Targeting Fungal Phospholipid Metabolism For Antifungal Drug Discovery
Funder
National Health and Medical Research Council
Funding Amount
$828,557.00
Summary
Invasive fungal infections are a serious and escalating health problem. They cause severe disease with a high death rate and are very costly to the health system. New antifungal drugs with novel properties are needed now because there are problems with current drugs. This project aims to develop potent new antifungal drugs that are effective in many fungal diseases and are well-tolerated.
How Do Thick Airway Walls Affect Airway Hyperresponsiveness In Asthma?
Funder
National Health and Medical Research Council
Funding Amount
$382,538.00
Summary
Asthmatic airways narrow too easily, a characteristic called airway hyperresponsiveness (AHR). To understand the cause of asthma we need to understand the cause of AHR. Thickened airway walls could amplify airway narrowing and increase AHR. However, thick airway walls are also stiff, and stiff walls could reduce narrowing and AHR. This project will examine the relationships between AHR and airway wall thickness and stiffness during and after treatment that reduces airway wall thickness.
A Multicentre Randomised Clinical Trial Of Physical Activity For The Treatment Of Patients With Alzheimers Disease
Funder
National Health and Medical Research Council
Funding Amount
$773,752.00
Summary
The number of older adults living with Alzheimer's disease (AD) will increase from 26.6 million to 106.2 million by 2050. In the absence of curative treatment options it is important to focus on non-pharmacological interventions such as physical activity. We propose to investigate whether a home-based physical activity program of 24 weeks for patients with AD can successfully decrease the rate of cognitive and functional declince and improve quality of life and psychological well-being.
Predictors And Correlates Of Health-related Quality Of Life And Morbidity In Overweight/obese Adolescents: Cohort Study
Funder
National Health and Medical Research Council
Funding Amount
$512,525.00
Summary
There is now no doubting the size and long-term risks to health of the childhood obesity epidemic. However, very little research has examined at population level its immediate consequences for mental health and physical functioning, what pathways confer risk and protection for these consequences, and their likely healthcare consequences. This study will utilise an existing cohort of approximately 1500 Victorian adolescents followed since childhood to examine neglected aspects of the genesis and ....There is now no doubting the size and long-term risks to health of the childhood obesity epidemic. However, very little research has examined at population level its immediate consequences for mental health and physical functioning, what pathways confer risk and protection for these consequences, and their likely healthcare consequences. This study will utilise an existing cohort of approximately 1500 Victorian adolescents followed since childhood to examine neglected aspects of the genesis and impacts of overweight and obesity. The Health of Young Victorians Study was originally assembled in 1997 when the children were in Grades Prep-3. In addition to information on putative risk and protective factors for overweight-obesity and direct measures of height and weight, it is unique in having collected data on health-related quality of life (HRQoL) since children were first recruited during the early primary school years. Eight years after the first wave, the children will be adolescents in Grades 8-11. This third wave will retain a focus on HRQoL. Innovations include study of potential emotional, behavioural and physical consequences of childhood obesity that may in turn affect the natural history of obesity. This large, population-based longitudinal study will redress neglected aspects of child and adolescent overweight-obesity specifically identified in 2003 by the NH and MRC. As well as establishing whether a range of common problems are related to overweight-obesity, it will be able to shed light on mechanisms of adverse outcomes associated with adolescent overweight-obesity, and study protective factors predicting remitting overweight from childhood to adolescence that may inform preventive activities. The study will make an international contribution to knowledge about pathways, prevalence and preventive opportunities for child and adolescent overweight-obesity.Read moreRead less
Assessing Sustainability Of Positive Outcomes In A Successful Child Obesity Prevention Intervention: Follow-up Of The Melbourne InFANT Program
Funder
National Health and Medical Research Council
Funding Amount
$882,700.00
Summary
Early intervention may be the most sustainable and effective means of preventing obesity and promoting healthy lifestyle behaviours (obesity preventive behaviours) including diet, physical activity and reduced sedentary behaviours. This project aims to assess whether differences observed between intervention and control groups at the conclusion of a successful obesity prevention program, the Melbourne InFANT Program, (child aged 18-months) are maintained across the important early childhood year ....Early intervention may be the most sustainable and effective means of preventing obesity and promoting healthy lifestyle behaviours (obesity preventive behaviours) including diet, physical activity and reduced sedentary behaviours. This project aims to assess whether differences observed between intervention and control groups at the conclusion of a successful obesity prevention program, the Melbourne InFANT Program, (child aged 18-months) are maintained across the important early childhood years, to 3.5 and 5 years of age.Read moreRead less
TELEPHONE COUNSELLING FOR MAINTENANCE OF PHYSICAL ACTIVITY, WEIGHT LOSS And GLYCAEMIC CONTROL IN TYPE 2 DIABETES
Funder
National Health and Medical Research Council
Funding Amount
$1,285,894.00
Summary
Regular exercise, a healthy diet and weight loss are key to managing type 2 diabetes, yet these are major challenges for most people with diabetes. This study will evaluate the impact of a telephone counselling program to assist people with type 2 diabetes to exercise, eat a healthy diet and lose weight, with the goal of helping them to sustain these changes over the long-term. It is expected that these lifestyle changes will also result in improved blood glucose control and quality of life.
