Multimodel Phenotyping To Predict Oral Appliance Treatment Outcome In Obstructive Sleep Apnoea
Funder
National Health and Medical Research Council
Funding Amount
$525,777.00
Summary
Obstructive sleep apnoea is a common sleep-related breathing disorder. Oral appliances worn during sleep to gently hold the lower jaw in a forward position are a novel treatment modality often appealing to patients. Currently use is limited as there is no means to determine if patients will be treated successfully. There is a need for simple, clinical methods to predict which patients are best suited to this new treatment approach and this project will address this by developing such a method.
In Australia, over 2000 families suffer the tragedy of stillbirth each year. By building on our achievements of the first Stillbirth CRE rapidly translating new research into maternity care, we will reduce stillbirth rates by 20%, and reduce inequities in stillbirth rates by Australia by 2025. We also anticipate a reduction in adverse neonatal outcomes. When stillbirth or neonatal death does occur, our research aims to ensure that all women and families receive optimal care.
Staying Connected: Personalising Stroke Recovery And Rehabilitation Through New Technologies For People With Stroke Living At Home.
Funder
National Health and Medical Research Council
Funding Amount
$1,730,999.00
Summary
One in 4 people experience a stroke. On return home the person with stroke is challenged to sense, move, think, and engage in valued activities with an altered brain and body. Yet the current approach to ongoing recovery is limited. We propose to: monitor for markers of recovery using personalised sensors and artificial intelligence; deliver bursts of therapy at point of need, at home; and provide feedback through new technologies and a central hub...to stay connected, and to recover at home.
Prediction Of Fracture By Clinico-genetic Profiling
Funder
National Health and Medical Research Council
Funding Amount
$2,339,215.00
Summary
The loss of bone with advancing age is the main cause of osteoporosis and bone fracture. Bone loss is highly variable between individuals, and we are not sure why. I want to find out factors that contribute to bone loss, and then use this knowledge to identify individuals at high risk of excessive bone loss for early prevention. My goal over the next 5 years is to create a new clinico-genetic model for assessing the rate of bone loss, and predicting the risk of fracture for an individual.
The Landscape Of Cancer Genes And Associations With Prognosis In Breast Cancer Diagnosed In Premenopausal Women
Funder
National Health and Medical Research Council
Funding Amount
$700,512.00
Summary
Using state of the art technology, the purpose of this project is understand the implications of known cancer mutations in breast cancer diagnosed in premenopausal ER-positive breast cancer. Mutations are abnormalities in the DNA of genes that can provide a signal for uncontrolled growth, a hallmark of cancer. The unique aspect of this project is use of tissue samples from patients who were diagnosed with breast cancer at a young age. This information will help us develop new treatments.
A Risk Stratification Tool For The Prevention Of Avoidable Perinatal Mortality And Morbidity
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
Stillbirth is more common in Australia than in some high-income countries. Babies born early may experience lung or other problems. Many current stillbirths and preterm birth can be prevented. Using a cohort of >4.5 million births from WA, NSW, SA and NT (N >4.5 million), this project will develop a strategy to predict the risk of stillbirth, preterm birth, and low birth weight. Better identification of risk in pregnancy will improve antenatal care to reduce stillbirth and neonatal morbidi ....Stillbirth is more common in Australia than in some high-income countries. Babies born early may experience lung or other problems. Many current stillbirths and preterm birth can be prevented. Using a cohort of >4.5 million births from WA, NSW, SA and NT (N >4.5 million), this project will develop a strategy to predict the risk of stillbirth, preterm birth, and low birth weight. Better identification of risk in pregnancy will improve antenatal care to reduce stillbirth and neonatal morbidity.Read moreRead less
Advancement Of A Personalised Approach To Minimising Infective Complications In Cancer Care
Funder
National Health and Medical Research Council
Funding Amount
$265,138.00
Summary
Managing infections in patients with cancer have become more difficult and unpredictable because of new generation cancer therapies. Measuring the response of the immune system (immune profiling) will allow us to predict which patients will develop infection so that action such as vaccination can be taken to reduce their risk. This program will refine immune profiling to personalise infection care for cancer patients and to introduce it into hospital practice.
PRE-EMPT: Prediction Of Early Mental Disorder And Preventive Treatment - Centre Of Research Excellence
Funder
National Health and Medical Research Council
Funding Amount
$2,500,000.00
Summary
Mental health clinicians currently do not have the means to predict which young people with emerging symptoms are most at risk of progressing to serious mental illness. This CRE will help us better understand how mental illnesses develop, identify the risk and protective factors, and introduce tools for use in clinical practice to better predict onset of serious mental illness. This will help with providing and further developing early treatments to delay or prevent the onset of mental illness.