence base and better informed decision-making to address the significant challenges facing Australia's people and its places.Read moreRead less
Confronting everyday harms: preventing abuse of people with disability. The findings of the Disability Royal Commission necessitate new approaches to prevent violence, abuse, neglect and exploitation. Framed by recognition theory, this project proposes empirical research with young people with cognitive disability, using a new concept of ‘everyday harms’ in their paid relationships. The results will inform early responses to poor quality interactions in disability support. The strategic alliance ....Confronting everyday harms: preventing abuse of people with disability. The findings of the Disability Royal Commission necessitate new approaches to prevent violence, abuse, neglect and exploitation. Framed by recognition theory, this project proposes empirical research with young people with cognitive disability, using a new concept of ‘everyday harms’ in their paid relationships. The results will inform early responses to poor quality interactions in disability support. The strategic alliances with the government, industry and community partners will develop a practice framework to prevent everyday harms and the escalation to abuse, and to promote safety and wellbeing. The research has policy benefits for capacity-building in the sector to act on the rights and voices of people with disability. Read moreRead less
Urban Imaginaries/Cultural Landscapes: An Asia-Pacific Transnational and Cross-Cultural Research Collaboration. The aim of the program is to foster research collaboration between the ANU's Humanities Research Centre and Lingnan University's Cultural Research and Development Program by examining public culture, transnational culture, urban landscapes and urban cultural identities in the contemporary Asia-Pacific and Australian context. We will do this by extending ties with researchers from the ....Urban Imaginaries/Cultural Landscapes: An Asia-Pacific Transnational and Cross-Cultural Research Collaboration. The aim of the program is to foster research collaboration between the ANU's Humanities Research Centre and Lingnan University's Cultural Research and Development Program by examining public culture, transnational culture, urban landscapes and urban cultural identities in the contemporary Asia-Pacific and Australian context. We will do this by extending ties with researchers from the region including early career and students and by developing a comparative cross-cultural methodology capable of encompassing specific socio-historical patterns and processes of dynamically changing public cultural formations in contemporary urban centres in the Asia-Pacific, including Australia. Specific outcomes include a book, e-journal and a multi-media exhibition.
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The rise of mistrust: Digital platforms and trust in news media. This project aims to investigate how trust and mistrust in news changes audiences’ behaviours as they increasingly access news through digital platforms. Observing the global crisis of trust, the project will undertake a longitudinal analysis of trust and mistrust in news, a four-country experiment that links trust and audience responses, and an in-depth qualitative study that provides specific contexts of these choices. The resear ....The rise of mistrust: Digital platforms and trust in news media. This project aims to investigate how trust and mistrust in news changes audiences’ behaviours as they increasingly access news through digital platforms. Observing the global crisis of trust, the project will undertake a longitudinal analysis of trust and mistrust in news, a four-country experiment that links trust and audience responses, and an in-depth qualitative study that provides specific contexts of these choices. The research will directly benefit policy makers, as it addresses questions of how to better secure trustworthy news content in an age of increasing dominance of digital platforms that algorithmically sort the range of news available to the Australian public.
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