Rapid method development in pharmaceutical analysis using quality-by-design principles. Chemical analysis using separation methods underpins all stages of drug design and analysis. This project will generate new approaches to greatly reduce the time taken to develop a new method of analysis. This will be achieved through development of new computerised techniques for rapid screening, selection and optimisation of analytical methods.
Fragment based screening to deliver drugs targeting tuberculosis and the gametocyte and liver stages of Plasmodium. This project will identify natural products that bind to critical proteins in malaria and tuberculosis to discover new ways to treat these diseases.
Development of molecular markers for resistance to blackleg disease (Leptosphaeria maculans) in canola. Canola (Brassica napus) is a valuable oil seed crop grown in many parts of the world and contributes annually $A450 million to the Australian economy. The overall aim of this project is to develop molecular markers for blackleg resistance using Australian germplasm along with evaluation in Australian disease nurseries which are regarded worlwide to develop the highest levels of disease pressu ....Development of molecular markers for resistance to blackleg disease (Leptosphaeria maculans) in canola. Canola (Brassica napus) is a valuable oil seed crop grown in many parts of the world and contributes annually $A450 million to the Australian economy. The overall aim of this project is to develop molecular markers for blackleg resistance using Australian germplasm along with evaluation in Australian disease nurseries which are regarded worlwide to develop the highest levels of disease pressure. Once molecular marker systems are developed and evaluated, they will be applied to facilitate the selection of Nugrain's (Industry Partner) canola breeding programs. Any molecular markers and QTL developed for Australian cultivars would find commercial application in breeding programmes.Read moreRead less
Social Glue? The contribution of sport and active recreation to community wellbeing. Australian federal, state and local governments allocate more than $4,094 million per year to the provision of sport and recreation services, facilities and programs which service more than 5 million regular participants. This funding is, in part, based on the premise that involvement in sport and recreation develops community wellbeing through the facilitation of social inclusion and connectedness. This researc ....Social Glue? The contribution of sport and active recreation to community wellbeing. Australian federal, state and local governments allocate more than $4,094 million per year to the provision of sport and recreation services, facilities and programs which service more than 5 million regular participants. This funding is, in part, based on the premise that involvement in sport and recreation develops community wellbeing through the facilitation of social inclusion and connectedness. This research will contribute to the development of policies and practices that will enhance the capability of sport and active recreation organisations to contribute to community wellbeing.Read moreRead less
Bayesian methodology for analysis of genome data with focus on the livestock industry. The aim is to develop statistical methods for the design and analysis of genome data with focus on the special needs of the livestock industry. This will significantly contribute to profitability, quality, genetic improvement and genetic knowledge in a key national industry, improve Australia's international and national profile in the key research area of bioinformatics, and encourage optimisation of current ....Bayesian methodology for analysis of genome data with focus on the livestock industry. The aim is to develop statistical methods for the design and analysis of genome data with focus on the special needs of the livestock industry. This will significantly contribute to profitability, quality, genetic improvement and genetic knowledge in a key national industry, improve Australia's international and national profile in the key research area of bioinformatics, and encourage optimisation of current information. Outcomes include a toolkit of applicable statistical methods, statistically valid algorithms, marketable methods for gene discovery, technology transfer, training and publications.Read moreRead less
Bridging the gap on locational disadvantage: Impact of community-identified interventions on social capital, psychosocial and socioeconomic outcomes. Interventions to combat locational disadvantage are vital given the pervasiveness and long-term consequences for youth and communities. This research will offer important educational and socio-economic benefits by enriching the psychosocial adjustment and life potential of young Australians and the capacity of schools in locationally disadvantaged ....Bridging the gap on locational disadvantage: Impact of community-identified interventions on social capital, psychosocial and socioeconomic outcomes. Interventions to combat locational disadvantage are vital given the pervasiveness and long-term consequences for youth and communities. This research will offer important educational and socio-economic benefits by enriching the psychosocial adjustment and life potential of young Australians and the capacity of schools in locationally disadvantaged communities. Effective research and community-identified social capital and psychosocial interventions will enhance pro-social behaviours, health, psychosocial adjustment, and school and community engagement. This will build capacity at community, school, and individual levelsand contribute to national socioeconomic wellbeing.Read moreRead less