UTILITY OF NOVEL BIOMARKERS IN THE PREDICTION OF MAJOR COMPLICATIONS OF TYPE II DIABETES MELLITUS
Funder
National Health and Medical Research Council
Funding Amount
$510,639.00
Summary
Diabetes is increasingly common. It can cause a variety of complications, the most serious being heart and kidney disease. The reasons why some patients develop such complications are not fully understood so it is difficult to predict who will be affected. The current project will use samples from a large international study of patients with diabetes to assess whether levels of specific markers in the blood help to predict major complications and clarify why they occur.
An RCT To Promote Healthy Lifestyle Behaviours From Infancy: An Intervention To Prevent Childhood Overweight
Funder
National Health and Medical Research Council
Funding Amount
$578,631.00
Summary
In Australia, one in four school-aged children is currently overweight and childhood obesity rates are continuing to rise. In the last five years it has become clear that rates of overweight and obesity are also rapidly increasing in pre-school age children. These are issues that are of concern to health officials as well as to parents. We understand that these rising rates in fatness relate to children's diet and activity patterns, and that these patterns, once established are likely to be patt ....In Australia, one in four school-aged children is currently overweight and childhood obesity rates are continuing to rise. In the last five years it has become clear that rates of overweight and obesity are also rapidly increasing in pre-school age children. These are issues that are of concern to health officials as well as to parents. We understand that these rising rates in fatness relate to children's diet and activity patterns, and that these patterns, once established are likely to be patterns for life. To date, there has been relatively little research regarding the chance to support parents to establish the eating and activity patterns that will protect their children from the very beginning of life. This project seeks to support first-time parents to establish healthy eating and activity behaviours in their children using the highly utilised Maternal and Child Health Centres first time parents' groups. We believe that these groups will provide a strongly supportive environment in which to provide parents with strategies and knowledge for promoting healthy eating and activity patterns for their children, and in turn, promote healthy weight gain. This project will assess the effectiveness of this intervention.Read moreRead less
A Multi-setting Intervention To Reduce Sedentary Behaviour, Promote Physical Activity And Improve Childrens Health
Funder
National Health and Medical Research Council
Funding Amount
$860,343.00
Summary
Sedentary behaviours and physical inactivity play a major role in the rising prevalence of obesity among children in Australia. This intervention study will take place in the school and family settings which play a critical role in shaping children's health behaviours. The objective is to determine whether a 2-year behavioural intervention reduces sedentary behaviour and promotes physical activity and results in improved health among 8-9 year old children.
RCT Of The Impact Of Electronic Game Use By Children On Physical Activity And Energy Expenditure
Funder
National Health and Medical Research Council
Funding Amount
$538,135.00
Summary
Increasing childhood obesity and reduced physical activity are major health issues in Australia. Three quarters of Australian children play electronic games and this is widely thought to reduce their physical activity. Whilst the effect of TV viewing is well understood, the impact of electronic games is not. This study will test whether access to electronic games results in decreased physical activity in children. We need to understand the impact this popular activity is having on child health.