Developing new tools for chemical biology. We will develop new synthetic strategies to support the development of small molecule chemical probes that bind with high affinity and specificity to a target protein. Such chemical probes are invaluable in elucidating the role of specific proteins in biological pathways. Our novel strategy aims to be rapid, efficient in its use of materials and widely applicable to a range of different protein targets. The core of our approach involves using biophysica ....Developing new tools for chemical biology. We will develop new synthetic strategies to support the development of small molecule chemical probes that bind with high affinity and specificity to a target protein. Such chemical probes are invaluable in elucidating the role of specific proteins in biological pathways. Our novel strategy aims to be rapid, efficient in its use of materials and widely applicable to a range of different protein targets. The core of our approach involves using biophysical binding assays to characterise compounds that are produced on small scale using parallel chemistry. This approach will enable better chemical probes to be developed more rapidly at lower cost than is currently possible.Read moreRead less
When caring ends: Understanding and supporting informal care trajectories. This project aims to advance understandings of how, why, when, and for whom caring ends, including the socio-cultural and relational factors that shape experiences before, during, and after caring. Using an innovative, multi-method sociological approach, and foregrounding carers’ voices, this project expects to generate new knowledge on the meaning and experience of care and caring. This project is significant in bringing ....When caring ends: Understanding and supporting informal care trajectories. This project aims to advance understandings of how, why, when, and for whom caring ends, including the socio-cultural and relational factors that shape experiences before, during, and after caring. Using an innovative, multi-method sociological approach, and foregrounding carers’ voices, this project expects to generate new knowledge on the meaning and experience of care and caring. This project is significant in bringing together leading researchers and key carer-focused organisations, spanning service sectors and moving across care relationships, life stages and contexts. Expected outcomes include enhanced service capacity with tangible policy and practice benefits that will enable sustainable and fulfilling informal caring experiences.Read moreRead less
Addressing Evidence Gaps And Developing A Novel Treatment To Reduce The Burden Of Post-traumatic Knee Osteoarthritis
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
Arthritis caused by knee injury has a devastating personal and economic impact. Research is needed to develop strategies to prevent arthritis and improve outcomes for people living with arthritis. This research will improve treatment of knee injury to reduce arthritis risk, understand why some people are more likely to get knee arthritis, and develop a new treatment to improve outcomes for people living with knee arthritis. A clinical trial will determine if this treatment achieves this aim.
How parents manage climate anxiety: coping and hoping for the whole family. This project studies how Australian parents manage climate anxiety for themselves and their families. Using mixed-methods/mixed-media approaches, it examines whether an increase in climate disasters is accelerating the spread of collective anxiety amongst families, how parents manage this anxiety for their children and partners, and if there are associated mental health burdens and gendered inequities in this management. ....How parents manage climate anxiety: coping and hoping for the whole family. This project studies how Australian parents manage climate anxiety for themselves and their families. Using mixed-methods/mixed-media approaches, it examines whether an increase in climate disasters is accelerating the spread of collective anxiety amongst families, how parents manage this anxiety for their children and partners, and if there are associated mental health burdens and gendered inequities in this management. It also looks at climate anxiety management across generations and climate histories, drawing out pessimistic/optimistic narratives about the future to enable action, resilience, and hope. It will produce an evidence base and photo-voice/documentary resources to help parents and support organisations combat climate anxiety.Read moreRead less
The Consequences of the Mental Load for Australian Families. This project aims to investigate the mental load; a structure of household work that combines cognitive and emotional labour. While there are theoretical understandings of the mental load, there is a dearth of quantitative research. This project expects to develop a consistent and reliable measure of the mental load and an understanding of its impacts on Australian families. The expected outcomes of the project include a comprehensive ....The Consequences of the Mental Load for Australian Families. This project aims to investigate the mental load; a structure of household work that combines cognitive and emotional labour. While there are theoretical understandings of the mental load, there is a dearth of quantitative research. This project expects to develop a consistent and reliable measure of the mental load and an understanding of its impacts on Australian families. The expected outcomes of the project include a comprehensive measurement of the mental load both in Australia and abroad. This will allow for the development of policy alleviating its impacts on caregivers, particularly mothers, and assist workplaces and Government in incorporating women into employment to reduce gender inequality.Read moreRead less