Survival of Australia's Family Farms: Capital Raising and Credit Access. Family-run farms are an integral part of rural Australia. Given the evolving global financial crisis and the expanding complexity of managing a family farm in Australia due to increasing competition from large incorporated holdings and overseas producers, a persisting drought, rising climate variability, and constraining carbon markets, one critical issue for the sustainability of family farms is their ability to access an ....Survival of Australia's Family Farms: Capital Raising and Credit Access. Family-run farms are an integral part of rural Australia. Given the evolving global financial crisis and the expanding complexity of managing a family farm in Australia due to increasing competition from large incorporated holdings and overseas producers, a persisting drought, rising climate variability, and constraining carbon markets, one critical issue for the sustainability of family farms is their ability to access and manage successfully competitive sources of credit. This study examines the extent to which family farms are currently at a disadvantage, and what policies could be implemented to ensure their sustainability into the future via access to competitive lines of credit and appropriate financial management practices.Read moreRead less
Brassica genome organisation and evolution: unlocking the potential of using genome-specific repetitive elements for crop improvement. Introgression of chromosome segments from related Brassica species provides an opportunity to develop locally adapted varieties with improved agronomic and quality traits. There is a need to understand Brassica genome organisation and how this information can be used for enhancing the efficiency of cultivar development. Dispersed and tandem repetitive DNA sequen ....Brassica genome organisation and evolution: unlocking the potential of using genome-specific repetitive elements for crop improvement. Introgression of chromosome segments from related Brassica species provides an opportunity to develop locally adapted varieties with improved agronomic and quality traits. There is a need to understand Brassica genome organisation and how this information can be used for enhancing the efficiency of cultivar development. Dispersed and tandem repetitive DNA sequences provide valuable information on the organisation and evolution of plant chromosomes. Methods for monitoring chromosome segment transfer across Brassica species will be developed based on detecting and quantifying genome-specific repetitive DNA sequences. Australian Brassica improvement programs could benefit from this research by adopting methods to detect chromosome segment transfer during interspecific hybridisation.Read moreRead less
Identification of Traits and Function by Genomic Matching. Differences between individuals are largely inherited and therefore encoded within the DNA. The challenge is to develop practical means of detecting these differences irrespective of whether they are observable as a phenotype.
Here we focus on livestock. For example, most Australian cattle are horned rather than polled. The inheritance is relatively simple but there is still no DNA test to detect the recessive horning gene.
T ....Identification of Traits and Function by Genomic Matching. Differences between individuals are largely inherited and therefore encoded within the DNA. The challenge is to develop practical means of detecting these differences irrespective of whether they are observable as a phenotype.
Here we focus on livestock. For example, most Australian cattle are horned rather than polled. The inheritance is relatively simple but there is still no DNA test to detect the recessive horning gene.
The genomic matching technique is an in-house patented procedure for identifying such DNA differences. If successful, our test will assist industry to eliminate horning and thereby painful dehorning whilst reducing damage to workers and product.
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Exploiting the Arabidopsis genome sequence as a molecular 'toolbox' for Brassica improvement. Australia's position as a major exporter of canola (Brassica napus) is under threat from genetic improvements in yield and quality being made by our international competitors. We will identify genes from Arabidopsis (the 'tool-box') that will be used to increase the speed of selection of new canola varieties with improved oleic acid content, disease resistance, and agronomic traits such as early flower ....Exploiting the Arabidopsis genome sequence as a molecular 'toolbox' for Brassica improvement. Australia's position as a major exporter of canola (Brassica napus) is under threat from genetic improvements in yield and quality being made by our international competitors. We will identify genes from Arabidopsis (the 'tool-box') that will be used to increase the speed of selection of new canola varieties with improved oleic acid content, disease resistance, and agronomic traits such as early flowering and cold tolerance. Genome similarity between Arabidopsis and canola will be exploited to map specific genes from Arabidopsis directly into canola. Based on this knowledge, we will develop gene-specific molecular markers for rapid selection of Australian-adapted canola varieties.Read moreRead less