Improving Indigenous health and wellbeing over the family life course. Improving Indigenous health and wellbeing over the family life course. This project aims to reduce Indigenous health inequalities, a major social and economic problem, by improving the policy relevant evidence base on the determinants of Indigenous health and wellbeing. This project will compare the impact of the family life course on the health and wellbeing of Indigenous and non-Indigenous mothers and children. It will use ....Improving Indigenous health and wellbeing over the family life course. Improving Indigenous health and wellbeing over the family life course. This project aims to reduce Indigenous health inequalities, a major social and economic problem, by improving the policy relevant evidence base on the determinants of Indigenous health and wellbeing. This project will compare the impact of the family life course on the health and wellbeing of Indigenous and non-Indigenous mothers and children. It will use survey data that follows them over time to: 1) identify family structures that enhance or harm health and wellbeing, and; 2) track changes in health and wellbeing before, during and after family transitions (i.e. births, relationship changes). Anticipated results are better targeted policy interventions to reduce Indigenous health inequalities.Read moreRead less
Enhancing sleep and wellbeing in working families. This project aims to investigate the role of sleep on individuals’ health by measuring Australians' sleep patterns relative to work and family demands. This project expects to generate new knowledge in the sociology of sleep using innovative data collection bringing together cross-national, nationally representative, longitudinal and physiological data on Australians’ sleep patterns. Expected outcomes of this project are to identify the social a ....Enhancing sleep and wellbeing in working families. This project aims to investigate the role of sleep on individuals’ health by measuring Australians' sleep patterns relative to work and family demands. This project expects to generate new knowledge in the sociology of sleep using innovative data collection bringing together cross-national, nationally representative, longitudinal and physiological data on Australians’ sleep patterns. Expected outcomes of this project are to identify the social and biological determinants of sleep and their links with health, family and economic policy recommendations.Read moreRead less
Reducing rocket resonance is the key to safer spaceflight. This fellowship considers a particularly dangerous component of rocket launch, which is the potential for destructive feedback loops to form either in the nozzle, or between the nozzle and the launch pad. CI Edgington-Mitchell is a world leader in the study of resonance in jet engines, having developed best-in-field methodologies for the problem. In this innovative fellowship, he will apply these methodologies to better understand the da ....Reducing rocket resonance is the key to safer spaceflight. This fellowship considers a particularly dangerous component of rocket launch, which is the potential for destructive feedback loops to form either in the nozzle, or between the nozzle and the launch pad. CI Edgington-Mitchell is a world leader in the study of resonance in jet engines, having developed best-in-field methodologies for the problem. In this innovative fellowship, he will apply these methodologies to better understand the dangerous resonances that can occur during rocket launch, using a combination of experimental, numerical, and theoretical techniques, in partnership with NASA, Stanford, and the CNRS.Read moreRead less
The sociology of antibiotics and the antimicrobial resistance crisis. This project aims to investigate the sociological dimensions of antibiotics consumption by examining the views and experiences of clinicians, decision-makers, and members of the general population. The project expects to generate new knowledge about the social aspects of antibiotics use and consumer-provider interactions. Expected outcomes of this project include stronger consumer-provider collaborations about antibiotic use a ....The sociology of antibiotics and the antimicrobial resistance crisis. This project aims to investigate the sociological dimensions of antibiotics consumption by examining the views and experiences of clinicians, decision-makers, and members of the general population. The project expects to generate new knowledge about the social aspects of antibiotics use and consumer-provider interactions. Expected outcomes of this project include stronger consumer-provider collaborations about antibiotic use and a new evidence-base to guide policy decisions. This project should provide significant benefits for the national response to antimicrobial resistance, including enhanced public education and public policy.Read moreRead less
Eruption dynamics and tsunami potential from submarine volcanoes. This project is based on recently acquired seafloor samples and geophysical data from extraordinary deposits at a modern submarine volcano. This project aims to determine the conditions that lead to explosive eruption underwater, the dynamics of associated sediment flows, and if these events can trigger tsunami. Expected outcomes include an unprecedented reconstruction of the architecture of submarine caldera volcanoes, new innova ....Eruption dynamics and tsunami potential from submarine volcanoes. This project is based on recently acquired seafloor samples and geophysical data from extraordinary deposits at a modern submarine volcano. This project aims to determine the conditions that lead to explosive eruption underwater, the dynamics of associated sediment flows, and if these events can trigger tsunami. Expected outcomes include an unprecedented reconstruction of the architecture of submarine caldera volcanoes, new innovative models applicable globally for a richer understanding of volcanic tsunami and eruptions that shape the seafloor. This project will provide significant benefits through mitigation of global marine natural hazards, and by improving knowledge on the volcanic hosts of ore deposits.Read moreRead less